Cardiovascular Complications of COVID-19: A Scoping Review of Evidence

Ntchana, Armand; Shrestha, Sanjay; Pippin, Micah

doi:10.7759/cureus.48275

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Besides respiratory system injury, cardiac complications such as myocardial injury and heart failure are also common in patients with COVID-19 infection ( Brogi et al, 2022 ; Xie et al, 2022 ; Ntchana et al, 2023 ). It is conceivable that since ECM molecules are important components of myocardial cells and myocardial interstitium for maintaining heart structure, facilitating force transmission between myocardium, and ensuring myocardial contractility ( Dupuy et al, 2019 ), increased levels of ECM molecules are associated with the progression of myocardial fibrosis, heart failure, and acute myocardial infarction ( Wellens, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

Yu,

Yin,

Lei

et al. 2024

Front. Cell Dev. Biol.

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COVID-19 patients often suffer from post-COVID-19 acute sequelae (PASC). Pulmonary fibrosis has the most significant long-term impact on the respiratory health of patients, known as post-COVID-19 pulmonary fibrosis (PC19-PF). PC19-PF can be caused by acute respiratory distress syndrome (ARDS) or COVID-19-induced pneumonia. Individuals who experience COVID-19 pneumonia symptoms (including cough, shortness of breath, dyspnea on exertion, and desaturation) for at least 12 weeks after diagnosis, almost all develop PC19-PF. Extracellular matrix molecules: laminin (LN), type IV collagen (IV Col), procollagen III N-terminal peptide (PIIINP), and hyaluronic acid (HA) are involved in the development and progression of PC19-PF. This study aimed to investigate the relationship between the progression of PC19-PF and serum levels of laminin, IV COL, PIIINP, and hyaluronic acid. This retrospective study included 162 PC19-PF patients treated and 160 healthy controls who received treatment at Shenzhen Longgang District Third People’s Hospital, Hebei PetroChina Central Hospital and Changzhi People’s Hospital from January 2021 to December 2023. Serum levels of LN, IV COL, PIIINP, and HA were detected by chemiluminescence immunoassay using commercial kits. Predicted forced vital capacity percentage (FVC% pred), predicted carbon monoxide lung diffusion capacity percentage (DLCO% pred), high-resolution computed tomography (HRCT) scores were assessed, and patient mortality was compared with healthy controls. Serum levels of LN, IV Col, PIIINP, and HA were significantly higher in PC19-PF or CTD-ILD patients than in healthy controls (all p < 0.05), and they were further elevated in acute exacerbation cases (all p < 0.01). In patients, HA was positively associated with HRCT scores and negatively associated with FVC% pred and DLCO% pred (all p < 0.05). Serum levels of LN, IV COL, PIIINP, and HA were significantly lower in surviving patients than in those who deceased (all p > 0.05). Serum levels of LN, IV C, PIIINP, and HA may affect the progression of PC19-PF and may serve as indicators of PC19-PF severity.

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Section: Discussionmentioning

confidence: 99%

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

Yu,

Yin,

Lei

et al. 2024

Front. Cell Dev. Biol.

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“…РФ -Российская Федерация, СКС -стандартизованный коэффициент смертности. [12]. На это косвенно указывают результаты настоящего исследования.…”

Section: таблицаunclassified

Regional variability of male and female mortality from three types of coronary artery disease: comparison of two periods 2017-2019 and 2020-2022

Samorodskaya,

Klyuchnikov,

Shepel

et al. 2024

Cardiovasc Ther Prev

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Aim. To assess regional variability of standardized mortality rates (SMRs) for men and women from three types of coronary artery disease (CAD) for 2 periods (2017-2019 and 2020-2022).Material and methods. Rosstat data on the average annual population and the number of deaths in one-year age groups for 82 constituent Russian entities were used. SMRs was calculated using software (state registration number 216661114) and the European Standard Population by the direct standardization per 100 thousand population. The average regional SMRs were calculated for 2017-2019 and 20202022 as follows: (I21-I22) myocardial infarction (MI); (I20, I24.1-9) other acute coronary artery disease types; (I25.0-9) chronic coronary syndromes; all 3 groups of CAD.Results. We found that the regional average CAD SMR among men (343,0±98,3 and 364,2±105,7 per 100 thousand population) is >2 times than among women (163,3±55,7 and 179, 5±61,2 per 100 thousand population), but men and women did not differ in the average regional proportion of CAD in the structure of all-cause mortality. In 5 regions, a simultaneous decrease in SMR from three CAD types and their total indicator was registered in both men and women; in 8, an increase in SMR was registered for each of the three forms and their sum, and in the remaining regions, multidirectional dynamics were noted. The coefficient of variation of regional MI SMR changes for men was 830%, for women — 322%; for other acute CAD — 7145% and 2523%, respectively. In general, the increase in CAD SMR occurred mainly due to an increase in SMR from chronic CAD against the background of a decrease in MI SMR. The proportion of chronic CAD in the structure of all CAD types is higher in women (80,1±11,9 and 82,9±10,3%) than in men (75,5±14 and 77,6±13%). The proportion of MI among men is 14,8±6,1 and 13,5±6,6%, among women — 7,1±10,9 and 6,2±8,7%.Conclusion. The pronounced variability of regional SMRs and their changes over time, differences in mortality structure between men and women indicate a number of unresolved statistical issues related to determining the initial cause of death from CAD and its individual types, including with multimorbid pathology.

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Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Liu,

Huang,

Sun

et al. 2024

Preprint

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Introduction Previous studies suggest a potential link between COVID-19 and cardiovascular diseases, particularly heart failure (HF), but causal relationships remain unclear. This study uses bidirectional Mendelian randomization (MR) to investigate these associations.Materials and methods We selected genome-wide association study (GWAS) datasets detailing COVID-19 phenotypes as exposures, while traits associated with HF and its risk factors constituted the outcomes. Our primary estimation method involved utilizing the inverse-variance weighted technique for it could provide a precise estimation by giving more weight to studies with less variance. Alongside, we deployed the weighted median, MR-Egger, MR-PRESSO global test, and Cochran’s Q statistic to address biases, detect and correct for pleiotropy, and assess heterogeneity. Furthermore, we conducted bidirectional MR analysis to ascertain the directional causality.Results Based on the bidirectional MR analysis, our findings indicate a higher likelihood of developing into HF among hospitalized COVID-19 patients, as well as an increased propensity for HF development in individuals with all COVID-19 patients. Furthermore, the presence of HF increases the prevalence of COVID-19, escalates the severity of COVID-19, and raises the hospitalization rate in those affected by COVID-19. COVID-19 does not directly escalate the incidence of the risk factors of HF, but type 2 diabetes mellitus (T2DM) could increases the hospitalization and severity rates of COVID-19 patients. Meanwhile, chronic kidney disease (CKD) contributes to increased hospitalization rates among COVID-19 patients.Conclusion This study provides evidence of a bidirectional causal link among COVID-19 and HF and its risk factors. These findings suggest clinical implications for early detection and management of HF in COVID-19 patients and highlight the need for targeted healthcare resources.

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Cardiovascular Complications of COVID-19: A Scoping Review of Evidence

Cited by 3 publications

References 51 publications

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

The correlation between serum levels of laminin, type IV collagen, type III procollagen N-terminal peptide and hyaluronic acid with the progression of post-COVID-19 pulmonary fibrosis

Regional variability of male and female mortality from three types of coronary artery disease: comparison of two periods 2017-2019 and 2020-2022

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

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