Cardiovascular and Immune Responses to Acute Psychological Stress in Young and Old Women

Benschop, Robert J.; Geenen, Rinie; Mills, Paul J.; Naliboff, Bruce D.; Kiecolt‐Glaser, Janice K.; Herbert, Tracy B.; Pompe, Gieta Van Der; Miller, Gregory E.; Matthews, Karen A.; Godaert, G. L. R.; Gilmore, Stephanie L.; Glaser, Ronald; Heijnen, Cobi J.; Dopp, Joel M.; Bijlsma, J. W. J.; Solomon, George F.; Cacioppo, John T.

doi:10.1097/00006842-199805000-00015

Cited by 85 publications

(45 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with coronary heart disease, mental-stress-induced myocardial ischaemia is more frequent in people who show exaggerated blood pressure and heart rate responses to mental stress tests [45]. Individual differences in cardiovascular stress responsivity are also correlated with the magnitude of acute increases in the number of circulating natural killer cells [46].…”

Section: Discussionmentioning

confidence: 99%

Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

et al. 2001

View full text Add to dashboard Cite

The influence of acute mental stress on cardiovascular responses and concentrations of inflammatory cytokines up to 2 h later was assessed in 12 subjects exposed to stress and in eight control subjects. Beat-by-beat recordings of finger blood pressure and heart rate were made at rest and during two behavioural tasks (colour-word interference and mirror tracing). Blood was drawn after adaptation and at 45 min and 2 h after the tasks, and assayed for interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), interleukin-1 receptor antagonist (IL-1Ra), C-reactive protein (CRP) and haematocrit. Saliva was sampled periodically and assayed for free cortisol. The tasks were rated as stressful by the participants. The stress group showed significant increases in systolic and diastolic blood pressure (mean rises of 16.4p12.3 and 12.6p6.9 mmHg respectively) and heart rate (5.39p5.3 beats/min) ; these values returned to baseline during the recovery period. The IL-6 concentration was increased by 56 % at 2 h after the tasks (P 0.05), while IL1Ra was increased by 12.3 % (P 0.01). No changes in cardiovascular variables or cytokine concentrations were observed in the control subjects, and haematocrit did not change. The magnitude of blood pressure responses during tasks was correlated positively with the IL-6 concentration after 45 min (r l 0.70, P 0.05), and with the IL-1Ra concentration after 2 h (r l 0.63, P 0.05). Increases in TNF-α after 2 h were correlated with heart rate responses to tasks (r l 0.66, P 0.05). Associations between IL-6 and IL-1Ra concentrations were also recorded. This study indicates that inflammatory cytokines respond to acute mental stress in humans with delayed increases, and suggest that individual differences in cytokine responses are associated with sympathetic reactivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

et al. 2001

View full text Add to dashboard Cite

show abstract

“…The GSST has been found to elicit significant changes in heart rate and in the HPA-system (Benschop et al, 1998;Van der Pompe et al, 1998). During the GSST, heart rate was recorded continuously.…”

Section: The Groningen Social Stress Test (Gsst)mentioning

confidence: 99%

Adolescents’ cortisol responses to awakening and social stress; Effects of gender, menstrual phase and oral contraceptives. The TRAILS study

