Cardiovascular Disease-Associated Skin Conditions

Abstract

According to data from the American Heart Association and the World Health Organization, cardiovascular disease (CVD) is the most frequent cause of premature death. Several inflammatory and non-inflammatory skin diseases have been associated with metabolic syndrome and cardiovascular risk (CVR). Here, we classified these conditions into traditionally CVR-associated and those that have been linked to a lesser degree. Psoriasis and hidradenitis suppurativa are commonly associated with CVD, sharing common inflammatory pathways and a higher prevalence of traditional cardiovascular risk factors. Many other diseases could be associated indirectly -with no common pathogenic features with the atheromatous disease -but share a higher prevalence of standard cardiovascular risk and chronic inflammatory state. This review aims to highlight the associated cardiovascular risk that exists for some dermatologic diseases and sensitize cardiologists, dermatologists, and first care providers to implement risk factor control promptly.

New Markers for Cardiovascular Disease in Psoriatic Patients: Preliminary Study on Monocyte Phenotype, ADAMTS7, and mTOR Activity

“…In psoriasis pathophysiology, Th1 and Th17 pathway activation could be associated with accelerated atheromatosis by multiple mechanisms [ 5 ]; moreover, which modules are involved in specific aspects of vessel wall changes have yet to be fully elucidated [ 5 ]. The mammalian adaptation complex (mTORC) also has an important role in the pathogenesis of the atherosclerosis process.…”

Assessing the Relationship Between Vitiligo and Cardiovascular Disease Risk Factors

“…4 Additionally, patients with vitiligo demonstrated a higher risk for developing atherosclerotic events, dyslipidaemia, and cardiovascular risk. 5 Cardiovascular disease (CVD) is a leading cause of death globally, and is a significant contributor to healthcare expenditure. In 2019, 32% of all deaths worldwide were attributed to CVD, totalling an estimated 18.6 million people.…”

“…Specifically, dermatologic conditions, such as psoriasis and hidradenitis suppurativa, have been linked to increased cardiovascular risk. 5 Other conditions, including vitiligo, have received attention as they may share similar pathophysiologic mechanisms to CVD, and also may be linked to traditional CVD risk factors. 5 To the best of the authors' knowledge, this is the first systematic review that assesses the association between vitiligo and CVD.…”

“…5 Other conditions, including vitiligo, have received attention as they may share similar pathophysiologic mechanisms to CVD, and also may be linked to traditional CVD risk factors. 5 To the best of the authors' knowledge, this is the first systematic review that assesses the association between vitiligo and CVD. Previous research suggests that patients with vitiligo are at a higher risk of developing dyslipidaemia, atherosclerosis, and a potential increase in cardiovascular risk.…”

“…Previous research suggests that patients with vitiligo are at a higher risk of developing dyslipidaemia, atherosclerosis, and a potential increase in cardiovascular risk. 5 Further, a case-control study Key Points 1. Despite being primarily seen as a cosmetic condition, vitiligo has systemic implications which are frequently overlooked.…”