Cardiovascular and autonomic alterations in rats with Parkinsonism induced by 6-OHDA and treated with L-DOPA

Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise

“…In relation to the baseline cardiovascular parameters, there were no changes in the MAP and HR values of the 6-OHDA S groups in relation to Sham S, which corroborates with data from the literature using the same model [31]. The present study confirms previous data from the literature that swimming does not alter MAP values in rats, but induces Fig.…”

“…The model of Parkinsonism by 6-OHDA infusion in SNpc, is a classic model, which presents behavioral and motor changes characterized of PD [24,30]. In the present study, it can be observed that there was a decrease of > 50% in DA concentrations after 7 days of 6-OHDA infusion, which corroborates with other studies using the same model [5,31]. This amount of depletion has been found in animal models that attempt to mimic the early stages of PD along with the onset of motor symptoms [30,32].…”

Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6‐OHDA parkinsonism: Involvement of nNOS

“…In addition, 7 days after injury to SNpc by infusion of 6‐OHDA, there was a reduction in baseline values of MAP and HR, as well as changes in autonomic modulation of the cardiovascular parameters, with the reduction in the variance and the sympathetic modulation of the SAP and PI and increase in the parasympathetic activity in the PI. Our data are in agreement with previous studies that evaluated cardiovascular and autonomic modulation in rats induced to 6‐OHDA parkinsonism . Also, the same model, and using the same concentration of 6‐OHDA and on the same day after the injury in which we performed the cardiovascular evaluation, it was observed that locomotor deficiencies in injured animals compared to controls, corroborating for the characterization of Parkinsonism model.…”

Preclinical safety assessments of nano‐sized constructs on cardiovascular system toxicity: A case for telemetry

“…The power spectral analysis algorithms can also be used to integrate the oscillatory components of cardiovascular short-term variability, such as HR variability and BP variability in the frequency domain, into three frequency regions: very low frequency (0.01-0.20 Hz), low frequency (0.20-0.80 Hz) and high frequency (0.80-3.0 Hz) ( Japundzic-Zigon, 1998;Van De Borne et al, 1997). The low frequency/high frequency ratio of HR variability reflects the state of cardiac sympatho-vagal balance (Montano et al, 1994;Oosting et al, 1997;Silva et al, 2015), while rhythmic oscillations at various frequencies reflect cardiac sympathetic or parasympathetic reflex control on the CVS in physiological and pathophysiological conditions, as summarized in Fig. 4 (Akselrod et al, 1981;La Rovere et al, 2001;Montano et al, 1994).…”