Cardiovascular changes under the microgravity environment and the gut microbiome

Siddiqui, Ruqaiyyah; Qaisar, Rizwan; Al-Dahash, Khulood; Altelly, Ahmad Hashem; Elmoselhi, Adel B; Khan, Naveed Ahmed

doi:10.1016/j.lssr.2023.09.003

Cited by 3 publications

(4 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Astronauts, especially during long term flights, face an increased risk for cardiac arrhythmias ( Fritsch-Yelle et al, 1998 ; Anzai et al, 2014 ; Zhu et al, 2015 ; Popova and Rusanov, 2023 ). This is currently regarded by the NASA as one of the leading cardiovascular risks for long term space flight, e.g., to Mars ( Patel et al, 2020 ; Siddiqui et al, 2024 ). The mechanisms inducing cardiac arrhythmias in astronauts, i.e., the acute triggers, have not been clearly identified yet ( Popova and Rusanov, 2023 ; Siddiqui et al, 2024 ).…”

Section: Discussionmentioning

confidence: 99%

“…This is currently regarded by the NASA as one of the leading cardiovascular risks for long term space flight, e.g., to Mars ( Patel et al, 2020 ; Siddiqui et al, 2024 ). The mechanisms inducing cardiac arrhythmias in astronauts, i.e., the acute triggers, have not been clearly identified yet ( Popova and Rusanov, 2023 ; Siddiqui et al, 2024 ). Amongst others, cardiac deconditioning, electrolyte disorders, fluid shifts, psychological stress, altered levels of catecholamines, cosmic radiation, bradycardia, T-wave alternans, the use of QT prolonging drugs or heavy work are currently discussed to contribute ( Anzai et al, 2014 ; Zhu et al, 2015 ; Popova and Rusanov, 2023 ; Siddiqui et al, 2024 ).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms inducing cardiac arrhythmias in astronauts, i.e., the acute triggers, have not been clearly identified yet ( Popova and Rusanov, 2023 ; Siddiqui et al, 2024 ). Amongst others, cardiac deconditioning, electrolyte disorders, fluid shifts, psychological stress, altered levels of catecholamines, cosmic radiation, bradycardia, T-wave alternans, the use of QT prolonging drugs or heavy work are currently discussed to contribute ( Anzai et al, 2014 ; Zhu et al, 2015 ; Popova and Rusanov, 2023 ; Siddiqui et al, 2024 ). Our current study suggests that the mechanical unloading due to microgravity during space travel may also induce a cardiac remodeling that could causally contribute to the increased arrhythmic load, implying potential new targets for the prevention.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ventricular unloading causes prolongation of the QT interval and induces ventricular arrhythmias in rat hearts

Schwoerer,

Biermann,

Ehmke

2024

Front. Physiol.

View full text Add to dashboard Cite

IntroductionVentricular unloading during prolonged bed rest, mechanical circulatory support or microgravity has repeatedly been linked to potentially life-threatening arrhythmias. It is unresolved, whether this arrhythmic phenotype is caused by the reduction in cardiac workload or rather by underlying diseases or external stimuli. We hypothesized that the reduction in cardiac workload alone is sufficient to impair ventricular repolarization and to induce arrhythmias in hearts.MethodsRat hearts were unloaded using the heterotopic heart transplantation. The ECG of unloaded and of control hearts were telemetrically recorded over 56 days resulting in >5 × 106 cardiac cycles in each heart. Long-term electrical remodeling was analyzed using a novel semi-automatic arrhythmia detection algorithm.Results56 days of unloading reduced left ventricular weight by approximately 50%. While unloading did not affect average HRs, it markedly prolonged the QT interval by approximately 66% and induced a median tenfold increase in the incidence of ventricular arrhythmias in comparison to control hearts.ConclusionThe current study provides direct evidence that the previously reported hypertrophic phenotype of repolarization during cardiac unloading translates into an impaired ventricular repolarization and ventricular arrhythmias in vivo. This supports the concept that the reduction in cardiac workload is a causal driver of the development of arrhythmias during ventricular unloading.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ventricular unloading causes prolongation of the QT interval and induces ventricular arrhythmias in rat hearts

Schwoerer,

Biermann,

Ehmke

2024

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Cardiac myocyte atrophy, characterized by a reduction in cardiomyocyte size and contractile function, is another consequence of prolonged microgravity exposure [64]. This atrophic remodeling is thought to result from altered cardiac loading conditions and reduced metabolic demands in the microgravity environment [65]. The absence of mutations in the phosphatidylinositol-4,5-bisphosphate 3kinase catalytic subunit alpha (PIK3CA) gene and the presence of a " PTEN-less" phenotype -characterized by loss or inactivation of the phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) genemay contribute to the maintenance of cardiac myocyte structure and function, potentially serving as biomarkers for resilience against cardiac myocyte atrophy.…”

Section: Cardiovascular System Resilience Biomarkersmentioning

confidence: 99%

Potential Biomarkers of Resilience to Microgravity Hazards in Astronauts

Minoretti,

Fontana,

Lavdas

et al. 2024

Cureus

View full text Add to dashboard Cite

Space exploration exposes astronauts to the unique environment of microgravity, which poses significant health challenges. Identifying biomarkers that can predict an individual’s resilience to the stressors of microgravity holds great promise for optimizing astronaut selection and developing personalized countermeasures. This narrative review examines the principal health risks associated with microgravity and explores potential biomarkers indicative of resilience. The biomarkers being evaluated represent a broad spectrum of physiological domains, including musculoskeletal, neurological, immunological, gastrointestinal, cardiovascular, and cutaneous systems. Earth-based microgravity analogs, such as dry immersion and head-down tilt bed rest, may provide valuable platforms to validate candidate biomarkers. However, biomarker sensitivity and specificity must be further evaluated to ensure efficacy and reliability. Establishing a panel of biomarkers predictive of resilience to microgravity-induced health risks would significantly enhance astronaut health and mission success, especially for long-duration exploration missions. Insights gained may also translate to health conditions on Earth characterized by reduced physical activity and mechanical loading.

show abstract

Mesenchymal stem cells arouse myocardial NAD+ metabolism to alleviate microgravity-induced cardiac dysfunction

Zhang,

Yuan,

Zhang

et al. 2024

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Cardiovascular changes under the microgravity environment and the gut microbiome

Cited by 3 publications

References 90 publications

Ventricular unloading causes prolongation of the QT interval and induces ventricular arrhythmias in rat hearts

Ventricular unloading causes prolongation of the QT interval and induces ventricular arrhythmias in rat hearts

Potential Biomarkers of Resilience to Microgravity Hazards in Astronauts

Mesenchymal stem cells arouse myocardial NAD+ metabolism to alleviate microgravity-induced cardiac dysfunction

Contact Info

Product

Resources

About