2023
DOI: 10.1001/jama.2023.8184
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Cardiovascular Disease Prevention Recommendations From an Online Chat-Based AI Model

Abstract: developing therapeutic human antibodies, and financial interest in TenSixteen Bio, a company targeting somatic mosaicism and clonal hematopoiesis of indeterminate potential to discover and develop novel therapeutics to treat age-related diseases, and in Soley Therapeutics, a biotechnology company that is combining artificial intelligence with molecular and cellular response detection for discovering and developing new drugs, currently focusing on cancer therapeutics. Dr Bhatt reported receiving grants from Ama… Show more

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Cited by 2 publications
(2 citation statements)
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“…Regardless of the prediction class (AD/Unsure/CN), there does not appear to be a clear relationship between MMSE scores and the LLM chatbots' prediction performance for CN subjects (high MMSE scores are inherently limited in distribution). However, a significant subset of CN subjects with high MMSE scores (27)(28)(29)(30) tend to be misclassified as AD or Unsure by all three LLM chatbots, suggesting that high MMSE scores do not necessarily aid CN prediction; other factors, such as linguistic attributes or contextual cues, may offer a confounding impact on the LLM chatbots' prediction.…”
Section: Insights From Mmse Score Comparisonmentioning
confidence: 96%
See 1 more Smart Citation
“…Regardless of the prediction class (AD/Unsure/CN), there does not appear to be a clear relationship between MMSE scores and the LLM chatbots' prediction performance for CN subjects (high MMSE scores are inherently limited in distribution). However, a significant subset of CN subjects with high MMSE scores (27)(28)(29)(30) tend to be misclassified as AD or Unsure by all three LLM chatbots, suggesting that high MMSE scores do not necessarily aid CN prediction; other factors, such as linguistic attributes or contextual cues, may offer a confounding impact on the LLM chatbots' prediction.…”
Section: Insights From Mmse Score Comparisonmentioning
confidence: 96%
“…Large language model (LLM) chatbots such as OpenAI's Generative Pretrained Transformer (GPT, versions 3.5 and 4) and Google's Bard, demonstrate impressive capabilities in many domains, including healthcare settings [25][26][27], to support early detection and clinical assessment. Here, we explore the utility of LLM chatbots (ChatGPT-3.5, ChatGPT-4, and Bard) for identifying AD in individuals, using textual transcriptions derived from spontaneous speech: a non-trivial assessment task that currently poses significant challenges for other state-of-the-art detection modalities and could benefit immediately from advanced artificial intelligence techniques directly applied "in-the-field".…”
Section: Introductionmentioning
confidence: 99%