Cardiovascular disease in the masai

Mann, George V.; Shaffer, Roy D.; Anderson, Robert S.; Sandstead, Harold H.; Prendergast, Heather M.; Mann, JimI; Rose, Shahgholiabasi; Powell-Jackson, J. D.; Moitanik, S.; Monah, J. Ol; Isaac, Shaun; Msangi, Onesimo H.; Frank, Elizabeth S.; Martin, Julia; Lane, J. Athene; Rasmussen, I.; Dicks, Kristen V.

doi:10.1016/s0368-1319(64)80041-7

Cited by 160 publications

(43 citation statements)

References 28 publications

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“…The studies described above, which directly addressed the question of structural enlargement of conduit and resistance arteries in response to exercise training, reinforced much earlier case reports or observational evidence that regular exercise enhanced the size of coronary vessels (Currens and White 1961;Mann et al 1964). It is also important to emphasize that the in vivo human experiments presented above, which relate to the impacts of exercise on the vasculature, are strongly supported by animal data.…”

Section: Impacts Of Exercise On Resistance and Conduit Artery Remodelsupporting

confidence: 57%

Effects of Exercise on Vascular Function, Structure, and Health in Humans

Green

Smith

2017

Cold Spring Harb Perspect Med

125

101

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Physical activity has profound impacts on the vasculature in humans. Acute exercise induces immediate changes in artery function, whereas repeated episodic bouts of exercise induce chronic functional adaptation and, ultimately, structural arterial remodeling. The nature of these changes in function and structure are dependent on the characteristics of the training load and may be modulated by other factors such as exercise-induced inflammation and oxidative stress. The clinical implications of these physiological adaptations are profound. Exercise impacts on the development of atherosclerosis and on the incidence of primary and secondary cardiovascular events, including myocardial infarction and stroke. Exercise also plays a role in the amelioration of other chronic diseases that possess a vascular etiology, including diabetes and dementia. The mechanisms responsible for these effects of exercise on the vasculature are both primary and secondary in nature, in that the benefits conferred by changes in cardiovascular risk factors such as lipid profiles and blood pressure occur in concert with direct effects of arterial shear stress and mechanotransduction. From an evolutionary perspective, exercise is an essential stimulus for the maintenance of vascular health: exercise is vascular medicine.

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Section: Impacts Of Exercise On Resistance and Conduit Artery Remodelsupporting

confidence: 57%

Effects of Exercise on Vascular Function, Structure, and Health in Humans

Green

Smith

2017

Cold Spring Harb Perspect Med

125

101

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“…[18][19][20] In accordance, many crosssectional studies of the dietary habits within a population have found no association between cholesterol and the intake of saturated fat. [21][22][23][24][25][26] In the abovementioned low-carbohydrate trials (table 1) a high intake of saturated fat had no adverse effects on other lipids either.…”

Section: National Center Of Public Health Protectionmentioning

confidence: 71%

Outcome of the Public consultation on the Draft Opinion of the Scientific Panel on Dietetic Products, Nutrition, and Allergies (NDA) on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol

2010

EFS2

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“…These are not really clinical trials but are studies where researchers lived with peoples or tribes who were still eating traditional diets. In the studies of Stefansson (1969), Shaper (1962), Mann, Shaffer and Anderson (1964), Mann et al (1972), McGarrison (1936), Hrdlička (1908), Prentice (1923), Malhotra (1967) and the Roseta community (Stout et al 1964:845-849), the conclusion was the same: a diet consisting of up to 80% saturated fat was either protective against heart disease, cancer and stroke or neutral. These studies are the kinds of studies that are now probably no longer possible as very few communities still eat these traditional diets.…”

Section: Fat Warsmentioning

confidence: 99%

Climate wars and fat wars: A new role for law

Kroeze

2017

TDSA

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Public trust in science is eroding because of a number of conflicts. In the sphere of climate science and of nutrition science, a basic methodological difference between scientists has escalated into what can be called wars. These wars are the result of influences such as personalities of leading scientists and powerful commercial and political interests. The wars have escalated to such an extent that leading scientists are being threatened with legal action and disciplinary procedures for advocating divergent views. These legal processes are not primarily about the procedural aspects of their actions, but are couched as being ‘about the science’. This means that legal processes are being used to ‘settle’ the science – something that the law has never been required to do. This new role for law has implications for legal education and requires that lawyers become more capable to understand empirical research.

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Cardiovascular disease in the masai

Cited by 160 publications

References 28 publications

Effects of Exercise on Vascular Function, Structure, and Health in Humans

Effects of Exercise on Vascular Function, Structure, and Health in Humans

Outcome of the Public consultation on the Draft Opinion of the Scientific Panel on Dietetic Products, Nutrition, and Allergies (NDA) on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol

Climate wars and fat wars: A new role for law

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