Cardiovascular and neurological toxicity of venlafaxine

Blythe, Donna; Lp, Hackett

doi:10.1191/096032799678840165

Cited by 52 publications

(36 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At therapeutic doses, it has minor effects on the reuptake of norepinephrine and dopamine, which is probably not clinically relevant [1]. Venlafaxine overdose has been reported to cause seizures, dysrythmias, central nervous system (CNS) depression, and hypotension [3,8].…”

Section: Discussionmentioning

confidence: 99%

A fatal case of venlafaxine overdose

2008

View full text Add to dashboard Cite

Introduction: Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects.Case Report: A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed significant QRS and QT C interval prolongation prior to his demise.Discussion: A literature review of venlafaxine overdose cases and investigation into its mechanism of action was conducted. The potential for sodium channel blockade and implications for therapy are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

A fatal case of venlafaxine overdose

2008

View full text Add to dashboard Cite

show abstract

“…7,15,16 Furthermore, this drug is known to cause serotonin syndrome in some cases. 17 The complaints were not related to metoprolol, which is also metabolized mainly by CYP2D6, see also Table 1. Metoprolol, a selective adrenergic beta-1-blocking agent, was prescribed to the patient because of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Depressive effect of an antidepressant: therapeutic failure of venlafaxine in a case lacking CYP2D6 activity

Wijnen¹,

Limantoro²,

Drent

et al. 2009

Ann Clin Biochem

View full text Add to dashboard Cite

Understanding the mechanisms of drug metabolism and interactions can help to prevent side-effects. Not only drug interactions, environmental factors, disease processes and ageing are factors in the inter-individual metabolic capacity variance but also genetic factors probably play an important role, as is illustrated in the case presented. Besides therapeutic drug monitoring, genotyping some important cytochrome P450 (CYP450) enzymes was of additional value in explaining why the patient developed severe adverse effects and, moreover, did not experience any therapeutical effect of venlafaxine. Results indicated that the patient was a poor metabolizer for CYP2D6, the most important phase I enzyme to metabolize venlafaxine. This corroborates that polymorphisms in the CYP450 gene influence the metabolic activity of the corresponding enzymes, thus affecting the subsequent serum drug levels and their metabolites. This case highlights the potential benefit of both clinical and genetic risk stratification ( pharmacogenetics) prior to treatment, either for setting the individual dose or for making a decision about using a particular drug.

show abstract

“…Major recognized side effects in cases of overdose are serotonin syndrome, seizures, sedation, and QRS and QT prolongation (1)(2)(3). This case report describes the formation of a tenacious gastric drug bezoar following intentional venlafaxine overdose.…”

Section: To the Editormentioning

confidence: 97%