Cardiovascular Actions of Taurine, γ-Aminobutyric Acid (GABA), and γ-Amino- ß-hydroxybutyric Acid (GABOB) after Chemical Denervation

Ito, Ryuta; Uchiyama, Toshimitsu; Yoda, Shuko; Homma, Noriaki; Furukawa, Katsuo

doi:10.1007/978-94-009-8093-8_23

Cited by 3 publications

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“…Supporting this possibility are reports suggesting that in vitro addition of taurine significantly attenuated the Ca caused an immediate decrease in blood pressure -an effect that disappeared after chemical denervation with guanethidine or 6-hydroxydopamine. 25 These observations were interpreted in terms of an effect of taurine on catecholamine release. Furthermore, while in vitro addition of taurine suppressed the stress-induced release of NE from rat superior cervical ganglia, neither leucine nor methionine had any preventive effect on the NE or acetylcholine release.…”

Section: Figure 2 Effects Of Taurine Supplementation On Cardiac and mentioning

confidence: 98%

Role of sympathetic nervous system in hypotensive action of taurine in DOCA-salt rats.

Sato¹,

Ando²,

Fujita³

1987

Hypertension

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SUMMARY We tested the hypothesis that the antihypertensive effects of dietary taurine supplementation in deoxycorticosterone acetate (DOCA)-salt rats may be attributed to the suppression of sympathetic nervous system activity. In uninephrectomized rats treated with DOCA while receiving 1 % NaCl solution for 2 weeks, systolic blood pressure was significantly increased as compared with that in control rats treated with vehicle suspension and tap water. Sympathetic nervous system activity was assessed by tissue norepinephrine turnover, which was determined from the rate of decline of tissue norepinephrine concentration after the administration of a-methyl-p-tyrosine, a potent inhibitor of the rate-limiting step of catecholamine synthesis. Cardiac and splenic norepinephrine turnover during either normal conditions or cold exposure (4°C, 8 hours) were markedly increased in DOCAsalt rats as compared with controi rats. Also, DOCA-salt rats had increased depressor response to hexamethoniom bromide, a ganglion blocker. In contrast, supplementation of 1 % taurine in DOCAsalt rats attenuated the development of the hypertension associated with the normalization of both the Increased depressor response to ganglionic blockade and the accelerated cardiac and splenic norepinephrine turnover during either normal conditions or cold exposure. Taurine supplementation in control rats, however, had no effect on blood pressure or norepinephrine turnover during cold exposure. These results suggest that taurine supplementation suppresses sympathetic overactivity in DOCA-salt rats, thus leading to inhibition of the development of hypertension. (Hypertension 9: 81-87, 1987) KEY WORDS • taurine • deoxycorticosterone acetate-salt hypertension • norepinephrine turnover • cold exposure • sympathetic nervous system T AURINE (2-aminoethanesulfonic acid) is abundantly present in the brain, heart, and muscle of mammals, 1 but its possible function in normal or disease states has not been clearly defined. Taurine supplementation in the stroke-prone strain of spontaneously hypertensive rats reportedly attenuates die development of the hypertension 2 ; however, the mechanism for the antihypertensive action of taurine is unknown.Our previous study 3 demonstrated that dietary taurine supplementation in deoxycorticosterone acetate (DOCA)-salt rats could not only attenuate the development of the hypertension but also reduce blood pres- Received January 29, 1986, accepted July 22, 1986 sure when taurine was given after DOCA-salt hypertension had been established. There is a good deal of evidence that increased sympathetic nervous system (SNS) activity is involved in the development of DOCA-salt hypertension in rats. 4 " 7 The norepinephrine (NE) turnover rate, an indirect in vivo means of quantifying the activity of SNS, 8 is increased in most peripheral sympathetically innervated organs of DOCA-salt rats, such as the heart, spleen, and intestine.4 -3 Moreover, it has been reported that in vitro addition of taurine significantly attenuates the Ca 2+ -...

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Section: Figure 2 Effects Of Taurine Supplementation On Cardiac and mentioning

confidence: 98%