Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness

Bahous, Sola Aoun; Stephan, A; Blacher, Jacques; Safar, Michel E.

doi:10.1093/ndt/gfr578

Cited by 21 publications

(12 citation statements)

References 23 publications

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“…Normally, the link between the kidney and the large arterial system is tight and a recent study [13] has demonstrated that donor contribution to recipient outcome may go beyond age and gender, as previously suggested [30]. Furthermore, in the general population at large, and in the renal population in particular, there is a clear cross talk between the large arterial system and the kidney that is further amplified by age, which reflects the cumulative duration of the vascular-renal interaction.…”

Section: Discussionmentioning

confidence: 99%

“…Factors predicting or associated with graft function decline were mostly related to the recipient, and the only identified donor factors were age and gender. To our knowledge, other donor-related parameters, such as arterial function and renal function were not thoroughly evaluated in relation to graft function progression over time in the recipient despite recent findings linking recipient arterial stiffness to kidney function in the renal transplant population [10,11,12,13], and more specifically, donor aortic pulse wave velocity (PWV) with late post-transplant occurrence of cardiovascular events and graft failure [13]. …”

Section: Introductionmentioning

confidence: 99%

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Renal Function Decline in Recipients and Donors of Kidney Grafts: Role of Aortic Stiffness

et al. 2015

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Background/Aims: Renal function decreases over time as a result of reduction in the number of functioning nephrons with age. In recipients and donors of kidney grafts, renal function decline may be linked differently to various parameters, namely arterial stiffness. Methods: We conducted a prospective cohort study including 101 recipients of kidney grafts and their donors aiming at determining the factors correlated to the renal function decline over time. Aortic stiffness was evaluated by the non-invasive measurement of aortic pulse wave velocity. The glomerular filtration rate was estimated using the Modification of Diet in Renal Disease (MDRD) equation and the annualized change was determined. Results: Decline in renal function was estimated at 1-year post-transplantation and annually thereafter (median follow-up 8 years, range 3.6-18.3), as the mean of the annualized decrease in the glomerular filtration rate. In recipients, filtration rate decreased by 4.8 ± 19.7 ml/min/1.73 m² the first post-transplant year and at a yearly rate of 2.2 ± 3.8 ml/min/1.73 m² thereafter. The first-year decline was related to smoking and acute rejection. Later decline was significantly associated with donor age and aortic stiffness. In living donors, renal function decline after the first year corresponded to 0.7 ml/min/1.73 m², was significantly lower than that of recipients (p < 0.001), and was determined by donor age at nephrectomy. Conclusion: Recipients of kidney grafts show a glomerular filtration rate decline over time that is significantly associated with donor age and aortic stiffness after the first post-transplant year, while donors demonstrate a lower decline that is mostly determined by age at nephrectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renal Function Decline in Recipients and Donors of Kidney Grafts: Role of Aortic Stiffness

et al. 2015

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“…Consistent with prior literature in the general and HD populations, a history of CV events was the most significant correlate of future CV events during the 12month follow-up period. [20][21][22][23] Despite the major risk levied by the history of prior CV events, the change in cfPWV during 2 years retained significant association with the incidence of CV events. This association was consistently observed for both the time span between the two cfPWV measurements and the 1-year followup period, even following the adjustment for major CV risk factors including age, sex, active smoking, BP parameters, diabetes mellitus, hypercholesterolemia, and history of CV events.…”

Section: Discussionmentioning

confidence: 96%

“…Consistent with prior literature in the general and HD populations, a history of CV events was the most significant correlate of future CV events during the 12‐month follow‐up period . Despite the major risk levied by the history of prior CV events, the change in cfPWV during 2 years retained significant association with the incidence of CV events.…”

Section: Discussionmentioning

confidence: 99%

Change in Pulse Wave Velocity and Short‐Term Development of Cardiovascular Events in the Hemodialysis Population

Korjian

Daaboul

El-Ghoul

et al. 2016

J of Clinical Hypertension

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The association between single measurements of carotidfemoral pulse wave velocity (cfPWV) and cardiovascular (CV) events is driven by late events beyond 12 months of follow-up. This prospective study compares single measurements of cfPWV vs the 2-year delta cfPWV and the association with short-term development of CV events in hemodialysis patients. cfPWV was performed at t=0 and t=1 two years later, and patients were followed-up for development of CV events through 12 months (n=66). In Cox regression models adjusted for CV risk factors, history of CV events and delta cfPWV remained associated with the development of CV events (hazard ratio for prior CV events=8.9, P=.03; hazard ratio for delta cfPWV=1.14; P=.002). When delta cfPWV was substituted for single cfPWV measurement, none of the single measures were associated with new CV events. The change in cfPWV, but not single measurements of cfPWV, was associated with the development of CV events through 12 months.

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“…Recent studies have noted that BNP acts on the GC-A receptor of neighboring endothelial cells and possibly participates in coordinating endothelial regeneration/hypertrophy and the accompanying angiogenesis 3) . Donor large artery stiffness predicts a renal transplant recipient's cardiovascular and graft outcomes 4) . Aortic stiffness and increased wave reflections are independent predictors of cardiovascular events in renal transplant recipients 5) .…”

Section: Discussionmentioning

confidence: 99%

N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients

Chen

Lee

Lee³

et al. 2013

JAT

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Cardiovascular and renal outcome in recipients of kidney grafts from living donors: role of aortic stiffness

Cited by 21 publications

References 23 publications

Renal Function Decline in Recipients and Donors of Kidney Grafts: Role of Aortic Stiffness

Renal Function Decline in Recipients and Donors of Kidney Grafts: Role of Aortic Stiffness

Change in Pulse Wave Velocity and Short‐Term Development of Cardiovascular Events in the Hemodialysis Population

N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients

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