Bouma

Riese

Ormel

et al. 2009

Psychoneuroendocrinology

212

180

View full text Add to dashboard Cite

. (2009). Adolescents' cortisol responses to awakening and social stress; Effects of gender, menstrual phase and oral contraceptives. The TRAILS study. Psychoneuroendocrinology, 34(6), 884-893. DOI: 10.1016884-893. DOI: 10. /j.psyneuen.2009 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Summary Studies on the influence of sex hormones on cortisol responses to awakening and stress have mainly been conducted in adults, while reports on adolescents are scarce. We studied the effects of gender, menstrual cycle phase and oral contraceptive (OC) use on cortisol responses in a large sample of adolescents. Data come from TRAILS (TRacking Adolescents' Individual Lives Survey), a prospective population study of Dutch adolescents. This study uses data of 644 adolescents (age 15-17 years, 54.7% boys) who participated in a laboratory session including a performance-related social stress task (public speaking and mental arithmetic). Free cortisol levels were assessed by multiple saliva samples, both after awakening and during the laboratory session. No significant effects of gender and menstrual phase on cortisol responses to awakening were found, while girls using OC displayed a slightly blunted response (F(1, 244) = 5.30, p = .02). Cortisol responses to social stress were different for boys and free-cycling girls (F(3, 494) = 9.73, p < .001), and OC users and free-cycling girls (F(3, 279) = 15.12, p < .001). Unexpectedly, OC users showed no response at all but displayed linearly decreasing levels F(1, 279) = 19.03, p < .001) of cortisol during the social stress test. We found no effect of menstrual cycle phase on cortisol responses to social stress (F(3, 157) = 0.58, p = .55). The absence of a gender difference in the adolescents' cortisol awakening response found in this study is consistent with

show abstract

“…Previous studies examining heart rate in stressful situations find heart rates that range from 75 to 90 in laboratory situations. 41 Such situations include mental arithmetic at 75 bpm 42 ; negative feedback during a laboratory task at 87 bpm 43 ; videotaped speech and problem solving at 79 bpm 44 and 87 bpm 45 ; and couple discussions of marital conflict at 90 bpm. 46 In a highstress study examining first-time tandem parachute jumps, bpm reached 140.…”

Section: Physiological Stress Responsementioning

confidence: 99%

Previous Trauma Exposure and PTSD Symptoms as Predictors of Subjective and Biological Response to Stress

et al. 2007

View full text Add to dashboard Cite

Objective:The immediate and long-term effects of traumatic exposure and subsequent posttraumatic stress reactions in people in high-risk occupations are well-documented. What is less evident is the impact of this traumatic exposure and subsequent traumatic stress symptoms on workers' response to acute stress situations. This study aimed to examine the association between prior traumatic exposure related to policing, current posttraumatic stress symptoms and biological markers of stress, and subjective appraisal of stress before, during, and after exposure to acutely stressful stimuli. Method:A stressful policing situation was created through the use of a video simulator room. Participants' responses to the simulated emergency were evaluated by monitoring heart rate, collecting salivatory samples for cortisol analysis, and repeated administration of a subjective measure of anxiety.Results: Biological indicators of stress, as measured by cortisol level and heart rate, were not associated with previous trauma exposure or trauma symptoms; however, biological response was associated with subjective anxiety. Vulnerability to psychological stress responses during an acute stress situation was also associated with lower levels of social support, previous traumatic exposures, and preexisting symptoms of traumatic stress. The importance of these factors became more pronounced as time progressed after the event. Conclusion:Previous trauma exposure did not put individuals at increased risk of biological distress during an acute stress situation. However, previous trauma and reduced social supports were associated with continuing psychological distress, confirming previous research and raising concerns about the cumulative negative effects of traumatic exposure on psychological health in emergency responders.(Can J Psychiatry 2007;52: [675][676][677][678][679][680][681][682][683] Information on funding and support and author affiliations appears at the end of the article. Clinical Implications· Emergency responders enter training with previous traumatic exposures, potentially increasing vulnerability to stress and distress throughout their career. · Prior trauma exposure did not increase psychological distress during an acute situation, suggesting individuals can manage crisis situations. · Prior trauma exposure was associated with higher psychological distress in follow-up, suggesting possible risk and potential need for intervention. Limitations· This research was conducted on police recruits and may not be generalizable to other populations.· The acute stress situation was a simulated, not real-life, exposure. · Physiological and psychological distress was only measured within a short time frame, and thus long-term follow-up will be useful.

show abstract

Cardiovascular and Immune Responses to Acute Psychological Stress in Young and Old Women

Cited by 85 publications

References 30 publications

Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels

Adolescents’ cortisol responses to awakening and social stress; Effects of gender, menstrual phase and oral contraceptives. The TRAILS study

Previous Trauma Exposure and PTSD Symptoms as Predictors of Subjective and Biological Response to Stress

Contact Info

Product

Resources

About