Cardiovascular and metabolic effects associated with nifedipine and ritodrine tocolysis

Management of preterm labor: atosiban or nifedipine?

“…These trials report only minor or no reductions in diastolic or systolic blood pressure in normotensive pregnant women during the tocolysis extended-release regimen. Two studies focusing on the short term effects of nifedipine in normotensive pregnant women found hypotension accompanied with tachycardia 45 minutes after nifedipine administration 41,49. Randomized studies of tocolytic drugs have generally been restricted to well-defined (low risk) populations, excluding multiple gestations, preterm premature rupture of membranes (PPROM), vaginal blood loss, maternal diabetes, or a history of cardiovascular disease.…”

Comparison of Salbutamol and Nifedipine as a Tocolytic Agent in the Treatment of Preterm Labour

“…14 None of our patient had pulmonary edema but on review of literature one case of pulmonary edema among 582 women was reported treated with betaagonist by Ferguson JE et al 17 This is possibly because of small sample size. Regarding neonatal outcome in terms of stay was similar in nursery in both groups.…”

Short communications

“…Intra-uterine pharmacologic cardioversion has been advised in the preterm fetus [5][6][7]9]. In a review of the literature we found no reports on the management of atrial flutter in the term fetus.…”

“…Nifedipine, a dihydropiridine calcium antagonist, is effective as smooth muscle relaxant [4,5,11,14] and is known for its low toxicity. It has been suggested that the use of nifedipine in the treatment of preterm labour is associated with less maternal and fetal side effects than with the use of intravenous ß 2 -mimetics [2,5,6].…”