Cardiovascular Diseases and Vital Exhaustion: Longitudinal Study in Russia/Siberia (Who Monica — Psychosocial Program)

Гафаров, В. В.; Воевода, М. И.; Громова, Е. А.; Maksimov, V. N.; Гагулин, И. В.; Yudin, N. A.; Гафарова, А. В.; Mishakova, T M

doi:10.15829/1560-4071-2016-4-eng-115-123

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The studies were limited by low event rates and this association was found only to be significant amongst women and smokers [10,11,27]. A separate study concerning vital exhaustion in Russia found that exhausted men aged 25-64-years were at a substantially higher risk of stroke than non-exhausted men over 14 years of follow-up (HR 2.6) [28]. Furthermore, we have previously shown that fatigue increased the hazards of cardiovascular mortality by 45% [4].…”

Section: Discussionmentioning

confidence: 96%

Self-Reported Fatigue Predicts Incident Stroke in a General Population

Barlas

Luben

Neal

et al. 2020

Stroke

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Background and Purpose— Fatigue is a common symptom among stroke survivors and in general practice. However, the clinical significance of fatigue and its relationship to incident stroke is unclear. The aim of this study was to examine the relationship between self-reported fatigue and the incidence of stroke in a general population. Methods— This was a prospective, population-based study. The study population was 15 654 men and women aged 39 to 79 years recruited in 1993 to 1997 and followed till March 2016. Fatigue was assessed at 18 months after baseline using the vitality domain of the Short Form 36 questionnaire. Cox proportional hazard models were constructed to describe the prospective relationship between baseline fatigue and incident stroke adjusting for age, sex, systolic blood pressure, cholesterol, physical activity, smoking status, alcohol consumption, fruit and vegetable consumption, diabetes mellitus, body mass index, vitamin supplement use, education level, Townsend deprivation index, and occupational social class. Incident stroke was ascertained using death certificates and hospital record linkage data. Results— Through 249 248 person-years of follow-up, 1509 incident strokes occurred. Participants who reported the highest level of fatigue (quartile 4) were more likely to be women, to be multimorbid, and to perceive their health as fair or poor. We observed ≈50% relative risk increase in stroke risk (hazard ratio, 1.49 [95% CI, 1.29–1.71]) in those who reported the highest level of fatigue compared with those who reported the lowest level of fatigue (Q4 versus Q1). This relationship remained unaltered regardless of anemia status, the presence or absence of chronic bronchitis, thyroid dysfunction, or depression. Conclusions— Self-report fatigue assessed by the vitality domain of the Short Form 36 questionnaire predicts the risk of future stroke at the general population level. Identifying and addressing stroke risk factors in those who report fatigue in general practice may have substantial benefit at the population level.

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Section: Discussionmentioning

confidence: 96%

Self-Reported Fatigue Predicts Incident Stroke in a General Population

Barlas

Luben

Neal

et al. 2020

Stroke

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“…VE was defined as feeling excessively tired, exhausted, irritable, and demoralized [3]. Over the past decade, VE has attracted considerable attention from researchers due to its adverse effects on health and well-being [4][5][6]. In particular, the conducted studies have shown that VE was an independent RF for the development and progression of CVD [2,[4][5][6][7], and men were at greater risk of developing CVD than women [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Over the past decade, VE has attracted considerable attention from researchers due to its adverse effects on health and well-being [ 4 , 5 , 6 ]. In particular, the conducted studies have shown that VE was an independent RF for the development and progression of CVD [ 2 , 4 , 5 , 6 , 7 ], and men were at greater risk of developing CVD than women [ 8 , 9 ]. At present, VE is an understudied CVD RF.…”

Section: Introductionmentioning

confidence: 99%

Association of Vital Exhaustion with Risk Factors for Cardiovascular Diseases, Quality of Life and Lifestyle in 41–44-Year-Old Muscovite Men

