Cardiovascular Diseases in Obesity: What is the Role of Magnesium?

Santos, Loanne Rocha dos; Melo, Stéfany Rodrigues de Sousa; Silva, Juliana; Morais, Jennifer Beatriz Silva; Silva, Lyandra Dias da; Sousa, Mickael de Paiva; Sousa, Thayanne Gabryelle Visgueira de; Henriques, Gilberto Simeone; Marreiro, Dilina do Nascimento

doi:10.1007/s12011-020-02528-7

Cited by 12 publications

(12 citation statements)

References 67 publications

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“…Moreover, genes involved in lipogenesis, such as glucose-6-phosphate dehydrogenase, showed decreased activity in the liver 27 . Magnesium also stimulates lipoprotein lipase activity in the muscles, which lowers the concentration of triacylglycerols while increasing HDL-cholesterol levels 28 .…”

Section: Discussionmentioning

confidence: 99%

Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial

Salehidoost

Boroujeni

Feizi

et al. 2022

Sci Rep

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To evaluate the effect of magnesium supplementation on insulin resistance and cardiovascular markers in people with prediabetes. A 12 week double-blind placebo-controlled randomized clinical trial was conducted at Isfahan Endocrine and Metabolism Research Center, Iran, on people with prediabetes (n = 86) to compare the effects of magnesium oxide 250 mg/day versus a placebo on anthropometric indices, blood pressure, fasting glucose, insulin, HOMA-IR index, C-reactive protein, uric acid and lipid profile. Both groups had similar distributions of anthropometric and biochemical variables at baseline. Those who received magnesium supplementation had significantly higher levels of HDL-cholesterol compared to the placebo group at the end of the study (49.7 ± 10.9 vs 43.6 ± 7.2 mg/dL, P = 0.003). The mean changes of HOMA-IR index, total cholesterol, LDL-cholesterol, triglyceride, uric acid and C-reactive protein levels as well as anthropometric indices and blood pressure in supplemented and placebo groups did not differ significantly. Magnesium supplementation increased HDL-cholesterol levels in people with prediabetes. However, other cardiometabolic markers were not improved by magnesium supplementation at the above dosage and duration.

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Section: Discussionmentioning

confidence: 99%

Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial

Salehidoost

Boroujeni

Feizi

et al. 2022

Sci Rep

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“…The role of Mg in obesity, a state typically characterised by low intracellular Mg ++ , was reviewed recently. In that context, the regulation of serum lipids and lipid metabolism is impaired when Mg ++ is low and may predispose these individuals to a higher incidence of CVD (59) .…”

Section: Magnesiummentioning

confidence: 99%

Osteosarcopenic adiposity syndrome update and the role of associated minerals and vitamins

Ilich

2021

Proc. Nutr. Soc.

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The objectives are to present an updated synopsis on osteosarcopenic adiposity (OSA) syndrome and evaluate the roles of selected micronutrients in its prevention and management. OSA refers to the concurrent deterioration of bone (osteopenia/osteoporosis), muscle (sarcopenia) and adipose tissue expansion. It portrays the most advanced stage in a continuum of body composition disorders. Although OSA has been widely studied involving the populations of different backgrounds, its prevalence is hard to collate because different methodologies and criteria were used for its diagnosis. Another critical health aspect is the presence of low-grade chronic inflammation (LGCI) which contributes to OSA and vice versa. Nutrition is important in the prevention and management of both OSA and LGCI. Although micronutrients act in numerous metabolic and physiological processes, their roles here are presented in relation to OSA (and its components) and LGCI in general and relevant to the COVID-19 pandemic. These include calcium, magnesium, phosphorus, potassium, sodium and vitamins D and K; their interactions, physiological ratios and synergism/antagonism are discussed as well. In conclusion, calcium, magnesium and vitamin D have a profound impact on OSA and its components, and the latter two also on LGCI. Potassium and vitamin K are vital in bone, muscle functioning and possibly adipose tissue modification. Both, but particularly vitamin D, surfaced as important modulators of immune system with application in COVID-19 infections. While both phosphorus and sodium have important roles in bone, muscle and can impact adiposity, due to their abundance in food, their intake should be curbed to prevent possible damaging effects.

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“…Insufficient intake A diet low in Magnesium [102,105] Slimming cures [102,106] Intensification of losses At the gastrointestinal level: vomiting; purgatives/laxatives; trailing diarrhea [103,107,108] By the renal route: nephropathies; diuretics; chronic alcoholism; diabetes [104,[109][110][111][112][113][114][115] Table 2. Cont.…”

Section: Causes Of Magnesium Deficiencymentioning

confidence: 99%

“…C-reactive protein (CRP), a measure of systemic inflammation and a predictor of future cardiovascular events in individuals with MetS, and serum magnesium levels are inversely correlated [ 104 , 144 ]. At the same time, changes in the metabolism of several micronutrients were observed in obese patients, such as decreased magnesium concentrations in the serum, plasma, and erythrocytes [ 105 , 145 , 146 ]. Magnesium supplementation has been shown to have positive effects on patients with metabolic disorders in terms of their metabolic profile [ 109 ].…”

Section: Magnesium and Dyslipidemiamentioning

confidence: 99%

“…Magnesium is crucial for regulating the activity of several key enzymes involved in lipid metabolism, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) [ 126 , 155 ], which controls cholesterol biosynthesis; lecithin–cholesterol acyltransferase (LCAT), which lowers plasma concentrations of LDL-c and VLDL-c [ 99 , 105 ]; desaturase (DS) [ 12 , 99 ]; and lipoprotein lipase (LPL) [ 127 , 156 ]. LPL, DS, and LCAT activity are suppressed by hypomagnesemia, and Mg supplementation can positively affect their expression [ 130 , 155 ].…”

Section: Magnesium and Dyslipidemiamentioning

confidence: 99%

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The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Nartea

Mitoiu

Ghiorghiu

2023

CIMB

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Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins lower the frequency of cardiac events, stroke, and mortality, not by lowering LDL-C, but by the capacity to reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation and migration and encourage macrophages to promote plaque stability and regression while reducing inflammation. Taking these factors into consideration, we did an extensive analysis of the relevant literature, comparing the effects of Mg2 and statin medications on lipoproteins and, implicitly, on the key enzymes involved in cholesterol metabolism.

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Cardiovascular Diseases in Obesity: What is the Role of Magnesium?

Cited by 12 publications

References 67 publications

Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial

Effect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial

Osteosarcopenic adiposity syndrome update and the role of associated minerals and vitamins

The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

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