Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill

Kumarathasan, Premkumari; Vincent, Renaud; Blais, Erica; Bielecki, A; Guénette, Josée; Filiatreault, Alain; Brion, Orly; Cakmak, Sabit; Thomson, Errol M.; Shutt, Robin; Kauri, Lisa Marie; Mahmud, Mamun; Liu, Ling; Dales, Robert

doi:10.1186/s12989-018-0270-4

Cited by 32 publications

(17 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 shows the selection process of literature. We identified 44 studies from citations screened ( Chen et al., 2018 ; Chuang et al., 2007 ; Cole et al., 2018 ; Croft et al., 2017 ; Dadvand et al., 2014 ; Delfino et al., 2010 ; Deng et al., 2020 ; Dubowsky et al., 2006 ; Emmerechts et al., 2012 ; Forbes et al., 2009 ; Green et al., 2016 ; Habre et al., 2018 ; Hajat et al., 2015 ; Hassanvand et al., 2017 ; Hildebrandt et al., 2009 ; Hoffmann et al., 2009 ; Huttunen et al., 2012 ; Kumarathasan et al., 2018 ; Lanki et al., 2015 ; Lee et al., 2018 ; Liao et al., 2005 ; Mirowsky et al., 2015 ; Pekkanen et al., 2000 ; Pope et al., 2016 ; Puett et al., 2019 ; Rich et al., 2012 ; Ruckerl et al., 2007 ; Rückerl et al., 2014 ; Rudez et al., 2009 ; Schneider et al., 2010 ; Schwartz, 2001 ; Seaton et al., 1999 ; Steinvil et al., 2008 ; Strak et al., 2013 ; Su et al., 2017 ; Sullivan et al., 2007 ; Tsai et al., 2012 ; Viehmann et al., 2015 ; Wang et al., 2018 ; Wu et al., 2012 ; Zeka et al., 2006 ; Zhang et al., 2016 , 2020 ; Zuurbier et al., 2011 ). Supplemental Table S3 provides the characteristics of included studies.…”

Section: Resultsunclassified

See 1 more Smart Citation

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

Tang

Cheng

et al. 2020

Environmental Pollution

View full text Add to dashboard Cite

Inflammation and the coagulation cascade are considered to be the potential mechanisms of ambient particulate matter (PM) exposure-induced adverse cardiovascular events. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and fibrinogen are arguably the four most commonly assayed markers to reflect the relationships of PM with inflammation and blood coagulation. This review summarized and quantitatively analyzed the existing studies reporting short- and long-term associations of PM 2.5 (PM with an aerodynamic diameter ≤2.5 μm)/PM 10 (PM with an aerodynamic diameter≤10 μm) with important inflammation and blood coagulation markers (TNF-α, IL-6, IL-8, fibrinogen). We reviewed relevant studies published up to July 2020, using three English databases (PubMed, Web of Science, Embase) and two Chinese databases (Wang-Fang, China National Knowledge Infrastructure). The OHAT tool, with some modification, was applied to evaluate risk of bias. Meta-analyses were conducted with random-effects models for calculating the pooled estimate of markers. To assess the potential effect modifiers and the source of heterogeneity, we conducted subgroup analyses and meta-regression analyses where appropriate. The assessment and correction of publication bias were based on Begg’s and Egger’s test and “trim-and-fill” analysis. We identified 44 eligible studies. For short-term PM exposure, the percent change of a 10 μg/m 3 PM 2.5 increase on TNF-α and fibrinogen was 3.51% (95% confidence interval (CI): 1.21%, 5.81%) and 0.54% (95% confidence interval (CI): 0.21%, 0.86%) respectively. We also found a significant short-term association between PM 10 and fibrinogen (percent change = 0.17%, 95% CI: 0.04%, 0.29%). Overall analysis showed that long-term associations of fibrinogen with PM 2.5 and PM 10 were not significant. Subgroup analysis showed that long-term associations of fibrinogen with PM 2.5 and PM 10 were significant only found in studies conducted in Asia. Our findings support significant short-term associations of PM with TNF-α and fibrinogen. Future epidemiological studies should address the role long-term PM exposure plays in inflammation and blood coagulation markers level change.

