Cardiovascular complications of anorexia nervosa: A systematic review

Sachs, Katherine; Harnke, Ben; Mehler, Philip S.; Krantz, Mori J.

doi:10.1002/eat.22481

Cited by 186 publications

(202 citation statements)

References 72 publications

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“…These findings may explain the increased risk of vascular disease among patients with AN. In fact, these results are in agreement with recent studies which suggest that adverse myocardial structural changes occur in AN [61].…”

Section: Involvement Of Leucocyte/endothelial Cell Interactions In Ansupporting

confidence: 93%

Research update for articles published in EJCI in 2015

et al. 2017

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Section: Involvement Of Leucocyte/endothelial Cell Interactions In Ansupporting

confidence: 93%

Research update for articles published in EJCI in 2015

et al. 2017

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“…Together with decreased fat mass, decreased blood pressure and heart rate are typical responses after a diet, even for normotensive and non-overweight individuals (Keys et al, 1950; Awazu et al, 2000; Rossow et al, 2013) showing that the autonomic nervous system also adapts to an energy deficit as expected and, thus, may not be a health risk at these levels of heart rate of ≥49 bpm in all females. However, when the heart rate is more substantially decreased and long lasting such as in anorectic individuals without supervised and controlled refeeding, this can lead to a long QT in ECG and an increased risk for arrhytmia (Sachs et al, 2016). …”

Section: Discussionmentioning

confidence: 99%

The Effects of Intensive Weight Reduction on Body Composition and Serum Hormones in Female Fitness Competitors

et al. 2017

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Worries about the potential negative consequences of popular fat loss regimens for aesthetic purposes in normal weight females have been surfacing in the media. However, longitudinal studies investigating these kinds of diets are lacking. The purpose of the present study was to investigate the effects of a 4-month fat-loss diet in normal weight females competing in fitness-sport. In total 50 participants finished the study with 27 females (27.2 ± 4.1 years) dieting for a competition and 23 (27.7 ± 3.7 years) acting as weight-stable controls. The energy deficit of the diet group was achieved by reducing carbohydrate intake and increasing aerobic exercise while maintaining a high level of protein intake and resistance training in addition to moderate fat intake. The diet led to a ~12% decrease in body weight (P < 0.001) and a ~35–50% decrease in fat mass (DXA, bioimpedance, skinfolds, P < 0.001) whereas the control group maintained their body and fat mass (diet × group interaction P < 0.001). A small decrease in lean mass (bioimpedance and skinfolds) and in vastus lateralis muscle cross-sectional area (ultrasound) were observed in diet (P < 0.05), whereas other results were unaltered (DXA: lean mass, ultrasound: triceps brachii thickness). The hormonal system was altered during the diet with decreased serum concentrations of leptin, triiodothyronine (T3), testosterone (P < 0.001), and estradiol (P < 0.01) coinciding with an increased incidence of menstrual irregularities (P < 0.05). Body weight and all hormones except T3 and testosterone returned to baseline during a 3–4 month recovery period including increased energy intake and decreased levels aerobic exercise. This study shows for the first time that most of the hormonal changes after a 35–50% decrease in body fat in previously normal-weight females can recover within 3–4 months of increased energy intake.

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“…If effective predictions of the likelihood of ventricular fibrillation can be made, advance prevention will reduce the mortality of patients with epilepsy. Ventricular fibrillation is more often induced by cardiac electrical repolarization abnormalities [8], and heart rate variability, Q-T dispersion, T wave alternans [9] in 12 lead ECG can be used to directly observe the cardiac electrical repolarization abnormalities. While heart rate variability needs dynamic ECG monitoring which takes longer, Q-T dispersion and T wave alternating, conventional ECG is able to interpret; so we choose two parameters on RECG, T wave electric alternating and Q-T dispersion, as the observation index.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Q-T Dispersion and T Wave Alternans in Patients with Epilepsy

Shan¹,

Cheng²

2017

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Objectives: There is a high rate of sudden death in epilepsy patients, part of which is sudden cardiac death. By investigating ECG T wave alternans and Q-T dispersion changes of epilepsy patients, we may predict the possibility of the occurrence of sudden death and provide basis for clinical prevention. Methods: Selecting 587 cases of epilepsy patients as the study group, 672 same period cases of healthy persons as the control group; Analyzing the effect of epilepsy on ECG T wave alternans and Q-T dispersion with the standard 12 lead ECG. Results: The study group had a significantly prolonged Q-T dispersion and an increased incidence of T wave alternans than that of the control group; Compared with other seizure types, tonic clonic seizure and absence seizure had a significantly prolonged Q-T dispersion and an increased occurrence rate of T wave alternans. Conclusions: Epilepsy patients ECG T wave alternans and Q-T dispersion has higher abnormal rate, and are prone to sudden cardiac death; Routine ECG(RECG) T wave alternans and Q-T dispersion changes can provide guidance for clinical prevention of sudden unexpected death in epilepsy (SUDEP).

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Cardiovascular complications of anorexia nervosa: A systematic review

Cited by 186 publications

References 72 publications

Research update for articles published in EJCI in 2015

Research update for articles published in EJCI in 2015

The Effects of Intensive Weight Reduction on Body Composition and Serum Hormones in Female Fitness Competitors

Analysis of the Q-T Dispersion and T Wave Alternans in Patients with Epilepsy

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