Cardiovascular disease and healthy ageing

Mooney, Kathleen M.; Auley, Mark T. Mc

doi:10.15761/jic.1000122

Cited by 12 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is apparent from our discussion of cholesterol metabolism, that it is an exceptionally complex system with a multitude of interacting mechanisms ( 111 , 112 ) . Many of these mechanisms interact via positive and negative feedback regulators, the dynamics of which is not trivial.…”

Section: Applying Systems Biology To Our Understanding Of Cholesterolmentioning

confidence: 99%

Investigating cholesterol metabolism and ageing using a systems biology approach

et al. 2016

View full text Add to dashboard Cite

CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age respectively in 2011. The dysregulation of cholesterol metabolism with age, often observed as a rise in LDL-cholesterol, has been associated with the pathogenesis of CVD. To compound this problem, it is estimated by 2050, 22 % of the world's population will be over 60 years of age, in culmination with a growing resistance and intolerance to pre-existing cholesterol regulating drugs such as statins. Therefore, it is apparent research into additional therapies for hypercholesterolaemia and CVD prevention is a growing necessity. However, it is also imperative to recognise this complex biological system cannot be studied using a reductionist approach; rather its biological uniqueness necessitates a more integrated methodology, such as that offered by systems biology. In this review, we firstly discuss cholesterol metabolism and how it is affected by diet and the ageing process. Next, we describe therapeutic strategies for hypercholesterolaemia, and finally how the systems biology paradigm can be utilised to investigate how ageing interacts with complex systems such as cholesterol metabolism. We conclude by emphasising the need for nutritionists to work in parallel with the systems biology community, to develop novel approaches to studying cholesterol metabolism and its interaction with ageing.

show abstract

Section: Applying Systems Biology To Our Understanding Of Cholesterolmentioning

confidence: 99%

Investigating cholesterol metabolism and ageing using a systems biology approach

et al. 2016

View full text Add to dashboard Cite

show abstract

“…An example of this decline is the dysregulation of cholesterol metabolism which is inextricably linked to CVD. Therefore, a keen area of focus is how intrinsic aging impacts whole‐body cholesterol metabolism . Recently, we developed a whole‐body model that attempted to capture whole‐body cholesterol metabolism .…”

Section: Approaches To Modeling Agingmentioning

confidence: 99%

Aging and computational systems biology

Mooney

Morgan

Auley

2016

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

Aging research is undergoing a paradigm shift, which has led to new and innovative methods of exploring this complex phenomenon. The systems biology approach endeavors to understand biological systems in a holistic manner, by taking account of intrinsic interactions, while also attempting to account for the impact of external inputs, such as diet. A key technique employed in systems biology is computational modeling, which involves mathematically describing and simulating the dynamics of biological systems. Although a large number of computational models have been developed in recent years, these models have focused on various discrete components of the aging process, and to date no model has succeeded in completely representing the full scope of aging. Combining existing models or developing new models may help to address this need and in so doing could help achieve an improved understanding of the intrinsic mechanisms which underpin aging.

show abstract

“…Rabinowitsch [29] and Mooney [30] introduced the pipe flow characteristic parameter 8v/D. So Equation (8) can be rewritten as g w;n ¼ 8v=ð2=3ÞD hy , so that the shear rate can be put into the same form as the Newtonian pipe flow shear rate.…”

Section: Generalised Annular Flow Indexmentioning

confidence: 99%

A new utility calculation model for axial flow of non‐Newtonian fluid in concentric annuli

et al. 2014

View full text Add to dashboard Cite

A new utility approach that is independent of the rheological model is presented for the flow of non‐Newtonian fluids in concentric annulus. The novel model was developed without assuming that the generalised flow index remains constant over all shear rate ranges. Based on the slot model, the flow rate expressions for all common rheological models flowing in annuli were obtained, such as the Herschel–Bulkley model, the Robertson–Stiff model, and the Four‐parameter model, and they all can be solved numerically to obtain accurate wall shear rate and shear stress. Following Metzner and Reed's study, we defined a generalised flow index for non‐Newtonian fluid flow in annuli. Through a theoretical analysis, we also defined a new effective diameter for non‐Newtonian fluid flow in annuli, which accounts for the effects both of annulus geometry and fluid rheology but which is different from that was proposed by Reed and Pilehvari. Through the generalised effective diameter we linked non‐Newtonian annular flow with Newtonian pipe flow. A general annular Reynolds number expression was derived from this method for conditions under which the generalised flow index is variable. A theoretical calculation method for the generalised flow index and a uniform pressure loss calculation model for non‐Newtonian flow in concentric annuli were developed, which are applicable to all time‐independent non‐Newtonian fluid. The predictions of this model have been compared with an extensive set of data from the literature. The comparisons of different fluids in different size annuli show very good agreement over the entire range of flow types.

show abstract

Cardiovascular disease and healthy ageing

Cited by 12 publications

References 28 publications

Investigating cholesterol metabolism and ageing using a systems biology approach

Investigating cholesterol metabolism and ageing using a systems biology approach

Aging and computational systems biology

A new utility calculation model for axial flow of non‐Newtonian fluid in concentric annuli

Contact Info

Product

Resources

About