Котова

Rozanov

Kiselev

et al. 2021

IJERPH

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(1) Background: Vital exhaustion (VE) is no less of an important risk factor (RF) for cardiovascular diseases (CVD) and cardiovascular events than the well-known RFs. Insufficient knowledge of the relationship between VE and CVD RF, quality of life, and lifestyle was the rationale for this study. (2) Methods: We examined 301 Muscovite men 41–44 years of age. The categorization of RFs for CVD was carried out in accordance with conventionally considered criteria. In order to evaluate the lifestyle and quality of life in study participants, we were offering them a self-filling questionnaire developed by I.A. Gundarov. The presence of VE signs was assessed using a 14-item short version of the Maastricht Vital Exhaustion Questionnaire scale (MVEQ). All study subjects were classified into three ordered groups depending on the distribution of VE indicators by tertiles: Group 1 consisted of men with a low VE (0–2 points), Group 2 included males with a medium VE score (3–5 points), and Group 3 comprised subjects with high VE scores (6–14 points). To analyze the obtained data, we used one-way analysis of variance (ANOVA), Pearson’s chi-squaredtest (χ2), Goodman and Kruskal’s gamma, and linear regression analysis. (3) Results: We established that every third male (36.8%) had VE signs, while 10.6% of men had high VE levels. With an increase of VE in men, the frequency of arterial hypertension (AH) was increasing as well, and it was significantly higher in men with a high VE compared to their peers with a low VE (48.4% versus 33%; p = 0.03). A significant linear relationship was discovered between VE levels and excessive alcohol consumption (p = 0.001). The strongest linear associations were found between the VE level, and both psychosocial stress indicator and the amount of consumed ethanol. Self-assessment of personal happiness, job and sleep satisfaction, residential living conditions, and spiritual needs, as well as psychosocial stress indicator, total amount of consumed ethanol, and muscle strength (hand-grip dynamometry), were independent determinants of the VE level, and, collectively, they explained 46.6% of its variability. The greatest contribution to VE was made by the personal happiness level, explaining 25.5% of its variability. The proportions of the VE variance uniquely explained by various factors were as follows: 9.3% by the psychosocial stress, 4.9% by job satisfaction, 2.8% by sleep satisfaction, 2.3% by total consumption of ethanol, 1.6% by muscle strength, 1.1% by living conditions in the residential neighborhood, and just 0.8% by spiritual needs. (4) Conclusion: High VE levels in 41–44-year-old men areassociated with AH, sedentary behavior, excessive alcohol consumption, and lower values of most indicators of both lifestyle and quality of life.

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Psychosocial risk factors for cardiovascular disease: vital exhaustion and its associations with biochemical markers of inflammation among persons 25-44 years old

Gafarov,

Gromova,

Kashtanova

et al. 2023

Russ J Cardiol

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Aim. To study the association of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) levels with vital exhaustion (VE) among men and women aged 25-44 years in Novosibirsk.Material and methods. At the Research Institute of Internal and Preventive Medicine (Novosibirsk), during 2013-2016, a cross-sectional survey of a random representative sample of people aged 25-44 years in one of the typical districts of Novosibirsk was carried out. A total of 975 individuals were examined (403 men, 530 women). The response rate was 71%. General examination and history collection were carried out according to standard methods included in the WHO program "MONICA-psychosocial (MOPSY)". All study participants completed the Maastricht Vital Exhaustion Questionnaire (MQ).Results. High and medium VE prevailed among women (15,7% and 40,6%) than among men (5,5% and 32,8%) (p<0,001). Median serum levels of IL-6 were high VE among both sexes 1,41 [0,70;4,60] pg/ml, compared with medium VE 1,20 [0,65;2,90] pg/ml, and low VE 1,12 [0,58;2,32] pg/ml (p<0,01), and among women with high VE 1,53 [0,72;4,33] pg/ml, compared with medium VE 1,14 [0,63;2,36] pg/ml and low VE 0,95 [0,50;1,98] pg/ml (p<0,05). Serum TNF-α was higher among women with high VE (6,01±3,23 pg/ml) than with medium VE (5,63±4,16 pg/ml) and low VE (4,95±2,85 pg/ml) (p=0,025). Mean serum MCP-1 levels among both sexes, men and women, were higher with high VE (324,55±161,89 pg/ml, 270,75±107,92 pg/ml and 338,81±171,1 pg/ml) than with medium (251,78±123,4 pg/ml, 262,46±134,9 pg/ml and 245,22±115,61 pg/ml), and low VE (227,59±101,03 pg/ml, 234,51±104,53 pg/ml and 220,17±96,81 pg/ml) (p<0,001).Conclusion. An increase in the average levels of inflammation biochemical markers (IL-6, TNF-α, MCP-1) was established in individuals 25-44 years old with a high VE.

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Cardiovascular Diseases and Vital Exhaustion: Longitudinal Study in Russia/Siberia (Who Monica — Psychosocial Program)

Cited by 4 publications

References 32 publications

Self-Reported Fatigue Predicts Incident Stroke in a General Population

Self-Reported Fatigue Predicts Incident Stroke in a General Population

Association of Vital Exhaustion with Risk Factors for Cardiovascular Diseases, Quality of Life and Lifestyle in 41–44-Year-Old Muscovite Men

Psychosocial risk factors for cardiovascular disease: vital exhaustion and its associations with biochemical markers of inflammation among persons 25-44 years old

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