Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea

Jung, Hye Jung; Lee, Dong Heon; Park, Mi Youn; Ahn, Jong Woong

doi:10.1186/s13223-021-00590-x

Cited by 19 publications

(21 citation statements)

References 30 publications

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“…They found that patients with severe AD had a significant association with ischemic stroke, although misclassification of AD severity was present. By contrast, the Korean study by Jung et al (2021) using the National Health Insurance Data did not find any association between AD severity with stroke and myocardial infarction. In a Danish nationwide cohort study, Andersen et al (2016) found that patients with mild AD had decreased risk of cardiovascular adverse events.…”

Section: Discussionmentioning

confidence: 63%

“…This study employed a population-based design and a large sample size, but it had a shortcoming of misdiagnosis and lacked controlling for traditional risk factors such as diabetes, alcohol use, and cigarette smoking. Another Asian study using the Korean National Health Insurance Data demonstrated that AD cases had elevated stroke and myocardial infarction risk than those without AD, but there were no adjustments for covariates such as cigarette smoking and hypertension ( Jung et al, 2021 ). In addition to these Asian studies, some epidemiology data from other populations also showed positive associations of AD with ischemic stroke and coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, in the National Health and Nutrition Examination Survey (2005–2006) and the National Health Interview Survey (2010–2012), AD was found to be linked with coronary heart disease and stroke ( Silverberg, 2015 ). In addition, an Asian study using the Korean National Health Insurance data also found that patients with AD were associated with a higher risk of myocardial infarction [hazard ratio (HR) = 9.43, p < 0.001] and stroke (HR = 10.61, p < 0.001) ( Jung et al, 2021 ). However, positive associations were not found in German and Canadian cohorts and a large-scale meta-analysis ( Drucker et al, 2017 ; Standl et al, 2017 ; Thyssen et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study

Huang

Ying

et al. 2022

Front. Genet.

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Background: Atopic dermatitis (AD) is the most common chronic skin inflammatory disease. Prior observational studies have reported inconsistent results on the association of AD with ischemic stroke and coronary heart disease. In this study, we applied two-sample Mendelian randomization (MR) to evaluate the causal effect of AD on ischemic stroke and coronary heart disease.Methods: Twelve single-nucleotide polymorphisms robustly associated with AD (p < 5 × 10–8) were obtained from a genome-wide association study that included 10,788 cases and 30,047 controls by the EArly Genetics and Life course Epidemiology (EAGLE) Consortium (excluding the 23andMe study). The corresponding data for ischemic stroke (34,217 cases and 406,111 controls), large artery stroke (4,373 cases and 406,111 controls), cardioembolic stroke (7,193 cases and 406,111 controls), small vessel stroke (5,386 cases and 192,662 controls), coronary heart disease (122,733 cases and 424,528 controls), and myocardial infarction (43,676 cases and 128,199 controls) were obtained from the MR-Base platform. In the primary MR analyses, we applied the inverse variance weighted method to evaluate the associations. We performed a sensitivity analysis using weighted median, MR-Egger, weighted mode, simple mode, Mendelian Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out methods.Results: In the primary MR analyses, we found no causal association of genetically predicted AD with ischemic stroke [odds ratio (OR) = 1.00, 95% confidence interval (CI): 0.95–1.06], large artery stroke (OR = 1.02, 95% CI: 0.88–1.17), cardioembolic stroke (OR = 1.06, 95% CI: 0.94–1.18), small vessel stroke (OR = 1.05, 95% CI: 0.94–1.17), coronary heart disease (OR = 1.00, 95% CI: 0.94–1.05), and myocardial infarction (OR = 1.03, 95% CI: 0.98–1.09). The results from the primary MR analyses were supported in sensitivity analyses using the weighted median, weighted mode, simple mode, and MR-Egger methods and multivariable MR analyses adjusting for asthma and several traditional risk factors for ischemic stroke and coronary heart disease. MR-Egger intercepts provided no evidence of directional pleiotropy. The MR-PRESSO and leave-one-out analyses did not indicate any outlier instruments.Conclusion: Our MR study does not support a causal association of genetically predicted AD with ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke, coronary heart disease, and myocardial infarction.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study

Huang

Ying

et al. 2022

Front. Genet.

