Cardiovascular and neurohumoral responses following burn injury

Crum, RL; Dominic, William; Hansbrough, John F.; Brown,

doi:10.1016/s0196-0644(89)80731-0

Cited by 8 publications

(16 citation statements)

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“…With the exception of one study (Crum et al, 1990), the mean plasma concentration of AVP in admission blood samples was higher in our burn-injured children than values reported for adults (Shirani et al, 1983;Morgan et al, 1980;Crum et al, 338 1988), although the mean burn size of the patients in this study was lower (20 . 5%).…”

Section: Discussioncontrasting

confidence: 66%

The systemic stress response to thermal injury in children

Sedowofia

Barclay

Quaba

et al. 1998

Clinical Endocrinology

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Thermal injury results in the release of abnormally high levels of stress hormones in children. Although there are similarities between some of the data reported here and those reported in adults, higher levels of adrenaline and lower levels of noradrenaline than reported in adults suggest important differences too. These differences may need to be taken into account in the management of burn-injured children.

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Section: Discussioncontrasting

confidence: 66%

The systemic stress response to thermal injury in children

Sedowofia

Barclay

Quaba

et al. 1998

Clinical Endocrinology

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“…Surgical stress can increase post-operative plasma levels of catecholamines and cortisol, the major stress-induced hormones and cortisol has long been correlated with impaired human skin wound healing (Ebrecht et al, 2004). Normal circulating levels of epinephrine are reported to be 0.3-0.8 nmol/l in human plasma (Sedowofia et al, 1998) but increase by greater than tenfold (3-12 nmol/l) within the first 6 hours following injury (Crum et al, 1990;Matsui et al, 1991;Sedowofia et al, 1998). Since, we observed pro-motogenic, anti-contractile and pro-mitogenic effects in the nanomolar range in vitro and as this corresponds to the circulating levels seen in post trauma, our results may indeed be physiologically relevant.…”

Section: Discussionmentioning

confidence: 99%

The β2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms

Pullar

Isseroff

2006

Journal of Cell Science

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Dermal fibroblasts are required for skin wound repair; they migrate into the wound bed, proliferate, synthesize extracellular matrix components and contract the wound. Although fibroblasts express ␤ ␤2-adrenergic receptors (␤ ␤2-AR) and cutaneous keratinocytes can synthesize ␤ ␤-AR agonists (catecholamines), the functional significance of this hormonal mediator network in the skin has not been addressed. Emerging studies from our laboratory demonstrate that ␤ ␤2-AR activation modulates keratinocyte migration, essential for wound re-epithelialization. Here we describe an investigation of the effects of ␤ ␤2-AR activation on the dermal component of wound healing. We examined ␤ ␤2-AR-mediated regulation of biological processes in dermal fibroblasts that are critical for wound repair: migration, proliferation, contractile ability and cytoskeletal conformation.We provide evidence for the activation of at least two divergent ␤ ␤2-AR-mediated signaling pathways in dermal fibroblasts, a Src-dependent pro-migratory pathway, transduced through the epidermal growth factor receptor and extracellular signal-regulated kinase, and a PKAdependent pro-proliferative pathway. ␤ ␤2-AR activation attenuates collagen gel contraction and alters the actin cytoskeleton and focal adhesion distribution through PKAdependent mechanisms. Our work uncovers a previously unrecognized role for the adrenergic hormonal mediator network in the cutaneous wound repair process. Exploiting these divergent ␤ ␤2-AR agonist responses in cutaneous cells may generate novel therapeutic approaches for the control of wound healing.

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“…Demling et al showed a 15% reduction in CO despite an aggressive volume replacement protocol after a 40% scald burn in sheep [30]. However, there are also sustained increases in catecholamine secretion and elevated systemic vascular resistance for up to five days after burn injury [50,65]. Michie et al measured CO and SVR in anesthetized dogs resuscitated after burn injury [66].…”

Section: Hemodynamic Consequences Of Acute Burnsmentioning

confidence: 99%

“…Sympathetic stimulation and hypovolemia result in the release of catecholamines, vasopressin, angiotensin II, and neuropeptide-Y after burn injury [65,82]. These agents cause contraction of the arteriolar smooth muscle, which is systemically manifested by increased afterload and SVR.…”

Section: Increased Systemic Vascular Resistance and Organ Ischemiamentioning

confidence: 99%

Pathophysiology of burns

Keck

Herndon

Kamolz

et al. 2009

Wien Med Wochenschr

112

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Burn injury represents a significant problem worldwide. Advances in therapy strategies, based on better understanding of the pathophysiologic responses after burn injury have improved the clinical outcome of patients with burn injuries over the past years. This article describes the present understanding of the pathophysiology of a burn injury including both the local and systemic responses, focusing on the many facets of organ and systemic effects directly resulting from hypovolemia and circulating mediators following burn trauma.

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Cardiovascular and neurohumoral responses following burn injury

Cited by 8 publications

References 0 publications

The systemic stress response to thermal injury in children

The systemic stress response to thermal injury in children

The β2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergent mechanisms

Pathophysiology of burns

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