Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Ghanbari, Hossein; Mel, Achala de; Seifalian, Alexander M.

doi:10.2147/ijn.s14881

Cited by 40 publications

(8 citation statements)

References 65 publications

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“…The biomedical applications of POSS arise from the materials biocompatibility, biostability nontoxicity, cytocompatibility, and resistance to degradation [91–93]. It is due to these properties that POSS has been incorporated into wide range of nanostructured copolymers for a number of biomedical applications such as biomedical devices (heart valves, coronary stents) [94, 95], drug delivery [96], and tissue engineering [92]. …”

Section: Construction Of a Tissue Scaffoldmentioning

confidence: 99%

Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response

Poinern

Ali

et al. 2013

International Journal of Biomaterials

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Surface topographical features on biomaterials, both at the submicrometre and nanometre scales, are known to influence the physicochemical interactions between biological processes involving proteins and cells. The nanometre-structured surface features tend to resemble the extracellular matrix, the natural environment in which cells live, communicate, and work together. It is believed that by engineering a well-defined nanometre scale surface topography, it should be possible to induce appropriate surface signals that can be used to manipulate cell function in a similar manner to the extracellular matrix. Therefore, there is a need to investigate, understand, and ultimately have the ability to produce tailor-made nanometre scale surface topographies with suitable surface chemistry to promote favourable biological interactions similar to those of the extracellular matrix. Recent advances in nanoscience and nanotechnology have produced many new nanomaterials and numerous manufacturing techniques that have the potential to significantly improve several fields such as biological sensing, cell culture technology, surgical implants, and medical devices. For these fields to progress, there is a definite need to develop a detailed understanding of the interaction between biological systems and fabricated surface structures at both the micrometre and nanometre scales.

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Section: Construction Of a Tissue Scaffoldmentioning

confidence: 99%

Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response

Poinern

Ali

et al. 2013

International Journal of Biomaterials

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“…While being viscoelastic, polyhedral-oligomeric-silsesquioxane-poly(carbonate-urea)urethane (POSS-PCU) has been shown to have strength similar to natural arteries. POSS-nanocomposite polymer, used for cardiovascular implants, which include vascular bypass grafts, stents, and heart valves has been proved to have antithrombogenic properties [ 29 ].…”

Section: Surface Modification Of Blood Contacting Materialsmentioning

confidence: 99%

Surface Modification of Biomaterials: A Quest for Blood Compatibility

Mel

Cousins

Seifalian

2012

International Journal of Biomaterials

104

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Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency. These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated. Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility. A great deal of research efforts are attributed towards realising such a surface, which comprise of a range of methods on surface modification. Surface modification methods can be broadly categorized as physicochemical modifications and biological modifications. These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium. Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.

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“…Studies have shown that the incorporation of POSS molecules into various polymers can influence their thermal stability and degradation behaviour at elevated temperatures, change the glass transition temperature, increase the resistance to composite oxidation, and improve mechanical strength [ 22 , 25 , 26 , 27 ]. Among different POSS-containing polymer materials, hybrid PU-POSS elastomers of various architectures have been widely studied in the literature [ 17 , 18 , 19 , 28 , 29 , 30 , 31 ], but PU foam chemically reinforced by POSS constitutes a new class of materials.…”

Section: Introductionmentioning

confidence: 99%

Composites of Rigid Polyurethane Foams Reinforced with POSS

et al. 2019

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Rigid polyurethane foams (RPUFs) were successfully modified with different weight ratios (0.5 wt%, 1.5 wt% and 5 wt%) of APIB-POSS and AEAPIB-POSS. The resulting foams were evaluated by their processing parameters, morphology (Scanning Electron Microscopy analysis, SEM), mechanical properties (compressive test, three-point bending test and impact strength), viscoelastic behavior (Dynamic Mechanical Analysis, DMA), thermal properties (Thermogravimetric Analysis, TGA, and thermal conductivity) and application properties (contact angle, water absorption and dimensional analysis). The results showed that the morphology of modified foams is significantly affected by the type of the filler and filler content, which resulted in inhomogeneous, irregular, large cell shapes and further affected the physical and mechanical properties of resulting materials. RPUFs modified with APIB-POSS represent better mechanical and thermal properties compared to the RPUFs modified with AEAPIB-POSS. The results showed that the best results were obtained for RPUFs modified with 0.5 wt% of APIB-POSS. For example, in comparison with unfilled foam, compositions modified with 0.5 wt% of APIB-POSS provide greater compression strength, better flexural strength and lower water absorption.

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Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Cited by 40 publications

References 65 publications

Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response

Engineering a Biocompatible Scaffold with Either Micrometre or Nanometre Scale Surface Topography for Promoting Protein Adsorption and Cellular Response

Surface Modification of Biomaterials: A Quest for Blood Compatibility

Composites of Rigid Polyurethane Foams Reinforced with POSS

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