Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis

Saroufim, Paola; Zweig, Sophia Alison; Conway, Devon; Briggs, Farren

doi:10.1016/j.msard.2018.07.011

Cited by 25 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study has reported that hypertension was the most prevalent comorbidity in NMO and the prevalence of hypertension among highly active NMO cases was almost three times higher versus those in matched controls (Ajmera, Boscoe, Mauskopf, Candrilli, & Levy, ). Another study showed no differences in the prevalence of hypertension between NMOSD compared to control participants, while it was 30%–50% higher in MS participants compared to the controls (Saroufim, Zweig, Conway, & Briggs, ). However, no studies to date examined the BP including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP) in patients with neuromyelitis optica spectrum disorder (NMOSD).…”

Section: Introductionmentioning

confidence: 96%

Blood pressure and body fat percent in women with NMOSD

et al. 2019

View full text Add to dashboard Cite

Background Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra‐Body Adiposity Estimator (CUN‐BAE) in NMOSD has not been investigated thus far. Methods Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age‐ and sex‐matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined. Results Comparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110–12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = −0.522, p = 0.004). Conclusions Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.

show abstract

Section: Introductionmentioning

confidence: 96%

Blood pressure and body fat percent in women with NMOSD

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Recent studies suggest an increased risk of cardiovascular events in patients with MS. 7 , 18 – 24 Although the literature is still incomplete and partially contradictory, some larger population-based studies suggest that MS patients have a higher prevalence of cardiovascular diseases (CVD) and a slightly increased CVD mortality risk. 18 , 19 , 22 , 25 In addition, a recent Swedish cohort study found that venous thromboembolic disorders in progressive MS accounted for a substantial proportion of this risk.…”

Section: Introductionmentioning

confidence: 99%

Non-infectious comorbidity in patients with multiple sclerosis: A national cohort study in Sweden

Castelo-Branco¹,

Chiesa²,

Bengtsson³

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

View full text Add to dashboard Cite

Background Comorbidity is of significant concern in multiple sclerosis (MS). Few population-based studies have reported conditions occurring in MS after diagnosis, especially in contemporary cohorts. Objective To explore incident comorbidity, mortality and hospitalizations in MS, stratified by age and sex. Methods In a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years) and 61,828 matched MS-free individuals were identified between 1 January 2008 and 31 December 2016, using national registers. Incidence rates (IRs) and incidence rate ratios (IRRs) with 95% CI were calculated for each outcome. Results IRs of cardiovascular disease (CVD) were higher among MS patients than MS-free individuals, (major adverse CVD: IRR 1.42; 95% CI 1.12–1.82; hemorrhagic/ischemic stroke: 1.46; 1.05–2.02; transient ischemic attack: 1.65; 1.09–2.50; heart failure: 1.55; 1.15–2.10); venous thromboembolism: 1.42; 1.14–1.77). MS patients also had higher risks of several non-CVDs such as autoimmune conditions (IRR 3.83; 3.01–4.87), bowel dysfunction (2.16; 1.86–2.50), depression (2.38; 2.11–2.68), and fractures (1.32; 1.19–1.47), as well as being hospitalized and to suffer from CVD-related deaths ((1.91; 1.00–3.65), particularly in females (3.57; 1.58–8.06)). Conclusion MS-patients experience a notable comorbidity burden which emphasizes the need for integrated disease management in order to improve patient care and long-term outcomes of MS.

show abstract

“…The highest estimate of 47.8% was derived from self‐reports in male veterans with MS [15]. Recent self‐reported and administrative‐claims studies reported estimates closer to 15%, although a 2014 estimate for 30 000 PwMS captured in the IMS Health Real World Data Adjudicated Claims (PharMetrics Plus) US database was 27% [16–18]. Two studies reported an HTN prevalence of 17% to 18% in PwMS based on individual medical records extracted between 2008 and 2012 for 404 and 2083 MS patients, respectively [8,19].…”

Section: Introductionmentioning

confidence: 99%

“…Administrative‐claims data studies have reported conflicting findings on the burden of HTN in females compared to males with MS [17,18]. Furthermore, few studies have investigated the prevalence of HTN in MS populations compared to non‐MS populations; of those that did, some found that HTN was more common in the MS population [15,16,20–22], whereas others found that HTN was less common in the MS population [23–26].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of hypertension in multiple sclerosis based on 37 million electronic health records from the United States

Briggs

Hill²,

Abboud

2020

Euro J of Neurology

Self Cite

View full text Add to dashboard Cite

Background and purposeHypertension (HTN) is a common comorbidity in multiple sclerosis (MS), and it significantly contributes to adverse outcomes. Unfortunately, the distribution of HTN in persons with MS has not been well characterized, and prior estimates have primarily relied on modest sample sizes. The objective of this study was to robustly describe the distribution of HTN in the MS population in comparison to the non‐MS population with considerations for age, sex, and race. To date, this is the largest investigation of its kind.MethodsWe conducted a cross‐sectional study of 37 million unique electronic health records available in the IBM Explorys Enterprise Performance Management: Explore database (Explorys) spanning the United States. This resource has previously been validated for use in MS. We evaluated the prevalence of HTN in MS (N = 122 660) and non‐MS (N = 37 075 350) cohorts, stratifying by age, sex, and race.ResultsThe prevalence of HTN was significantly greater among those with MS than among those without MS across age, sex, and race subpopulations, even after adjusting for age and sex. HTN was 25% more common in MS. In both MS and non‐MS cohorts, the prevalence of HTN progressively increased with age and was higher in Black Americans and in males.DiscussionThis study demonstrated that HTN is significantly more common in the MS population compared to the non‐MS population, irrespective of sex and race. Because HTN is the leading global risk factor for disability and death, these results emphasize the need for aggressive screening for, and management of, HTN in the MS population.

show abstract

Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis

Cited by 25 publications

References 23 publications

Blood pressure and body fat percent in women with NMOSD

Blood pressure and body fat percent in women with NMOSD

Non-infectious comorbidity in patients with multiple sclerosis: A national cohort study in Sweden

The prevalence of hypertension in multiple sclerosis based on 37 million electronic health records from the United States

Contact Info

Product

Resources

About