Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism

Kim, Joong‐Seok; Ryu, Dong-Woo; Oh, Ju‐Hee; Lee, Yang Hyun; Park, Sung Jin; Jeon, Kipyung; Lee, Jong Yun; Ho, Seong Hee; So, Jungmin; Im, Jin Hee; Lee, Kwang Soo

doi:10.3988/jcn.2017.13.1.15

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…In other words, insufficient VEGF increases arterial stiffness whereas excessive VEGF increases permeability, thereby, decreasing vascular stiffness. In this context, it is interesting to note that patients with PD show elevated CSF VEGF and reduced arterial stiffness [ 2 , 28 , 105 , 106 , 107 , 108 ].…”

Section: Vegf Signaling In Age-related Neurological Disordersmentioning

confidence: 99%

VEGF Signaling in Neurological Disorders

Shim

Madsen

2018

IJMS

117

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Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, we discovered that a heparin binding epidermal growth factor like growth factor (HB-EGF)—a class of EGF receptor (EGFR) family ligands—contributes to the development of hydrocephalus with subarachnoid hemorrhage through activation of VEGF signaling. The objective of this review is to entail a recent update on causes of death due to neurological disorders involving cerebrovascular and age-related neurological conditions and to understand the mechanism by which angiogenesis-dependent pathological events can be treated with VEGF antagonisms. The Global Burden of Disease study indicates that cancer and cardiovascular disease including ischemic and hemorrhagic stroke are two leading causes of death worldwide. The literature suggests that VEGF signaling in ischemic brains highlights the importance of concentration, timing, and alternate route of modulating VEGF signaling pathway. Molecular targets distinguishing two distinct pathways of VEGF signaling may provide novel therapies for the treatment of neurological disorders and for maintaining lower mortality due to these conditions.

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Section: Vegf Signaling In Age-related Neurological Disordersmentioning

confidence: 99%

VEGF Signaling in Neurological Disorders

Shim

Madsen

2018

IJMS

117

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“…Age-matched PD patients newly diagnosed during the same period also were enrolled. DIP was defined using the following criteria: (1) presence of at least two of the four cardinal parkinsonian signs (tremor, rigidity, bradykinesia, and impaired postural reflexes); (2) absence of a personal history of extrapyramidal disorders before treatment with an offending drug; (3) onset of symptoms during the course of treatment with an offending drug; and (4) reversal of parkinsonian symptoms, although not necessarily completely, after discontinuation of the offending drug during follow-up of more than 6 months 19 , 20 . All DIP patients showed normal dopamine transporter uptake on a visual analysis of positron emission tomography (PET) with 18 F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane ( 18 F-FP-CIT).…”

Section: Methodsmentioning

confidence: 99%

Decreased thalamic monoamine availability in drug-induced parkinsonism

Yoo

Lyoo

et al. 2022

Sci Rep

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Drug-induced parkinsonism (DIP) is caused by a dopamine receptor blockade and is a major cause of misleading diagnosis of Parkinson’s disease (PD). Striatal dopamine activity has been investigated widely in DIP; however, most studies with dopamine transporter imaging have focused on the clinical characteristics and prognosis. This study investigated differences in striatal subregional monoamine availability among patients with DIP, normal controls, and patients with early PD. Thirty-five DIP patients, the same number of age-matched PD patients, and 46 healthy controls were selected for this study. Parkinsonian motor status was examined. Brain magnetic resonance imaging and positron emission tomography with 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane were performed, and the regional standardized uptake values were analyzed with a volume-of-interest template and compared among the groups. The groups were evenly matched for age, but there were numerically more females in the DIP group. Parkinsonian motor symptoms were similar in the DIP and PD groups. Monoamine availability in the thalamus of the DIP group was lower than that of the normal controls and similar to that of the PD group. In other subregions (putamen, globus pallidus, and ventral striatum), monoamine availability in the DIP group and normal controls did not differ and was higher than that in the PD group. This difference compared to healthy subject suggests that low monoamine availability in the thalamus could be an imaging biomarker of DIP.

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“…However, because DIP is sometimes clinically indistinguishable from PD, diagnosis is challenging. 4 5 6 7 …”

Section: Introductionmentioning

confidence: 99%

Retinal Thickness and Its Interocular Asymmetry Between Parkinson’s Disease and Drug-Induced Parkinsonism

Suh

Baek

et al. 2023

J Korean Med Sci

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Background Drug-induced parkinsonism (DIP) is common, but diagnosis is challenging. Although dopamine transporter imaging is useful, the cost and inconvenience are problematic, and an easily accessible screening technique is needed. We aimed to determine whether optical coherence tomography (OCT) findings could differentiate DIP from Parkinson’s disease (PD). Methods We investigated 97 de novo PD patients and 27 DIP patients using OCT and [ 18 F] N-(3-fluoropropyl)-2b-carbon ethoxy-3b-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography. We compared peripapillary retinal nerve fiber layer thickness (pRNFLT) and macular retinal thickness (mRT) between PD and DIP patients as well as interocular differences in the pRNFLT and the mRT. Asymmetric index (%) for retinal thickness (AIRT) was calculated to measure the interocular differences between pRNFLT and mRT. The correlation between AIRT and total striatal specific/non-specific binding ratio asymmetry index (SNBRAI) was investigated in PD and DIP patients. Results No significant differences in pRNFLT and mRT values were observed between PD and DIP patients (all P values > 0.090). The mean SNBRAI was significantly higher in PD than in DIP ( P = 0.008) patients; however, AIRT did not differ between PD and DIP patients in pRNFLT and mRT (all P values > 0.100). SNBRAI did not correlate with AIRT of pRNFL or mRT in PD and DIP patients (all P values > 0.060). Conclusion Our study showed no benefit of retinal thickness and interocular asymmetry measurements using OCT for distinguishing PD from DIP in the early stages. Additional investigations are needed for confirmation.

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Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism

Cited by 8 publications

References 39 publications

VEGF Signaling in Neurological Disorders

VEGF Signaling in Neurological Disorders

Decreased thalamic monoamine availability in drug-induced parkinsonism

Retinal Thickness and Its Interocular Asymmetry Between Parkinson’s Disease and Drug-Induced Parkinsonism

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