Cardiovascular Disease in Patients With Chronic Kidney Disease

Jaradat, Majd I.; Molitoris, Bruce A.

doi:10.1053/snep.2002.35964

Cited by 27 publications

(14 citation statements)

References 97 publications

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“…It has been reported to be a risk factor for cardiovascular disease and to contribute to diabetes-related cardiovascular complications (Jaradat and Molitoris, 2002). CKD-related hypertension is classified into 2 groups, volume-dependent and volume-independent, based on the response to diuresis or ultrafiltration (Sica and Carl, 2005).…”

Section: Introductionmentioning

confidence: 99%

Indoxyl sulfate induces renin release and apoptosis of kidney mesangial cells

et al. 2014

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-Background: Indoxyl sulfate is considered to play a pathological role in the progression of chronic kidney disease. The aim of this study was to investigate the deleterious effects of indoxyl sulfate on kidney mesangial cells. Materials and Methods: Rat renal mesangial cells were exposed to indoxyl sulfate at a serial concentrations. Cytotoxicity of indoxyl sulfate on renal mesangial cells was determined using MTT assay. Protein levels of cleaved caspase-3, angiotensin, angiotensin converting enzyme (ACE) and renin were detected by immunoblotting. Reverse transcriptional PCR was performed to determine the mRNA expression. Results: Level of cleaved caspase-3 was augmented while the cell viability was inhibited by indoxyl sulfate in a dose-dependent manner. The mRNA expressions of pro-renin and ACE were upregulated in mesangial cells exposed to indoxyl sulfate. Level of renin and ACE was increased in response to indoxyl sulfate exposure in time-dependent fashion. Conclusion: Indoxyl sulfate increased viability and induced cell death of renal mesangial cells, which is time-dependent. The loss of cell viability is attributed to caspase-3 activity through apoptosis pathway. RAS in renal mesangial cells is activated in response to indoxyl sulfate treatment.

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Section: Introductionmentioning

confidence: 99%

Indoxyl sulfate induces renin release and apoptosis of kidney mesangial cells

et al. 2014

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“…[6][7][8][9] We aimed to study the correlation of the inflammatory markers (CRP, fibrinogen, and albumin) as CVD risk factors in patients diagnosed with ESRD who just started to receive CAPD in our medical center.…”

Section: Introductionmentioning

confidence: 99%

Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

et al. 2008

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We aimed to study the relationship between the C-reactive protein (CRP), albumin, and fibrinogen as cardiovascular risk factors in continuous ambulatory peritoneal dialysis (CAPD) patients, in the early stage of their therapy. The study included 21 CAPD patients as the study group (SG) and age-and sexmatched 21 healthy patients as the control group (CG). History and physical exam data were obtained for all cases, and demographic baseline characteristics were taken. Twelve-hour fasting serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, total protein, albumin, hemoglobin, CRP, and fibrinogen were obtained.There was no statistically significant difference between the SG and CG in baseline characteristics, including age, sex, body mass index (BMI), smoking, and family history of cardiovascular disease. However, diabetes mellitus (DM) and hypertension (HTN) were significantly more common among the study group. The average total protein, albumin, and hemoglobin levels were significantly lower, and the CRP and fibrinogen levels were significantly higher (p < 0.001) in the SG. A positive correlation was seen (r = 0.443, p < 0.05) among CRP and fibrinogen levels in SG. There was no correlation among the other parameters in SG. For CG, there was no correlation seen for any studied parameters. When patients with and without cardiovascular disease (CVD) were compared, no correlation was seen between CRP and other parameters. A positive correlation of CRP and fibrinogen levels as cardiovascular risk factors was shown in early stage

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“…Calcium-phosphorus metabolism alterations starting in the early stages of renal insufficiency negatively affects the cardiovascular system [14,15]. Atherosclerosis and coronary artery disease associated with chronic inflammation are the most important risk factors responsible for mortality and morbidity of end-stage kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Relation of calcium phosphorus product with cardiovascular risk and hscrp in hemodialysis patients

Çelebi¹,

Yalcin²,

Böyük³

et al. 2017

AJR

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Abstract:Objective: In extensive studies done on chronic kidney disease (CKD) patients, dysregulated bone mineral metabolism is closely associated with the risk of cardiovascular disease and increased risk of morbidity and mortality is revealed. In this study we examine the relationshi p between calcium phosphorus product which is known to be an independent risk factor in chronic hemodialysis patients and HsCRP values.

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Cardiovascular Disease in Patients With Chronic Kidney Disease

Cited by 27 publications

References 97 publications

Indoxyl sulfate induces renin release and apoptosis of kidney mesangial cells

Indoxyl sulfate induces renin release and apoptosis of kidney mesangial cells

Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

Relation of calcium phosphorus product with cardiovascular risk and hscrp in hemodialysis patients

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