Cardiovascular Diseases and Natural Products

Zhu, Chen; Liu, Zhiwei; Peng, Yu; Leng, Li; Du, Li; Tao, Xiuxiang; Wang, Dongdong

doi:10.2174/138920372010190920124756

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higenamine in the concentration of 10 and 100 μM could increase the contraction frequency and contraction amplitude of primary cultured neonatal rat ventricular myocytes ( Han et al, 1981 ). Chen et al (2019b) , investigated the contractility of higenamine and ISO on adult rat cardiomyocytes. Studies have found that the stimulation of higenamine on cardiomyocytes was dose-dependent.…”

Section: Effects Of Higenamine On Heart Disease In Vitromentioning

confidence: 99%

“…In the past few decades, a large number of studies have shown that natural products and their related synthetic compounds have good clinical effects on the prevention, treatment and diagnosis of heart disease. Previous studies have revealed that higenamine showed better therapeutic effects on heart disease, including coronary artery disease (CAD), bradyarrhythmia, chronic heart failure (CHF), cardiac ischemia/reperfusion (I/R) injury, cardiac fibrosis, cardiorenal syndrome (CRS), etc., which have aroused great interest of researchers ( Chen Z. et al, 2019 ). In the oriental Asian countries, herbal medicines containing higenamine have been used to treat heart disease for thousands of years.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Higenamine in Heart Diseases: A Mini-Review

Wen

Zhang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Higenamine, a natural product with multiple targets in heart diseases, is originally derived from Aconitum, which has been traditionally used in China for the treatment of heart disease, including heart failure, arrhythmia, bradycardia, cardiac ischemia/reperfusion injury, cardiac fibrosis, etc. This study is aimed to clarify the role of higenamine in heart diseases. Higenamine has effects on improving energy metabolism of cardiomyocytes, anti-cardiac fibroblast activation, anti-oxidative stress and anti-apoptosis. Accumulating evidence from various studies has shown that higenamine exerts a wide range of cardiovascular pharmacological effects in vivo and in vitro, including alleviating heart failure, reducing cardiac ischemia/reperfusion injury, attenuating pathological cardiac fibrosis and dysfunction. In addition, several clinical studies have reported that higenamine could continuously increase the heart rate levels of healthy volunteers as well as patients with heart disease, but there are variable effects on systolic blood pressure and diastolic blood pressure. Moreover, the heart protection and therapeutic effects of higenamine on heart disease are related to regulating LKB1/AMPKα/Sirt1, mediating the β2-AR/PI3K/AKT cascade, induction of heme oxygenase-1, suppressing TGF-β1/Smad signaling, and targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway. However, the interventional effects of higenamine on heart disease and its underlying mechanisms based on experimental studies have not yet been systematically reviewed. This paper reviewed the potential pharmacological mechanisms of higenamine on the prevention, treatment, and diagnosis of heart disease and clarified its clinical applications. The literature shows that higenamine may have a potent effect on complex heart diseases, and proves the profound medicinal value of higenamine in heart disease.

show abstract

Section: Effects Of Higenamine On Heart Disease In Vitromentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%