Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats

Overton, J. M.; Williams, Todd D.; Chambers, James B.; Rashotte, Michael E.

doi:10.1152/ajpregu.2001.280.4.r1007

Cited by 64 publications

(68 citation statements)

References 62 publications

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“…These results agree with earlier reports using telemetric monitoring in Zucker-fatty rats [2,3,19]. This tendency was also observed in WBN/Kob diabetic rats and streptozotocin-diabetic rats [11,13].…”

Section: Discussionsupporting

confidence: 93%

Characteristics of Autonomic Nervous Function in Zucker-Fatty Rats: Investigation by Power Spectral Analysis of Heart Rate Variability.

2004

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Abstract:We investigated the characteristics of autonomic nervous function in Zucker-fatty and Zucker-lean rats. For this purpose, a long-term electrocardiogram (ECG) was recorded from conscious and unrestrained rats using a telemetry system, and the autonomic nervous function was investigated by power spectral analysis of heart rate variability (HRV). Although heart rate (HR) in Zucker-fatty rats was lower than that in Zucker-lean rats throughout 24 h, apparent diurnal variation in HR was observed in both strains and HR during the dark period was significantly higher than that in light period. Diurnal variation in locomotor activity (LA) in Zucker-fatty rats was also observed, but LA was lower than that in Zucker lean rats, especially during the dark period. There were no significant differences, however, in high-frequency (HF) power, low-frequency (LF) power, and the LF/HF ratio between Zucker-fatty and Zucker-lean rats. The circadian rhythm of these parameters was mostly preserved in both strains of rats. Moreover, the effect of autonomic blockades on HRV was nearly the same in Zucker-fatty and Zucker-lean rats. These results suggest that the autonomic nervous function of insulin-resistant Zucker-fatty rats remain normal, from the aspect of power spectral analysis of HRV.

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Section: Discussionsupporting

confidence: 93%

Characteristics of Autonomic Nervous Function in Zucker-Fatty Rats: Investigation by Power Spectral Analysis of Heart Rate Variability.

2004

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“…Studies on the effects of 48-72-h fasting on physical activity in rodents have given conflicting results, indicating increased (Overton et al, 2001), decreased (Williams et al, 2000) or no change in physical activity (Nagashima et al, 2003). During long-term chronic food restriction in rodents however, an increase in physical activity is generally observed.…”

Section: Effects Of Energy Deficit On Physical Activity In Rodentsmentioning

confidence: 99%

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

Sainsbury

Zhang

2010

Molecular and Cellular Endocrinology

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Acute or long-term energy deficit in lean or obese rodents or humans stimulates food intake or appetite and reduces metabolic rate or energy expenditure. These changes contribute to weight regain in post-obese animals and humans. Some studies show that the reduction in metabolic rate with energy deficit in overweight people is transient. Energy restriction has been shown in some but not all studies to reduce physical activity, and this may represent an additional energy-conserving adaptation. Energy restriction up-regulates expression of the orexigenic neuropeptide Y, agouti related peptide and opioids and down-regulates that of the anorexigenic alpha-melanocyte stimulating hormone or its precursor pro-opioomelanocortin and the co-expressed cocaine and amphetamine-regulated transcript in the arcuate nucleus of the hypothalamus. Recapitulating these hypothalamic changes in sated animals mimics the effects of energy deficit, namely increased food intake, reduced physical activity and reduced metabolic rate, suggesting that these energy-conserving adaptations are at least partially mediated by the hypothalamus.

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“…Room temperatures below the thermoneutral range (29°C to 30°C in rodents) tend to increase metabolic rate, food intake, and BP. 84,85 In C57BL/6J mice, increasing room temperature from 23°C (the usual temperature at which most animal facilities are maintained) to 30°C for several days reduced light-phase mean arterial pressure and heart rate, measured by telemetry, by 14 mm Hg and 184 bpm, respectively. 84 Similar results have also been found in several strains of rats.…”

Section: Environmental Influences On Bpmentioning

confidence: 99%

Recommendations for Blood Pressure Measurement in Humans and Experimental Animals

Kurtz¹,

Griffin²,

Bidani³

et al. 2005

Hypertension

256

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Abstract-In experimental animals, as in humans, techniques for measuring blood pressure (BP) have improved considerably over the past decade. In this document, we present recommendations for measuring BP in experimental animals with the goal of helping investigators select optimal methods for BP monitoring in the research laboratory. The advantages and disadvantages of various BP measurement methods are discussed and specific recommendations are provided for selecting the optimal technique depending on the study objective. Although indirect techniques that permit only sporadic measurements of BP may be suitable for some purposes, methods for directly measuring BP are generally preferred because of their ability to monitor the highly dynamic nature of BP in a comprehensive fashion. Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored.

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Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats

Cited by 64 publications

References 62 publications

Characteristics of Autonomic Nervous Function in Zucker-Fatty Rats: Investigation by Power Spectral Analysis of Heart Rate Variability.

Characteristics of Autonomic Nervous Function in Zucker-Fatty Rats: Investigation by Power Spectral Analysis of Heart Rate Variability.

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

Recommendations for Blood Pressure Measurement in Humans and Experimental Animals

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