Cardiovascular and renal effects of single administration of three different doses of isradipine in hypertensive patients

Rupoli, L.; Fruscio, M.; Gradnik, R.; Chianca, Roberto; Leonetti, Gastone; Zanchetti, Alberto

doi:10.1016/0002-9343(89)90193-9

Cited by 20 publications

(9 citation statements)

References 4 publications

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“…The present results demonstrate an increase in sodium excretion 1 to 3 h after oral administration of 5 mg isradipine in normotensive subjects, and an increase of urine volume after i to 2 h. The results are in accordance with other studies, in which increases in sodium excretion [6,7,9] and urine volume [6,9] were seen in essential hypertensive patients, but they are not fully in agreement with reports in which increases in sodium excretion [8] and urine volume [7,8] did not reach statistical significance.…”

Section: Discussionsupporting

confidence: 93%

“…GFR (except for a transient decrease in the first h after drug intake), RPF, RVR and FF remained unchanged throughout the 5 h of observation in accordance with some findings in hypertensive patients (GFR [7][8][9], RPF [7,9], FF [6,7]), but in contrast to others (increase of RPF [6,8], GFR [6]; decrease of FF [8], RVR [6]). In hypertensive patients RVR was decreased and PRF was increased after 20 mg nifedipine, whereas no effect was shown in normotensive patients [13].…”

Section: Discussionsupporting

confidence: 88%

“…PRA in essential hypertensive patients was either increased [8,9] or unchanged [3], and PAC was also unchanged [9]. There do not appear to be any reports about the renin-angiotensin system after isradipine administration to healthy controls.…”

Section: Discussionmentioning

confidence: 84%

“…The oral administration of 5 mg isradipine had no significant effect on blood pressure or heart rate in healthy, normotensive controls, whereas SBP and DBP were significantly howered by it in essential hypertensive patients [6--9], and heart rate was either unchanged [7,8] or increased [6,9]. Lederballe Pedersen et al [10] did not find a fall in blood pressure in normotensive controls after administration of nifedipine, despite a marked effect in hypertensive patients.…”

Section: Discussionmentioning

confidence: 98%

“…However, after 2 years of isradipine treatment (13.3 mg-d-1) GFR and RPF were no longer significantly increased; data for lithium clearance and renal vascular resistance were not given [7]. Persson et al [8] demonstrated an increase in RPF and no significant change in GFR or sodium excretion in hypertensive patients after 9 weeks on isradipine (15 mg-d-a), whereas Rupoli et al [9] demonstrated no change in GFR and PPF, but an increase in sodium excretion after acute administration of 2.5 to 7.5 mg isradipine in essential hypertensives.…”

mentioning

confidence: 99%

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Renal effects of the new calcium channel blocking drug isradipine

Krämer

Häussler

Ress

et al. 1990

Eur J Clin Pharmacol

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Summary. The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males.Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1-3 h after isradipine. Plasma renin activity showed a slight, insignificant increase i h after dosing. Uric acid clearance and 132-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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Renal effects of the new calcium channel blocking drug isradipine

Krämer

Häussler

Ress

et al. 1990

Eur J Clin Pharmacol

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Calcium‐Channel Entry Blocker Therapy for Hypertensive Patients with Concomitant Renal Impairment: A Focus on Isradipine

Frishman

1994

The Journal of Clinical Pharma

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In the treatment of hypertension in renally impaired patients, normalization of blood pressure alone may not be sufficient to prevent significant morbidity to the kidneys. Treatment must reduce pressure in the renal vasculature, otherwise glomerular filtration rate and renal plasma flow will continue to deteriorate. Isradipine a dihydropyridine calcium-channel blocker, has been investigated as a suitable treatment in this setting. Isradipine maintains glomerular filtration rate, preserves or enhances renal plasma flow, decreases renal vascular resistance, maintains or reduces filtration fraction, and exerts a sustained natriuretic effect, all of which may enable isradipine to slow the rate of progression of renal deterioration. In addition, isradipine may decrease proteinuria and may decrease glomerular capillary pressure by dilating both the efferent and afferent arterioles. Unlike older calcium-channel blockers, isradipine exhibits minimal cardiodepressant activity and is not associated with any negative inotropic effects. It is metabolized in the liver and dosage adjustments may not be necessary when administered to patients with renal insufficiency. Isradipine has a favorable renal effect profile and also has several properties that meet the requirements of other patient populations where an extra measure of antihypertensive safety is required, such as diabetics, dialysis patients, and transplant recipients. Side effects with isradipine are usually mild and transient, occurring in a dose-dependent manner.

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Kombinationstherapie mit anderen Therapieprinzipien

Fritschka¹,

Wehr²

1991

Kalziumantagonisten in Klinik Und Praxis

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Cardiovascular and renal effects of single administration of three different doses of isradipine in hypertensive patients

Cited by 20 publications

References 4 publications

Renal effects of the new calcium channel blocking drug isradipine

Renal effects of the new calcium channel blocking drug isradipine

Calcium‐Channel Entry Blocker Therapy for Hypertensive Patients with Concomitant Renal Impairment: A Focus on Isradipine

Kombinationstherapie mit anderen Therapieprinzipien

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