Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension

Somova, L; Nadar, Anand; Rammanan, P.; Shode, Francis O.

doi:10.1078/094471103321659807

Cited by 318 publications

(205 citation statements)

References 26 publications

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“…The seric levels of triacylglyceride from the rats that were treated with HE at all doses were reduced by 45.4, 49.6 and 51.47%, respectively. It is interesting to note that, as stated by Somova et al (2003), the ursolic and oleanolic acid obtained from the Syzygium presented diuretic activity, reduces two times more than the seric levels of tryglycerides, total cholesterol and lipoprotein fractions. The hematologic parameters are important ally of the studies toxicity, therefore the hematopoietic system is extremely sensible the activities of toxic agents, mainly those with mutagenic or cytotoxic potential, resulting in qualitative or quantitative alterations, transitory or permanent and that they can limit the use of medicines.…”

Section: Resultsmentioning

confidence: 99%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperitoneal route (i.p.) the HE (0.1 at 1 g/kg) caused death of the animals (LD50 of 0.489 g/kg). In rats, the HE (0.5, 1 and 2 g/kg, p.o.) did not cause any death, while by i.p., only the 2 g/kg dose was lethal to 67% of the animals. To evaluate chronic toxicity, groups of rats daily received the HE (0.05, 0.1 and 0.25 g/kg) through p.o., during 30, 90 or 180 days and the effects on behavior, body weight, feed consumed were measured. Histology, hematology and biochemical parameters were measured at the end of the treatment. After a 30-day treatment, the HE caused changes in some biochemical parameters. Histological examination of the liver, kidneys, lungs, heart, stomach, intestine and pancreas showed normal architecture suggesting no morphological disturbances. These data may mean that the HE of S. cumini does not exert acute or chronic toxic effects by oral administration.

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Section: Resultsmentioning

confidence: 99%

The toxicity evaluation of Syzygium cumini leaves in rodents

Silva¹,

Abreu²,

Silva³

et al. 2012

Rev. bras. farmacogn.

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“…Among them, the triterpenoid compounds, BA and OA, had increased atrial dynamics with stimulation of atrial natriuretic peptide secretion in isolated beating rabbit atrium (data not shown). In addition, Somova et al showed that OA and UA had vasodepressor, antidysrhythmic, and cardiotonic effects in rats, 11 and UA, the structural isomer of OA, enhanced cardiac contractility via Na + /K + -ATPase activity. 16 These findings suggest that the triterpenoids might be involved in ELT-induced increase in atrial dynamics in beating rabbit atria.…”

Section: Discussionmentioning

confidence: 99%

“…9 Further, some active components including triterpenoids (ursolic acid [UA], oleanolic acid [OA], and betulinic acid [BA]) and polysaccharides that were found in the leaves of Lycopus lucidus Turcz and have been shown to decrease heart rates in rats and improved the immune system in mice. 10,11 In a screening study of cardioactive principles from TOM, we found that the herb L. lucidus has significant cardiotonic activity. Although L. lucidus has been known to be used for the treatment of cardiovascular disease, few studies have investigated its pharmacological activities and mechanisms of actions on cardiac contractility.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extract ofLycopus lucidusElicits Positive Inotropic Effect Via Activation of Ca²⁺Entry and Ca²⁺Release in Beating Rabbit Atria

Cui

et al. 2013

Journal of Medicinal Food

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Lycopus lucidus Turcz has been widely used as a traditional Oriental medicine (TOM) in Korea and China and prescribed for the enhancement of heart function. However, the precise effects have yet to be defined. The purpose of the present study was, therefore, to address whether the ethanol extract of Lycopus lucidus Turcz (ELT) has a positive inotropic effect. ELT-induced changes in atrial mechanical dynamics (pulse pressure, dp/dt, and stroke volume), and cAMP efflux were measured in perfused beating rabbit atria. Three active components, rosmarinic acid, betulinic acid, and oleanolic acid were identified in ELT by high performance liquid chromatography analysis. ELT increased atrial dynamics in a concentration-dependent manner without changes in atrial cAMP levels and cAMP efflux. The ELTinduced positive inotropic effect was blocked by inhibition of the L-type Ca 2 + channels and sarcoplasmic reticulum (SR). Inhibitors of b-adrenoceptors had no effect on the ELT-induced positive inotropic effect. The results suggest that ELT exerts a positive inotropic effect via activation of Ca 2 + entry through L-type Ca 2 + channel and Ca 2 + release from the SR in beating rabbit atria.

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“…These triterpenic acids have also been reported as displaying various biological, pharmacological and medical activities such as anti-inflammatory [2], hepatoprotective, gastroprotective [3], anti-HIV [4], cardiovascular, hypolipidemic [5] or immunoregulatory [6]. They have also been found to be active in various stages of tumor development, including inhibition of tumor promotion, invasion and metastasis [7], and have been found to be effective inhibitors of tumor angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

The effect of ursolic and oleanolic acids on human skin fibroblast cells

Wójciak–Kosior¹,

Paduch²,

Matysik-Woźniak³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:In this article, we look at how ursolic and oleanolic acids can be used for the purpose of quality control of natural products used in dermatocosmetology as well as of various other therapeutic preparations. Ursolic acid (UA) and oleanolic acid (OA) are pentacyclic triterpenes and they are constituents of many medicinal herbs. In this study, we analyzed the cytotoxic and anti-proliferative activity of OA and UA against normal human skin fibroblasts (HSF). Additionally, the scavenging activity of free radicals of both acids was analyzed. The sensitivity of cells to OA and UA activity was determined using a standard spectrophotometric (MTT) assay. The free radical scavenging activity of OA and UA was measured using the DPPH• test. The F-actin cytoskeletal proteins organization was analyzed using TRITC-phalloidine fluorescent staining. The cytotoxic activity of the analyzed acids was determined using Neutral Red (NR) uptake assay. Of the two isomeric compounds, UA showed a higher cytotoxic activity against HSF cells than did OA. Our investigations showed that OA, in view of its non-toxic nature, may be used as a supplementary factor for dermal preparations.

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Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension

Cited by 318 publications

References 26 publications

The toxicity evaluation of Syzygium cumini leaves in rodents

The toxicity evaluation of Syzygium cumini leaves in rodents

Ethanol Extract ofLycopus lucidusElicits Positive Inotropic Effect Via Activation of Ca²⁺Entry and Ca²⁺Release in Beating Rabbit Atria

The effect of ursolic and oleanolic acids on human skin fibroblast cells

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Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension

Cited by 318 publications

References 26 publications

The toxicity evaluation of Syzygium cumini leaves in rodents

The toxicity evaluation of Syzygium cumini leaves in rodents

Ethanol Extract ofLycopus lucidusElicits Positive Inotropic Effect Via Activation of Ca2+Entry and Ca2+Release in Beating Rabbit Atria

The effect of ursolic and oleanolic acids on human skin fibroblast cells

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Product

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Ethanol Extract ofLycopus lucidusElicits Positive Inotropic Effect Via Activation of Ca²⁺Entry and Ca²⁺Release in Beating Rabbit Atria