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“…Recent evidence indicates that AD is not only a dermatological disease but also an inflammatory disease that extends beyond the skin. Patients with AD have a greater risk of cardiovascular disorders than healthy controls, including stroke, myocardial infarction, angina, and peripheral vascular disease [ 32 ].…”

Section: Overview Of Ad and Treatment Optionsmentioning

confidence: 99%

Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence

Cho

Kim

Woo

et al. 2022

JCM

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Background: Atopic dermatitis (AD) is an inflammatory skin disease of multiple phenotypes and endotypes, and is highly prevalent in children. Many people of all ages, including active adolescents, pregnant women, and the elderly, suffer from AD, experiencing chronicity, flares, and unexpected relapse. Dexpanthenol has multiple pharmacological effects and has been employed to treat various skin disorders such as AD. We aimed to summarize the up-to-date evidence relating to dexpanthenol and to provide a consensus on how to use dexpanthenol effectively for the treatment of AD. Methods: The evidence to date on the application and efficacy of dexpanthenol in AD was reviewed. The literature search focused on dexpanthenol use and the improvement of skin barrier function, the prevention of acute flares, and its topical corticosteroid (TCS) sparing effects. Evidence and recommendations for special groups such as pregnant women, and the effects of dexpanthenol and emollient plus in maintenance therapy, were also summarized. Results: Dexpanthenol is effective and well-tolerated for the treatment of AD. Dexpanthenol improves skin barrier function, reduces acute and frequent flares, has a significant TCS sparing effect, and enhances wound healing for skin lesions. Conclusion: This review article provides helpful advice for clinicians and patients on the proper maintenance treatment of AD. Dexpanthenol, as an active ingredient in ointments or emollients, is suitable for the treatment and maintenance of AD. This paper will guide dermatologists and clinicians to consider dexpanthenol as a treatment option for mild to moderate AD.

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“…Atopic dermatitis (AD) in children increases the risk of food allergies, asthma, allergic rhinitis, and other immune-mediated inflammatory diseases, as well as mental health disorders, and impairs not only the patients’ but also their family members’ quality of life. 1 2 3 4 …”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity

et al. 2022

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Background Atopic dermatitis (AD) is a heterogeneous disease with different age of onset, disease course, clinical symptoms, severity, and risk of comorbidity. The characteristics of children with AD also vary by age or country. However, little is known about the clinical characteristics of AD in Korean school-aged children and adolescents. Furthermore, there are few studies on phenotypic differences according to onset age. This study aimed to explore the clinical characteristics and phenotypes according to onset age and severity of AD in children and adolescents in Korea. Methods AD patients aged 6–18 years who presented to 18 hospitals nationwide were surveyed. The patients were examined for disease severity by pediatric allergy specialists, and data on history of other allergic diseases, familial allergy history, onset age, trigger factors, lesion sites, treatment history and quality of life were collected. The results of the patient’s allergy test were also analyzed. The patients were classified into infancy-onset (< 2 years of age), preschool-onset (2–5 years of age), and childhood-onset (≥ 6 years of age) groups. Study population was analyzed for clinical features according to onset-age groups and severity groups. Results A total of 258 patients with a mean age of 10.62 ± 3.18 years were included in the study. Infancy-onset group accounted for about 60% of all patients and presented significantly more other allergic diseases, such as allergic rhinitis and asthma ( P = 0.002 and P = 0.001, respectively). Food allergy symptoms and diagnoses were highly relevant to both earlier onset and more severe group. Inhalant allergen sensitization was significantly associated with both infancy-onset group and severe group ( P = 0.012 and P = 0.024, respectively). A family history of food allergies was significantly associated with infancy-onset group ( P = 0.036). Severe group was significantly associated with a family history of AD, especially a paternal history of AD ( P = 0.048 and P = 0.004, respectively). Facial (periorbital, ear, and cheek) lesions, periauricular fissures, hand/foot eczema, and xerosis were associated with infancy-onset group. The earlier the onset of AD, the poorer the quality of life ( P = 0.038). Systemic immunosuppressants were used in only 9.6% of the patients in the severe group. Conclusion This study analyzed the clinical features of AD in Korean children and adolescents through a multicenter nationwide study and demonstrated the phenotypic differences according to onset age and severity. Considering the findings that the early-onset group is more severe and accompanied by more systemic allergic diseases, early management should be emphasized in young children and infants. ...

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Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea

Cited by 19 publications

References 30 publications

Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study

Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study

Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence

Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity

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