Cardiovascular disease and lung cancer

de Jesus, Mikhail; Chanda, Anindita; Grabauskas, Titas; Kumar, Manish; Kim, Agnes S.

doi:10.3389/fonc.2024.1258991

Cited by 7 publications

(1 citation statement)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In LC, estimated to cause 234 580 cases and 125 070 deaths in the United States in 2024, CVD is a leading cause of morbidity and mortality. 2 , 39 While no studies have directly investigated the link between stress and CVD in LC, evidence suggests that stress could contribute to the development of this cancer type. 40 Our work indicates that beyond the development of LC itself, stress may be associated with the development of CVD after LC diagnosis, because a 1‐point increase in AL was linked with up to a 21% increased associated risk of MACE, with HF being the MACE with the highest associated risk (23%).…”

Section: Discussionmentioning

confidence: 99%

Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer

Stabellini,

Cullen,

Bittencourt

et al. 2024

JAHA

View full text Add to dashboard Cite

Background Cardiovascular disease and cancer share a common risk factor: chronic stress/allostatic load (AL). A 1‐point increase in AL is linked to up to a 30% higher risk of major cardiac events (MACE) in patients with prostate cancer. However, AL's role in MACE in breast cancer, lung cancer, or colorectal cancer remains unknown. Methods and Results Patients ≥18 years of age diagnosed with the mentioned 3 cancers of interest (2010–2019) and followed up at a large, hybrid academic‐community practice were included in this retrospective cohort study. AL was modeled as an ordinal measure (0–11). Adjusted Fine–Gray competing risks regressions estimated the impact of AL precancer diagnosis on 2‐year MACE (a composite of heart failure, ischemic stroke, acute coronary syndrome, and atrial fibrillation). The effect of AL changes over time on MACE was calculated via piecewise Cox regression (before, and 2 months, 6 months, and 1 year after cancer diagnosis). Among 16 467 patients, 50.5% had breast cancer, 27.9% had lung cancer, and 21.4% had colorectal cancer. A 1‐point elevation in AL before breast cancer diagnosis corresponded to a 10% heightened associated risk of MACE (adjusted hazard ratio, 1.10 [95% CI, 1.06–1.13]). Similar findings were noted in lung cancer (adjusted hazard ratio, 1.16 [95% CI, 1.12–1.20]) and colorectal cancer (adjusted hazard ratio, 1.13 [95% CI, 1.08–1.19]). When considering AL as a time‐varying exposure, the peak associated MACE risk occurred with a 1‐point AL rise between 6 and 12 months post‐ breast cancer, lung cancer, and colorectal cancer diagnosis. Conclusions AL warrants investigation as a potential marker in these patients to identify those at elevated cardiovascular risk and intervene accordingly.

show abstract

Section: Discussionmentioning

confidence: 99%

Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer

Stabellini,

Cullen,

Bittencourt

et al. 2024

JAHA

View full text Add to dashboard Cite

show abstract

Causes of death and trends in mortality from the year 2000 to 2017 in patients with acute myocardial infarction

Scharlach,

Schmitz,

Raake

et al. 2024

Annals of Medicine

View full text Add to dashboard Cite

Objective To investigate the most common causes of death and trends in cause-specific long-term mortality in patients hospitalized for acute myocardial infarction (AMI). Methods This analysis was based on 10,718 patients, aged 25–74 years, recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. All hospitalized cases of AMI occurring in the study region during this period were included. If a patient died during follow-up (median: 6.6 years, IQR: 2.8–11.2) the death certificate was obtained and coded using the ICD-10 to determine the main cause of death. Cause-specific mortality was calculated for three 6-year periods. Multivariable adjusted Cox regression models stratified by time interval were calculated. Results The most common cause of death was cardiovascular disease (CVD), more precisely ischemic-heart disease (IHD), followed by cancer. The proportions of CVD deaths and IHD deaths were stable over time. An increasing trend was observed in cancer mortality in post-AMI patients. In male patients, the hazard ratio for cancer mortality was 44.4% higher in 2012–2017 compared to 2000–2005, in female patients, it was more than twice as high in 2006–2012 compared to 2000–2005. Conclusion This study revealed consistent CVD and IHD long-term mortality and increasing trends in long-term cancer mortality in patients post-AMI. Thus, post-AMI patients should emphasize tertiary prevention of CVD by minimizing risk factors. Furthermore, patients should regularly undergo cancer screening programs. The reasons for the unfavorable development in terms of increasing cancer mortality should be investigated in further studies.

show abstract

Predicting Prognostic Bidirectional Molecular Signatures Associating Myocardial Infarction and Lung Cancer: AnIn-SilicoPerspective

Nandi,

Janardhanan,

Agrawal

2024

Preprint

View full text Add to dashboard Cite

Myocardial Infarction (MI) and lung cancers substantially contributors to morbidity and mortality. They share common risk factors such as smoking, and hypertension. There is a pressing need to identify bidirectional molecular signatures linking MI and lung cancer relationship to create a unique triage to improve the clinical outcomes of the patient. In the current work, we extracted the common differentially expressed genes (DEGs) between MI and lung cancer and identified 2339 upregulated and 2973 downregulated genes in MI datasets; 952 upregulated and 653 downregulated genes in LUAD; 1466 upregulated and 2816 downregulated genes in LUSC. Among these, 27 genes (11 upregulated and 16 downregulated) were common across MI, LUAD, and LUSC. Functional enrichment analysis revealed shared biological processes, such as inflammatory response, and cell differentiation. KEGG pathway analysis highlighted common pathways such as B cell receptor signaling, TNF signaling. A protein-protein interaction study with STRING revealed a variety of interaction partners; miRNA-mRNA network analysis characterizes conserved binding sites for 6 genes while overall survival analysis for lung cancer patients shows a significant association with prognosis. In addition, machine learning models built using the Support Vector Machine and Random Forest algorithms demonstrated high AUROC values of 0.79 and 0.81 respectively on balanced dataset in the classifying MI patients from non-MI patients. Lastly, based on drug repurposing analysis, we proposed FDA-approved drugs such as Venetoclax, Lomitapide, Regorafenib that could potentially target these genes, indicating novel therapeutic options for the co-occurring conditions of MI and lung cancer. Our findings highlight the similarities in molecular makeup between lung cancer and MI, providing information for future investigations and therapeutic approaches.

show abstract

Cardiovascular disease and lung cancer

Cited by 7 publications

References 81 publications

Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer

Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer

Causes of death and trends in mortality from the year 2000 to 2017 in patients with acute myocardial infarction

Predicting Prognostic Bidirectional Molecular Signatures Associating Myocardial Infarction and Lung Cancer: AnIn-SilicoPerspective

Contact Info

Product

Resources

About