show abstract

Section: Resultsunclassified

“…Among healthy humans, Kumarathasan et al. reported insignificant changes of TNF-α, IL-6, and IL-8 with short-term PM 2.5 exposure ( Kumarathasan et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

Tang

Cheng

et al. 2020

Environmental Pollution

View full text Add to dashboard Cite

show abstract

“…A study on healthy people who spent 5 days near a steel plant showed that both of the systolic and diastolic blood pressures were higher in those volunteers who did not use mask in this area [17].…”

Section: Environmental Emissionsmentioning

confidence: 99%

Effects of Environmental Emissions on the Respiratory System: Secrets and Consequences

Hajirasouliha¹,

Zabiegaj²

2021

Environmental Emissions

View full text Add to dashboard Cite

Human health has been affected adversely by air pollution as a serious environmental challenge. Ambient (outdoor) air pollution mainly resulted from human activities (e.g., fuel combustion, heat generation, industrial facilities) causes 4.2 million deaths every year. Moreover, each year, 3.8 million people die from indoor air pollution which means household exposure to smoke from fuels and dirty cook stoves. They are the risks of stroke, heart attack, lung disease, or cancer that resulted from air pollution which assaults our brain, heart, and lungs using its invisible weapons named particulate matter (PM). These inhalable particles are of a nanoscale or microscale size. Upon inhalation, the air with its components enters the human body through the respiratory system. The lungs are the responsible organs for gas exchange with blood. Inhaled particles, such as silica, organic compounds, and metallic dusts, have toxic effects on our pulmonary system. For example, the accumulation of nanoparticles in the kidneys, liver, spleen, and central nervous system through the penetration of the epithelial barriers in the lungs has been observed. The purpose of this chapter is to describe the toxic effects of air particles on the different organs in the human body and to introduce some of the adverse effects of air pollution on human health.

show abstract

“…Finally, an important area of investigation in environmental epidemiology has been the identification of specific components in PM 2:5 that may lead to adverse health outcomes. PM 2:5 constituents differ in toxicity (Bell et al 2014;Franklin et al 2008), and some prior studies have identified a heightened effect of steelrelated airborne metals on inflammation (Ghio and Devlin 2001;Kumarathasan et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults

Tripathy

Marsland

Kinnee

et al. 2021

Environ Health Perspect

View full text Add to dashboard Cite

BACKGROUND: Chronic exposure to air pollution may prime the immune system to be reactive, increasing inflammatory responses to immune stimulation and providing a pathway to increased risk for inflammatory diseases, including asthma and cardiovascular disease. Although long-term exposure to ambient air pollution has been associated with increased circulating markers of inflammation, it is unknown whether it also relates to the magnitude of inflammatory response. OBJECTIVES: The aim of this study was to examine associations between chronic ambient pollution exposures and circulating and stimulated levels of inflammatory mediators in a cohort of healthy adults. METHODS: Circulating interleukin (IL)-6, C-reactive protein (CRP) (n = 392), and lipopolysaccharide stimulated production of IL-1b, IL-6, and tumor necrosis factor ðTNFÞ-a (n = 379) were measured in the Adult Health and Behavior II cohort. Fine particulate matter [particulate matter with aerodynamic diameter less than or equal to 2.5 μm (PM 2:5 )] and constituents [black carbon (BC), and lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe)] were estimated for each residential address using hybrid dispersion land use regression models. Associations between pollutant exposures and inflammatory measures were examined using linear regression; models were adjusted for age, sex, race, education, smoking, body mass index, and month of blood draw. RESULTS: There were no significant correlations between circulating and stimulated measures of inflammation. Significant positive associations were found between exposure to PM 2:5 and BC with stimulated production of IL-6, IL-1b, and TNF-a. Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1b and TNF-a. No pollutants were associated with circulating IL-6 or CRP levels. DISCUSSION: Exposure to PM 2:5 , BC, Pb, Mn, Fe, and Zn was associated with increased production of inflammatory mediators by stimulated immune cells. In contrast, pollutant exposure was not related to circulating markers of inflammation. These results suggest that chronic exposure to some pollutants may prime immune cells to mount larger inflammatory responses, possibly contributing to increased risk for inflammatory disease.

show abstract

Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill

Cited by 32 publications

References 73 publications

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

Effects of Environmental Emissions on the Respiratory System: Secrets and Consequences

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults

Contact Info

Product

Resources

About