Cardiovascular disease and risk factors in adults with diabetes mellitus in Hungary: a population-based study

Ulambayar, Battamir; Ghanem, Amr Sayed; Kovács, Nóra; Trefán, László; Móré, Marianna; Nagy, Attila Csaba

doi:10.3389/fendo.2023.1263365

Cited by 3 publications

(2 citation statements)

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“…Composite variables were created for CVDs (encompassing stroke, myocardial infarction, arrhythmia, and coronary artery diseases) and cardiovascular risk profile (combining hypertension, CVDs, and hypercholesterolemia) to provide a comprehensive assessment of cardiac health. The main outcomes investigated were binary classifications of these conditions [ 41 ].…”

Section: Methodsmentioning

confidence: 99%

Role of oral health in heart and vascular health: A population-based study

Ghanem,

Németh,

Móré

et al. 2024

PLoS ONE

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Background and aim Conditions such as hypertension, cardiovascular diseases, and hypercholesterolemia, are a major public health challenge. This study investigates the influence of oral health indicators, including gum bleeding, active dental caries, tooth mobility, and tooth loss, on their prevalence in Hungary, considering socioeconomic, demographic, and lifestyle factors. Materials and methods Data from the 2019 Hungarian European Health Interview Survey with 5,603 participants informed this analysis. Data were accessed from the records maintained by the Department of Health Informatics at the University of Debrecen between September and November 2023. Variable selection employed elastic net regularization and k-fold cross-validation, leading to high-performing predictors for weighted multiple logistic regression models. Sensitivity analysis confirmed the findings’ validity. Results Significant links were found between poor oral health and chronic cardiac conditions. Multiple teeth extractions increased hypertension risk (OR = 1.67, 95% CI: [1.01–2.77]); dental prosthetics had an OR of 1.45 [1.20–1.75]. Gum bleeding was associated with higher cardiovascular disease (OR = 1.69 [1.30–2.21]) and hypercholesterolemia risks (OR = 1.40 [1.09–1.81]). Conclusions Oral health improvement may reduce the risk of cardiac conditions. This underscores oral health’s role in multidisciplinary disease management.

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Section: Methodsmentioning

confidence: 99%

Role of oral health in heart and vascular health: A population-based study

Ghanem,

Németh,

Móré

et al. 2024

PLoS ONE

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“…Lifestyle factors like alcohol consumption and smoking were dichotomized as either users or non-users. Body Mass Index (BMI) was classified as either normal (≤24.9) or overweight/obese (≥25) ( 36 ).…”

Section: Methodsmentioning

confidence: 99%

Oral health’s role in diabetes risk: a cross-sectional study with sociodemographic and lifestyle insights

Ghanem,

Nagy

2024

Front. Endocrinol.

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IntroductionDiabetes, a key chronic non-communicable disease, poses a substantial public health burden. The role of oral health as a determinant in the epidemiology of diabetes mellitus, particularly in the Central Eastern European region, remains underexplored. This research aims to examine the impact of specific oral health parameters, including gum bleeding, active dental caries, tooth mobility, and tooth loss, on diabetes prevalence. Additionally, it seeks to clarify the moderating effects of socio-demographic and lifestyle variables on this relationship.Materials and methodsData were extracted from the 2014 and 2019 datasets of the Hungarian European Health Interview Survey, comprising a combined nationally representative sample of 11,429 participants. Descriptive statistics were presented as weighted proportions and unweighted counts, and weighted Pearson’s chi-squared tests were employed for assessing associations and goodness-of-fit. Significant predictors were integrated into weighted multiple logistic regression models for analysis. Sensitivity analysis was then conducted to confirm the robustness of the findings.ResultsThe study identified ‘Bad’ self-perceived oral health as a diabetes risk (OR=1.35; 95% CI: [1.04-1.75]), with filled teeth being protective (0.65 [0.51-0.84]). Subgroup analysis revealed higher diabetes odds among individuals with primary education (1.41 [1.02-1.96]) and rural residents with tooth loss from decay (3.54 [1.36-9.19]). The bootstrap analysis with 1,000 iterations reaffirmed the model’s stability and predictive accuracy for diabetes.DiscussionEnhanced oral health is associated with lower risk factors for diabetes. This research highlights the importance of including oral health measures in comprehensive diabetes management approaches.

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Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications

Xia,

Li,

Bai

et al. 2024

DMSO

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Coenzyme Q has garnered significant attention due to its potential role in enhancing cellular energy production and its antioxidant properties. We delve into the therapeutic potential of coenzyme Q in managing diabetes mellitus and its complications, highlighting its capacity to improve mitochondrial function, reduce inflammation and oxidative stress, and correct lipid profiles. Coenzyme Q has shown promise in ameliorating insulin resistance and alleviating complications such as diabetic peripheral neuropathy, kidney disease, retinopathy, and cardiomyopathy. However, its clinical application is limited by poor bio-availability. This review also provides a comprehensive overview of current therapeutic strategies for diabetes complications involving coenzyme Q, including stimulating endogenous synthesis and utilizing carrier transport systems, offering insights into mechanisms for enhancing coenzyme Q bio-availability. These findings suggest that, with improved delivery methods, coenzyme Q could become a valuable adjunct therapy in the management of diabetes mellitus.

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Cardiovascular disease and risk factors in adults with diabetes mellitus in Hungary: a population-based study

Cited by 3 publications

References 55 publications

Role of oral health in heart and vascular health: A population-based study

Role of oral health in heart and vascular health: A population-based study

Oral health’s role in diabetes risk: a cross-sectional study with sociodemographic and lifestyle insights

Research Progress of Coenzyme Q in Diabetes Mellitus and Its Common Complications

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