Cardiovascular Consequences of Preterm Birth in the First Year of Life

Fyfe, Karinna; Yiallourou, Stephanie; Horne, Rosemary Sylvia Claire

doi:10.5772/26252

Cited by 3 publications

(3 citation statements)

References 112 publications

(126 reference statements)

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“…The immaturity of CVS and its control as one of the most vitally important physiological systems can be potentially risky for a premature newborn ( 4 ). Although an information on the maturation related changes in heart rate and heart rate variability reflecting heart rate control by autonomic nervous system are well-know ( 5 , 6 ), the data focusing on another aspects of cardiovascular control – short-term blood pressure variability (BPV) and baroreflex sensitivity (BRS) – are still very rare.…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure Variability and Baroreflex Sensitivity in Premature Newborns—An Effect of Postconceptional and Gestational Age

Javorka

Hašková²,

Czippelová

et al. 2021

Front. Pediatr.

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Introduction: Cardiovascular system is the vitally important system in the dynamical adaptation process of the newborns to the extrauterine environment. To reliably detect immaturity in the given organ system, it is crucial to study the development of the organ functions in relation to maturation process.Objectives: The objective was to determine the changes in the spontaneous short-term blood pressure variability (BPV) and baroreflex sensitivity (BRS) reflecting various aspects of cardiovascular control during the process of maturation in preterm babies and to separate effects of gestational age and postnatal age.Methods: Thirty-three prematurely born infants without any signs of cardio-respiratory disorders (gestational age: 31.8, range: 27–36 weeks; birth weight: 1,704, range: 820–2,730 grams) were enrolled. Continuous peripheral blood pressure signal was obtained by non-invasive volume-clamp photoplethysmography method during supine rest. The recordings of 250 continuous beat-to-beat blood pressure values were processed by spectral analysis of BPV (assessed measures: total power, low frequency and high frequency powers of systolic BPV) and BRS calculation. For each infant we also assessed systolic, diastolic and mean blood pressures, heart rate and respiratory rate.Results: With the postconceptional age, BPV measures decreased (for total power: Spearman correlation coefficient rs = −0.345, P = 0.049; for low frequency power: rs = −0.365, P = 0.037; for high frequency power rs = −0.349; P = 0.046); and BRS increased significantly (rs = 0.448, P = 0.009). The further analysis demonstrated that these effects were more attributable to gestational age than to postnatal age. BRS correlated negatively with BPV magnitude (rs = −0.479 to −0.592, P = 0.001–0.005). Mean blood pressure and diastolic blood pressure increased during maturation (rs = 0.517 and 0.537, P = 0.002 and 0.001, respectively) while heart rate and respiratory rate decreased (rs = −0.366 and −0.516, P = 0.036 and 0.002, respectively).Conclusion: We conclude that maturation process is accompanied by an increased involvement of baroreflex buffering of spontaneous short-term blood pressure oscillations. Gestational age plays a dominant role not only in BPV changes but also in BRS, mean blood pressure, diastolic blood pressure and heart rate changes.

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Section: Introductionmentioning

confidence: 99%

Blood Pressure Variability and Baroreflex Sensitivity in Premature Newborns—An Effect of Postconceptional and Gestational Age

Javorka

Hašková²,

Czippelová

et al. 2021

Front. Pediatr.

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“…Previous studies have suggested that the cut off for parameters is based on clinical 483 intuition and/or historical data rather than on rigorously gathered data (Cuthbertson & Smith, 2007). The 484 effect of gestational age on physiologic parameters, for example, variations in heart rate between gestational 485 age groups has been documented (Fyfe, Yiallourou & Horne, 2012;Van Kuiken & Huth, 2013). 486…”

Section: Physiological Reference Ranges 470mentioning

confidence: 99%

“…Lack of control due to immaturity is demonstrated inA c c e p t e d M a n u s c r i p t the late preterm neonate by their exhibiting a higher resting heart rate (Fyfe, Yiallourou & Horne, 2012). On 491 the other hand, post term neonates can exhibit a lower base line heart rate (Fyfe, Yiallourou & Horne, 2012). 492…”

Section: Heart Rate 488mentioning

confidence: 99%

Neonatal Early Warning Tools for recognising and responding to clinical deterioration in neonates cared for in the maternity setting: A retrospective case–control study

Paliwoda

New

Bogossian

2016

International Journal of Nursing Studies

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Please cite this article as: Paliwoda, M., New, K., Bogossian, F.,Neonatal Early Warning Tools for recognising and responding to clinical deterioration in neonates cared for in the maternity setting: a retrospective case control study, International Journal of Nursing Studies (2016), http://dx.doi.org/10. 1016/j.ijnurstu.2016.06.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Automated Medical Care: Bradycardia Detection and Cardiac Monitoring of Preterm Infants

et al. 2021

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Background and Objectives: Prematurity of birth occurs before the 37th week of gestation and affects up to 10% of births worldwide. It is correlated with critical outcomes; therefore, constant monitoring in neonatal intensive care units or home environments is required. The aim of this work was to develop solutions for remote neonatal intensive supervision systems, which should assist medical diagnosis of premature infants and raise alarm at cardiac abnormalities, such as bradycardia. Additionally, the COVID-19 pandemic has put a worldwide stress upon the medical staff and the management of healthcare units. Materials and Methods: A traditional medical diagnosing scheme was set up, implemented with the aid of powerful mathematical operators. The algorithm was tailored to the infants’ personal ECG characteristics and was tested on real ECG data from the publicly available PhysioNet database “Preterm Infant Cardio-Respiratory Signals Database”. Different processing problems were solved: noise filtering, baseline drift removal, event detection and compression of medical data using the à trous wavelet transform. Results: In all 10 available clinical cases, the bradycardia events annotated by the physicians were correctly detected using the RR intervals. Compressing the ECG signals for remote transmission, we obtained compression ratios (CR) varying from 1.72 to 7.42, with the median CR value around 3. Conclusions: We noticed that a significant amount of noise can be added to a signal while monitoring using standard clinical sensors. We tried to offer solutions for these technical problems. Recent studies have shown that persons infected with the COVID-19 disease are frequently reported to develop cardiovascular symptoms and cardiac arrhythmias. An automatic surveillance system (both for neonates and adults) has a practical medical application. The proposed algorithm is personalized, no fixed reference value being applied, and the algorithm follows the neonate’s cardiac rhythm changes. The performance depends on the characteristics of the input ECG. The signal-to-noise ratio of the processed ECG was improved, with a value of up to 10 dB.

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Cardiovascular Consequences of Preterm Birth in the First Year of Life

Cited by 3 publications

References 112 publications

Blood Pressure Variability and Baroreflex Sensitivity in Premature Newborns—An Effect of Postconceptional and Gestational Age

Blood Pressure Variability and Baroreflex Sensitivity in Premature Newborns—An Effect of Postconceptional and Gestational Age

Neonatal Early Warning Tools for recognising and responding to clinical deterioration in neonates cared for in the maternity setting: A retrospective case–control study

Automated Medical Care: Bradycardia Detection and Cardiac Monitoring of Preterm Infants

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