Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan

Hua, Tuan-Chun; Chung, Pei I.; Chen, Yi Ju; Wu, Li-Chiu; Chen, Yen Da; Hwang, Chian Yaw; Chu, Szu Yin; Chen, Chih Chiang; Lee, Ding Dar; Chang, Yun Ting; Liu, Han Nan

doi:10.1016/j.jaad.2015.04.028

Cited by 113 publications

(117 citation statements)

References 22 publications

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“…This corroborates recent findings of Thyssen et al which also found patients with rosacea were not more likely to have an independent risk of CVD or an increase in CVD risk factors (high cholesterol, LDL, and CRP) and environmental habits (increased smoking and drinking) [24]. A Taiwanese study did find that rosacea was significantly associated with CV comorbidities including dyslipidemia, hypertension, and coronary artery disease, although it lacked adjustment for important CV risk factors such as smoking and alcohol abuse [25]. …”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Marshall

Moustafa

Hawkins

et al. 2016

Dermatol Ther (Heidelb)

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IntroductionInflammation is an established component of cardiovascular disease (CVD) and an underlying factor of several dermatologic conditions including rosacea, atopic dermatitis, and psoriasis. Identifying potential associations between these dermatologic and cardiovascular diseases can better inform holistic healthcare approaches. The objective of this study was to determine whether rosacea, psoriasis or atopic dermatitis are independent risk factors for CVD 1 year following diagnosis.MethodsUsing a large commercial claims database of 21,801,147 lives, we employed a propensity-matched logistic regression to evaluate the association between diagnoses of rosacea, psoriasis, or atopic dermatitis and a 1-year risk of being diagnosed with cardiovascular disease. Control patients were matched based on health-care utilization, age and overall health status as defined by a modified Deyo–Charlson comorbidity index.ResultsThe analysis included 2105 rosacea, 622 atopic dermatitis, 1536 psoriasis, and 4263 control patients. Compared to propensity-matched controls, the adjusted odds of cardiovascular disease were not higher in patients with rosacea (odds ratio: 0.894, p = 0.2713), atopic dermatitis (OR 1.032, p = 0.8489), or psoriasis (OR 1.087, p = 0.4210). In univariate analysis, the unadjusted odds of cardiovascular disease was higher in patients with psoriasis (OR 1.223, p = 0.0347).ConclusionsLimitations of this study include the short follow-up period and inclusion of only commercially insured patients limit the generalizability of these findings. In this large study of patients with rosacea, atopic dermatitis, and psoriasis, we did not detect an increased 1-year risk of cardiovascular disease after adjusting for confounders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-016-0144-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Marshall

Moustafa

Hawkins

et al. 2016

Dermatol Ther (Heidelb)

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“…However, personal information, such as bodyweight, family history, lifestyle and habits, including smoking and alcohol consumption, is not available from this database. Our published studies have already shown that this database is suitable for the use in epidemiological researches …”

Section: Methodsmentioning

confidence: 99%

Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case–control study in Taiwan

Chung

et al. 2016

The Journal of Dermatology

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The association between sarcoidosis and autoimmune comorbidities has been reported, however, it has seldom been confirmed by a large nationwide study. Our study aimed to clarify the association between sarcoidosis and autoimmune comorbidities in the Taiwanese. A total of 1237 patients with sarcoidosis and 4948 age- and sex-matched control subjects were selected from the National Health Insurance Research Database of Taiwan from 1997 to 2010. Multiple logistic regressions were performed to calculate the odds of comorbidities between the two groups. The prevalence of sarcoidosis was 2.17/100 000 individuals in Taiwan. Sarcoidosis patients tended to run a higher risk of autoimmune comorbidities than the control group (17.6% vs 9.4%, P < 0.05). Autoimmune thyroid disease (adjusted odd ratio [aOR], 1.32; 95% confidence interval [CI], 1.05-1.64), Sjögren's syndrome (aOR, 11.6; 95% CI, 4.36-31.0) and ankylosing spondylitis (aOR, 3.80; 95% CI, 2.42-5.97) were significantly associated with sarcoidosis. The sex-stratified analyses were carried out to demonstrate a significant association of sarcoidosis with ankylosing spondylitis in both sexes, but with autoimmune thyroid disease in male patients and with Sjögren's syndrome female patients, respectively. Besides, the diagnosis of the autoimmune comorbidities strongly associated with sarcoidosis tended to be established after that of sarcoidosis. This study demonstrated that patients with sarcoidosis tended to have autoimmune thyroid disease, Sjögren's syndrome and ankylosing spondylitis, and the diagnosis of sarcoidosis usually preceded that of associated comorbidities. Clinicians should be alert to autoimmune comorbidities in patients with sarcoidosis.

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“…The same conclusion was reached by Hua TC et al in 2015: RS patients have a higher risk to develop hypertension, dyslipidemia et coronary disease (33). Rainer BM et al also stated in one poster that severe RS forms have a higher risk for essential hypertension (34).…”

Section: Results Resultsmentioning

confidence: 59%

Rosacea and its comorbidities

Merticariu¹,

Marinescu²,

Giurcăneanu³

2016

JTMR

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Objectives: Rosacea is currently defined as an inflammatory cutaneous disease without systemic echoes. The objective of our paper is to review the published articles to confirm our belief that rosacea is associated to or can predispose to various diseases, mainly inflammatory diseases. Material and methods:Review all the papers published in the last two decades in PubMed, Google Academic and Medscape databases, linking rosacea and various disorders of the body systems. Results: We found that rosacea is associated to several illnesses of major systems (gastrointestinal, cardiovascular, respiratory) and that there are also links between rosacea and immune system disorders and psychiatric diseases. Rosacea clinical course can be influenced by various drugs prescribed for the previous mentioned diseases. Conclusions: Rosacea should no longer be considered a localized cutaneous condition but rather a complex pathology with systemic reverberation. Patients suffering of severe forms of rosacea for a long period of time should have a careful evaluation of body systems.

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Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan

Cited by 113 publications

References 22 publications

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Cardiovascular Disease Outcomes Associated with Three Major Inflammatory Dermatologic Diseases: A Propensity-Matched Case Control Study

Comorbid autoimmune diseases in patients with sarcoidosis: A nationwide case–control study in Taiwan

Rosacea and its comorbidities

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