Cardiovascular disease in patients with spondyloarthropathies

Vinsonneau, Ulric; Brondex, A.; Mansourati, Jacques; Saraux, Alain; Cornily, J.-C.; Arlès, Florence; Godon, P; Quiniou, G.

doi:10.1016/j.jbspin.2007.04.011

Cited by 33 publications

(19 citation statements)

References 35 publications

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“…The results of these researches have shown that a variety of cardiovascular problems are directly associated with HLA-B27. Aortic root dilation, aortic valve and mitral valve regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular (AV) node conduction block, and J-wave syndrome are some of these diseases [6,7]. On the other hand, electrophysiologic studies showed that conduction disorders in the AV node are more prevalent in carriers of HLA-B27 [6].…”

Section: Introductionmentioning

confidence: 99%

“…Aortic root dilation, aortic valve and mitral valve regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular (AV) node conduction block, and J-wave syndrome are some of these diseases [6,7]. On the other hand, electrophysiologic studies showed that conduction disorders in the AV node are more prevalent in carriers of HLA-B27 [6]. In the current study we aimed to evaluate the association between the AV node blocks and the presence of HLA-B27 in Iranian patients undergoing permanent pacemaker implantation with regard to lesser prevalence of this antigen in the Iranian society compared with European countries and the United States population [5].…”

Section: Introductionmentioning

confidence: 99%

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Frequency of HLA-B27 in Patients With Conductive System Disturbance and Implanted Permanent Pacemaker in Iran

Sayah

Ebrahimi

Piroozmand

2017

ijcp

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Introduction: HLA-B27 is considered as one of the causes of heart conductive disorders. We studied the frequency of HLA-B27 among Iranian patients who had undergone permanent pacemaker implantation. Methods: This descriptive and analytical study was performed among patients who underwent permanent pacemaker implantation. The questionnaire contains demographic data, underling diseases, and history of heart disease or heart surgery. The type of conductive heart disorder was mentioned there, too. We determined the regurgitation of aorta valve and its severity. Finally, HLA-B27 was accessed.All the data was entered in SPSS software and analyzed. Results: From a total of 103 patients entered in this study, only 6 (5.8%) were HLA-B27-positive. The disturbance of conductive heart disorders based on the HLA-B27 positive or negative patients was not statistically different. Patients with HLA-B27 mostly had regurgitation of the aorta valve. Conclusions: We concluded that the frequency of positive HLA-B27 genotype in patients with permanent pacemakers did not have any significant difference with the ones with negative HLA-B27 genotype. However; this genotype was associated with regurgitation of the aorta valve.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Frequency of HLA-B27 in Patients With Conductive System Disturbance and Implanted Permanent Pacemaker in Iran

Sayah

Ebrahimi

Piroozmand

2017

ijcp

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“…It has been reported that there is an increased cardiovascular mortality in patients with spondyloarthropathies [4]. In fact the first reported case of cardiac involvement in spondyloarthropathy already appeared in 1936 [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…In fact the first reported case of cardiac involvement in spondyloarthropathy already appeared in 1936 [5,6]. Aortic root involvement is echocardiographically detectable in 61 % of patients with ankylosing spondylitis [4,7,8] presenting echocardiograpically as thickening of the posterior aortic wall with occasional aortic root dilation [4,7,8]. Aortic regurgitation is a known complication of HLA-B27 spondyloarthropathy as a result of cusp thickening and aortic root dilation [4,9].…”

Section: Introductionmentioning

confidence: 99%

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HLA-B27 and an Electrocardiographic Peculiarity

Ker¹

2011

J Clinic Experiment Cardiol

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Introduction: An increased cardiovascular mortality has been described in patients with spondyloarthropathies due to HLA-B27. Numerous cardiovascular afflictions are currently known to be associated with HLA-B27. These include aortic root dilation, aortic regurgitation, mitral regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular conduction block and more recently, the presence of J-waves.Materials and methods: 48 HLA-B27 positive patients (23 men and 25 women) were included in this observational study. A 12-lead electrocardiogram and a signal-averaged electrocardiogram was recorded in every patient in order to detect any possible J-waves and ventricular late potentials respectively.Results: 27 out of these 48 patients demonstrated a visible J-wave in the inferolateral leads. It was revealed that there is a likelihood ratio of 11.386 (p=0.00074) to demonstrate a visible J-wave if the duration of low-amplitude signals is less than 30 ms. Conclusion:HLA-B27 positive patients has a high incidence of inferolateral cardiac J-waves. There is a high probability of demonstrating such a J-wave on the 12-lead electrocardiogram if the duration of ventricular late potentials is less than 30 ms. The possible mechanisms of this electrocardiographic paradox is discussed.

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Systemic Autoimmune Disease and Premature Atherosclerosis

Knight¹,

Kaplan²

2014

Encyclopedia of Medical Immunology

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Cardiovascular disease in patients with spondyloarthropathies

Cited by 33 publications

References 35 publications

Frequency of HLA-B27 in Patients With Conductive System Disturbance and Implanted Permanent Pacemaker in Iran

Frequency of HLA-B27 in Patients With Conductive System Disturbance and Implanted Permanent Pacemaker in Iran

HLA-B27 and an Electrocardiographic Peculiarity

Systemic Autoimmune Disease and Premature Atherosclerosis

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