Cardiovascular Damage in Patients With a New Coronavirus Infection: Current State of the Problem

Kozik, V.A.; Shpagin, I.S.; Шпагина, Л. А.; Локтин, Е. М.

doi:10.17513/spno.32651

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Последнее десятилетие активное развитие получили различные методы рентген-эндоваскулярной хирургии, схемы медикаментозного лечения, но несмотря на это, смертность от сердечно-сосудистых заболеваний остается высокой [2]. Новая коронавирусная инфекция (COVID-19) внесла свои коррективы в тяжесть течения заболевания, ведение и лечение упомянутой группы пациентов, что обусловливает актуальность этой проблемы [3]. Сочетание острого коронарного синдрома (ОКС) и перенесённой COVID-19 сформировало новый фенотип заболевания и побудило к поиску новых возможностей предотвращения осложнений у пациентов с этими нозологиями.…”

Section: оценка ассоциации полиморфизма гена асе с острым коронарным ...unclassified

Assessment of the association of ACE gene polymorphism with acute coronary syndrome in patients after a coronavirus disease 2019

Shpagina,

Kozik,

Maksimov

et al. 2023

Russ J Cardiol

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Aim. To evaluate the association of the nucleotide sequence variant rs1799752 (I/D) of the angiotensin-converting enzyme (ACE) gene with acute coronary syndrome (ACS) in patients after a coronavirus disease 2019 (COVID-19).Material and methods. The study included 100 patients (women — 50, men — 50) with ACS and prior COVID-19, verified by a polymerase chain reaction (PCR), hospitalized in the regional vascular center № 7 of the City Clinical Hospital № 2 city of Novosibirsk. The mean age of women and men was 59,5±7,2 years and 53,5±9,3 years, respectively. The diagnosis of ACS was established according to a set of criteria proposed and established by the Russian Society of Cardiology and in accordance with the updated 2020 guidelines. Patients underwent examinations, coronary angiography with stenting, as provided for in the standards of care and guidelines. In patients, the nucleotide sequence variant rs1799752 of the ACE gene was determined using PCR. The comparison group consisted of 200 patients with ACS without COVID-19 (no positive PCR or antibodies). Statistical analysis was carried out using the SPSS 17.0.5 software package.Results. When comparing the frequencies of rs1799752 genotypes of the ACE gene in groups with ACS with COVID-19 and ACS without COVID-19, significant differences were obtained (p=0,013). In the group with ACS and COVID-19, carriage of the heterozygous genotype was less common (p=0,005) and there was an accumulation of carriers of the homozygous DD genotype (1,6 times higher; 26% vs 16%; p=0,044).Conclusion. The nucleotide sequence variant rs1799752 (I/D) of the ACE gene is associated with ACS in patients after COVID-19.

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Section: оценка ассоциации полиморфизма гена асе с острым коронарным ...unclassified

Assessment of the association of ACE gene polymorphism with acute coronary syndrome in patients after a coronavirus disease 2019

Shpagina,

Kozik,

Maksimov

et al. 2023

Russ J Cardiol

View full text Add to dashboard Cite

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Assessment of the association of the rs12329760 polymorphism of the <i>TMPRSS2</i> gene with acute coronary syndrome in patients with new coronavirus infection

Kozik,

Shpagina,

Shpagin

et al. 2024

jour

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Introduction. Cardiovascular diseases (СVD) rank first in terms of morbidity and mortality not only in the Russian Federation but throughout the world. Since the end of 2019 a pandemic of Severe Acute Respiratory Syndrome (SARS) or new coronavirus infection (NCI) has spread throughout the world, which contributed to the development and course of CVD. Therefore, genetic markers began to be considered as factors potentially influencing CVD, its development and severity. Objective: To evaluate the association of the nucleotide sequence variant rs12329760 of the TMPRSS2 gene with acute coronary syndrome in patients who have had a new coronavirus infection.Material and methods. The study included 100 patients (women – 50, men – 50) with ACS and previous NCI, who were selected on the basis of a positive PCR test for the presence of SARS-CoV-2 in the anamnesis, hospitalized at the regional vascular center No. 7 of the City Clinical Hospital No. 2 of the city of Novosibirsk. Women age was 59.5 ± 7.2 years, men age was 53.5 ± 9.3 years. The diagnosis of ACS was established according to a set of criteria proposed and established by the Russian Society of Cardiology and in accordance with the updated clinical recommendations of the Ministry of Health of the Russian Federation of 2020. Patients underwent clinical and instrumental examination, coronary angiography with possible stenting, as provided for in the standards of medical care and clinical guidelines. The nucleotide sequence variant rs12329760 of the TMPSS2 gene was determined in patients using PCR with further analysis of restriction fragment length polymorphism. The comparison group consisted of 200 patients with ACS without previous NCI (no positive PCR test, no positive antibodies).Results. Carriage of CC, СТ, TT, genotype variants of the nucleotide sequence rs12329760 of the TMPSS2 gene are not associated with an increased risk of developing ACS in patients with previous NCI. When comparing the frequencies of the rs12329760 genotypes of the TMPSS2 gene in groups with ACS with NCI and ACS without NCI, no statistically significant differences were obtained. In the group with ACS with NCI, carriage of the homozygous genotype was more common (p = 0.011).Conclusions. Variants of the nucleotide sequence rs12329760 of the TMPSS2 gene are not associated with ACS with previous NCI.

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Cardiovascular Damage in Patients With a New Coronavirus Infection: Current State of the Problem

Cited by 2 publications

References 33 publications

Assessment of the association of ACE gene polymorphism with acute coronary syndrome in patients after a coronavirus disease 2019

Assessment of the association of ACE gene polymorphism with acute coronary syndrome in patients after a coronavirus disease 2019

Assessment of the association of the rs12329760 polymorphism of the <i>TMPRSS2</i> gene with acute coronary syndrome in patients with new coronavirus infection

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