Cardiovascular Activity of the Chemical Constituents of Essential Oils

Andrade, Tadeu Uggere de; Brasil, Girlândia Alexandre; Endringer, Denise Coutinho; Nóbrega, Flávio Rogério da; Sousa, Damião Pergentino de

doi:10.3390/molecules22091539

Cited by 28 publications

(19 citation statements)

References 77 publications

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“…Another study showed that γ-terpinene inhibits LDL oxidation [34]. In addition, the cardiovascular activity of essential oils and their individual volatile constituents, such as α-terpineol, α-terpinene, and γ-terpinene, all have potent antioxidative capabilities resulting from the restoration of antioxidant enzyme activities [35]. Limonene, linalool, and 4-terpineol are beneficial in terms of preventing cardiovascular diseases and hypertension.…”

Section: Resultsmentioning

confidence: 99%

Lime (Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect

Lin

Chuang

Chen

et al. 2019

Foods

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Lime peels are mainly obtained from the byproducts of the juice manufacturing industry, which we obtained and used to extract essential oil (2.3%) in order to examine the antioxidant and hypolipidaemic effects. We identified 60 volatile compounds of lime essential oil (LEO) with GC/MS, of which the predominant constituents were limonene, γ-terpinene, and β-pinene. Lime essential oil was measured according to the DPPH assay and ABTS assay, with IC50 values of 2.36 mg/mL and 0.26 mg/mL, respectively. This study also explored the protective effects of LEO against lipid-induced hyperlipidemia in a rat model. Two groups of rats received oral LEO in doses of 0.74 g/100 g and 2.23 g/100 g with their diets. Eight weeks later, we found that the administration of LEO improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase levels in the hyperlipidemic rats (p < 0.05). Simultaneously, the LEO improved the health of the rats in terms of obesity, atherogenic index, and fatty liver.

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Section: Resultsmentioning

confidence: 99%

Lime (Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect

Lin

Chuang

Chen

et al. 2019

Foods

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“…Other benefits for treating cardiovascular disease, thus reducing the risk of atherosclerosis, include the reduction of cholesterol and triglyceride levels in plasma, in which black cumin oil achieved this reduction in rats over a period of 12 weeks, with low toxicity and no adverse effects in kidneys or liver [ 7 ]. Additionally, recent studies have demonstrated the capability of EOs to act on inflammatory and other cellular processes associated with cardiovascular diseases, by preventing the secretion of proinflammatory factors through the reduction of lipopolysaccharide (LPS) [ 30 , 31 ]. EOs may be used in both analgesics and anti-inflammatories, such as black cumin and eucalyptus oils [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Essential Oils and Other Natural Products

Blowman

Magalhães

Lemos

et al. 2018

Evidence-Based Complementary and Alternative Medicine

220

119

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Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimicrobial activity, and have long been utilized for treating various human ailments and diseases. Cancer cell prevention and cytotoxicity are exhibited through a wide range of mechanisms of action, with more recent research focusing on synergistic and antagonistic activity between specific essential oils major and minor components. Essential oils have been shown to possess cancer cell targeting activity and are able to increase the efficacy of commonly used chemotherapy drugs including paclitaxel and docetaxel, having also shown proimmune functions when administered to the cancer patient. The present review represents a state-of-the-art review of the research behind the application of EOs as anticancer agents both in vitro and in vivo. Cancer cell target specificity and the use of EOs in combination with conventional chemotherapeutic strategies are also explored.

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“…Among the most prominent and therapeutically potentially promising activities of natural monoterpenes and monoterpenoids are those on the cardiovascular system [6]. Reports on literature, here reviewed and discussed, reveal their effect on heart (rate and inotropism), systemic blood pressure (SBP), and blood vessels (direct (myogenic) and indirect (endothelium mediated)) [7][8][9][10].…”

Section: Terpenes and Terpenoidsmentioning

confidence: 99%

Effects of Terpenes and Terpenoids of Natural Occurrence in Essential Oils on Vascular Smooth Muscle and on Systemic Blood Pressure: Pharmacological Studies and Perspective of Therapeutic Use

Cardoso-Teixeira¹,

Oliveira-Abreu²,

Brito³

et al. 2021

Terpenes and Terpenoids - Recent Advances

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Terpenes are a class of chemical compounds with carbon and hydrogen atoms in their structure. They can be classified into several classes according to the quantity of isoprene units present in its structure. Terpenes can have their structure modified by the addition of various chemical radicals. When these molecules are modified by the addition of atoms other than carbon and hydrogen, they become terpenoids. Terpenes and terpenoids come from the secondary metabolism of several plants. They can be found in the leaves, fruits, stem, flowers, and roots. The concentration of terpenes and terpenoids in these organs can vary according to several factors such as the season, collection method, and time of the day. Several biological activities and physiological actions are attributed to terpenes and terpenoids. Studies in the literature demonstrate that these molecules have antioxidant, anticarcinogenic, anti-inflammatory, antinociceptive, antispasmodic, and antidiabetogenic activities. Additionally, repellent and gastroprotective activity is reported. Among the most prominent activities of monoterpenes and monoterpenoids are those on the cardiovascular system. Reports on literature reveal the potential effect of monoterpenes and monoterpenoids on systemic blood pressure. Studies show that these substances have a hypotensive and bradycardic effect. In addition, the inotropic activity, both positive and negative, of these compounds has been reported. Studies also have shown that some monoterpenes and monoterpenoids also have a vasorelaxing activity on several vascular beds. These effects are attributed, in many cases to the blocking of ion channels, such as voltage-gated calcium channels. It can also be observed that monoterpenes and monoterpenoids can have their effects modulated by the action of the vascular endothelium. In addition, it has been shown that the molecular structure and the presence of chemical groups influence the potency and efficacy of these compounds on vascular beds. Here, the effect of several monoterpenes and monoterpenoids on systemic blood pressure and vascular smooth muscle will be reported.

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Cardiovascular Activity of the Chemical Constituents of Essential Oils

Cited by 28 publications

References 77 publications

Lime (Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect

Lime (Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect

Anticancer Properties of Essential Oils and Other Natural Products

Effects of Terpenes and Terpenoids of Natural Occurrence in Essential Oils on Vascular Smooth Muscle and on Systemic Blood Pressure: Pharmacological Studies and Perspective of Therapeutic Use

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