Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls

Kim, Joong‐Seok; Oh, Yoon‐Sang; Park, Hyung-Eun; Lee, Sihoon; Park, Jeong‐Wook; Song, In‐Uk; An, Jae-Young; Park, Hun‐Jun; Son, Byung-chul; Lee, Kwang Soo

doi:10.1007/s10072-015-2465-x

Cited by 9 publications

(20 citation statements)

References 22 publications

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“…One study defining motor subtype showed less HRV impairment in TDPD patients than patients with akinetic-rigid dominant PD. [16] In another study comparing drug-naive ET patients with controls, there were no differences in the HRV frequency domains between the two groups [23]. While this is in line with our own results, the methodology used in that study did not adhere to the recommendations of the task force [24].…”

Section: Discussionsupporting

confidence: 71%

Heart rate variability to differentiate essential tremor from early-stage tremor-dominant Parkinson's disease

Yoon

Kim

Lee

et al. 2016

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 71%

Heart rate variability to differentiate essential tremor from early-stage tremor-dominant Parkinson's disease

Yoon

Kim

Lee

et al. 2016

Journal of the Neurological Sciences

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“…Kim et al reported that ET cases displayed more orthostatic symptoms than controls but the frequency of OH in younger ET patients was similar to that of normal controls. 10 Nonetheless, Damian et al found that with the exception of sialorrhea, there were no autonomic symptoms in ET cases. 11 Thus, the issue of autonomic dysfunction in ET cases is still a topic of debate and reports addressing OH in the cases are scarce.…”

Section: Introductionmentioning

confidence: 98%

Orthostatic Hypotension in Elderly Patients with Essential Tremor

Kaya¹,

Aydın²,

Işık³

2021

CIA

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Purpose: Essential tremor (ET) is the most common movement disorder in which dysautonomia symptoms can be present. We aimed to evaluate the presence of orthostatic hypotension (OH) and its relationship with the clinical features. Patients and Methods: Forty-four elderly patients with ET and 118 healthy elderly controls were included. OH was assessed via the head-up tilt table test and defined, according to the change in position, as a drop of at least 20 mmHg in systolic blood pressure and/or 10 mmHg in diastolic blood pressure. Tremor severity was evaluated using the Fahn-Tolosa-Marin Tremor Rating (FTMTR) Scale. All patients underwent geriatric comprehensive assessment. Results: There were no differences between the controls and patients with ET regarding age and gender. The mean age was 72.8±6.1, the mean disease duration 19.1±13.5 years and the mean FTMTR score was 30.9±17.1 in patients with ET. The frequency of OH at the 1st minute in patients with ET was higher than in controls (31.8% vs 17.8%, p=0.046). Furthermore, the frequency of jaw tremor in patients with OH was higher than in those without OH (35.7% vs 6.7%, p=0.025). About 28.6% of ET patients with OH had orthostatic symptoms. Conclusion:We demonstrated that ET patients, particularly those with jaw tremors, had OH and that most of them were asymptomatic. Therefore, in order to protect patients from complications related to OH, it would be appropriate to evaluate OH in the follow-up and treatment of elderly patients with ET.

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“…Obesity is known to contribute to the development of cardiomyopathy. 3,[24][25][26][27] Although the underlying mechanism has been studies F I G U R E 7 MD-1 mediated high-fat diet-induced cardiac pathological remodelling via negatively regulating MAPK and NF-κB signalling. (A, C) Western blot analysis for the phosphorylation levels of MEK, ERK, JNK, p38, IκBα and p65, relative to levels of the total one, in MD-1 −/− hearts and wild-type (WT) mice hearts after high-fat diet feed for 20 wk.…”

Section: Discussionmentioning

confidence: 99%

Myeloid differentiation protein 1 protected myocardial function against high‐fat stimulation induced pathological remodelling

Shen

Kong

Shuai

et al. 2019

J Cellular Molecular Medi

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Myeloid differentiation 1 (MD‐1) is a secreted protein that regulates the immune response of B cell through interacting with radioprotective 105 (RP105). Disrupted immune response may contribute to the development of cardiac diseases, while the roles of MD‐1 remain elusive. Our studies aimed to explore the functions and molecular mechanisms of MD‐1 in obesity‐induced cardiomyopathy. H9C2 myocardial cells were treated with free fatty acid (FFA) containing palmitic acid and oleic acid to challenge high‐fat stimulation and adenoviruses harbouring human MD‐1 coding sequences or shRNA for MD‐1 overexpression or knockdown in vitro. MD‐1 overexpression or knockdown transgenic mice were generated to assess the effects of MD‐1 on high‐fat diet (HD) induced cardiomyopathy in vivo. Our results showed that MD‐1 was down‐regulated in H9C2 cells exposed to FFA stimulation for 48 hours and in obesity mice induced by HD for 20 weeks. Both in vivo and in vitro , silencing of MD‐1 accelerated myocardial function injury induced by HD stimulation through increased cardiac hypertrophy and fibrosis, while overexpression of MD‐1 alleviated the effects of HD by inhibiting the process of cardiac remodelling. Moreover, the MAPK and NF‐κB pathways were overactivated in MD‐1 deficient mice and H9C2 cells after high‐fat treatment. Inhibition of MAPK and NF‐κB pathways played a cardioprotective role against the adverse effects of MD‐1 silencing on high‐fat stimulation induced pathological remodelling. In conclusion, MD‐1 protected myocardial function against high‐fat stimulation induced cardiac pathological remodelling through negative regulation for MAPK/NF‐κB signalling pathways, providing feasible strategies for obesity cardiomyopathy.

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Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls

Cited by 9 publications

References 22 publications

Heart rate variability to differentiate essential tremor from early-stage tremor-dominant Parkinson's disease

Heart rate variability to differentiate essential tremor from early-stage tremor-dominant Parkinson's disease

Orthostatic Hypotension in Elderly Patients with Essential Tremor

Myeloid differentiation protein 1 protected myocardial function against high‐fat stimulation induced pathological remodelling

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