Cardiovascular Disorders Associated with Obstructive Sleep Apnea

Lurie, A.

doi:10.1159/000325110

Cited by 46 publications

(15 citation statements)

References 324 publications

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“…These findings indicate that although, all the TRD residual symptoms are not caused by OSA, patients with TRD could be at high risk for OSA and they should be evaluated for sleep apnea, particularly in subjects with loud snoring, medical diseases, fatigue, and Additional findings demonstrated a positive link between high risk for OSA and the frequency of medical comorbidity, such as hypertension, diabetes mellitus, and obesity. This is supported by evidence regarding the comorbidity of these medical conditions with both MDD and OSA (6,(47)(48)(49)(50)(51)(52). This study observed that obesity is the strongest risk factor for OSA, as 43 of 44 obese patients with TRD were at high risk for OSA (Table 3).…”

Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 58%

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Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Khazaie

Alavi-Mehr

Younesi

et al. 2018

Iran J Psychiatry Behav Sci

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Objectives: Studies have reported a higher risk for obstructive sleep apnea (OSA) in major depressive disorder (MDD). However, the risk of OSA in patients with chronic treatment-resistant depressive symptoms is not well documented worldwide. Hence, the current study assessed the risk of OSA and associated factors in patients with chronic treatment resistant depression (cTRD). Methods: The study recruited 140 Iranian patients with cTRD. All patients completed the Berlin questionnaire, which evaluates the risk of OSA. Additionally, demographic data and history of cardiovascular or metabolic diseases were collected. Pearson's Chi-square test, Fisher's exact test, and independent T-test were used to assess group differences, when appropriate. Results: The study found that 89 of 140 cTRD patients (64%) were at high risk for OSA. Group comparison between cTRD patients (high vs. low risk for OSA) demonstrated that at high risk OSA-cTRD patients had an elevated rate of hypertension, diabetes mellitus, and obesity. Also, age, duration of depression, and duration of treatment were significantly higher in cTRD patients with higher risk compared to those with lower risk for OSA. Conclusions:The results suggest that a noticeable number of patients with cTRD are at high risk for OSA, which is higher than the reported magnitude in the general population. Moreover, hypertension, diabetes mellitus, and obesity are associated with a higher risk for OSA. Also, age, treatment duration, and depression duration could be considered as possible comorbid factors for OSA in patients with cTRD.

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Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 58%

“…The prevalence of OSA in the general population is noticeable, which is 3% to 7% in males and 2% to 5% in females (5). Obstructive sleep apnea is considered as an independent risk factor for cardiovascular or metabolic comorbidities (6,7). Moreover, OSA is an important risk factor for neurocognitive impairment and emotional decline (8,9).…”

Section: Introductionmentioning

confidence: 99%

Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Khazaie

Alavi-Mehr

Younesi

et al. 2018

Iran J Psychiatry Behav Sci

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“…It has also been suggested that OSA may be independently associated with an increased risk of ischemic heart disease, stroke, arrhythmias and mortality (Lurie, 2011). OSA is characterized by repetitive partial or complete closure of the upper airway during sleep that results in hypoxemia and hypercapnia, is frequently associated with arousals, and leads to an increase in myocardial oxygen demand (Dorasamy, 2007).…”

Section: Introductionmentioning

confidence: 99%

Dietary and cardio-metabolic risk factors in patients with Obstructive Sleep Apnea: cross-sectional study

Stelmach-Mardas

Mardas

Iqbal

et al. 2017

PeerJ

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BackgroundLittle is known about the role of dietary intake in obstructive sleep apnea (OSA), which could prove important in improving clinical outcomes for people with obesity and/or cardiovascular disease within these populations. Reduction in energy intake typically results in weight loss, markedly improving metabolic parameters and ameliorating OSA severity. The aim of this study was to evaluate the association of dietary and cardio-metabolic risk factors with OSA severity.MethodsThis was a cross-sectional study. A total of 75 volunteers at risk of OSA were recruited from 153 patients suffering from sleep disturbance at the Department of Pulmonology, Allergology and Respiratory Oncology at the Poznan University of Medical Sciences. Polysomnography was used for OSA diagnosis. Sleep quality was assessed by the Pittsburgh Sleep Quality Index. Blood pressure, parameters of glucose (fasting glucose, glucose tolerance test) and lipid metabolism (TC, LDL-C, HDL-C, TG) were assessed using routine enzymatic methods. Dietary intake was evaluated by 24-hr dietary recalls and Food Frequency Questionnaire. Ordinal logistic regression models were used for association of background characteristics and dietary intake with OSA severity. All analyses were adjusted for age, sex, BMI, smoking and alcohol intake.ResultsA higher percentage of smokers were observed in patients with mild OSA, while alcohol intake was the highest in severe OSA patients. Approximately 60% of the studied patients were self-reported poor sleepers. Results from ordinal logistic regression models showed that higher intakes of alcohol intake were associated with increased odds of severe OSA; whereas higher HDL-C levels were associated with lower odds (OR 0.01; 95% CI [0.0003–0.55]). Significantly higher odds of high OSA severity were observed in patients with disturbed sleep stages and obstructive sleep apnea. Moreover, the investigation of nutrient intake in relation to OSA severity showed that a higher intake of dietary fiber was associated with decreased OSA severity (OR 0.84; 95% CI [0.71–0.98]).ConclusionsThe severity of OSA is related to higher alcohol consumption and disturbed sleep. The significantly lower dietary fiber intake in patients with severe OSA is of particular importance for dietary consulting in clinical practice, which may positively influence cardiometabolic outcomes.

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“…7,9 It is best diagnosed by overnight polysomnography and is defined by the apnea hypopnea index, which is the number of hypopnea and apnea events divided by the number of hours of sleep. Mild, moderate, and severe OSA is defined as a apnea hypopnea index of 5–15, 16–30, and >30, respectively.…”

Section: Introductionmentioning

confidence: 99%

High Rates of Obstructive Sleep Apnea Symptoms Among Patients With Schizophrenia

Annamalai¹,

Palmese²,

Chwastiak

et al. 2015

Psychosomatics

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Background Patients with schizophrenia have high rates of obesity and cardiovascular morbidity, which are strongly associated with obstructive sleep apnea (OSA). The prevalence and risk factors for OSA are not well studied in patients with schizophrenia. Objective The purpose of this study was to evaluate the frequency of OSA symptoms in a sample of outpatients with schizophrenia. Methods This cross-sectional study was a secondary analysis of data generated from an insomnia study that evaluated 175 outpatients with schizophrenia or schizo-affective disorder in a single, large urban community mental health center. Results of scales evaluating insomnia were used to complete the STOP questionnaire, which is a screening tool for OSA validated in surgical populations. Appropriate statistical analysis was done to compare participants across groups. Results Patients were classified into high risk for OSA (STOP ≥ 2) (57.7%), and low risk for OSA (STOP score < 2) (42.3%). We also identified patients with a known diagnosis of OSA (14.9%). Patients with diagnosed OSA had significantly higher STOP scores (mean 2.7 vs. 1.6 [t = 6.3; p < 0.001]). Only 23.8% of patients in the high-risk group were diagnosed with OSA. Body mass index was significantly higher in the diagnosed group (F[2,169] = 25; p < 0.001) as was diabetes (χ2 [2, N = 175] = 35, p < 0.001). Conclusion A large number of outpatients with severe mental illness are at high risk for OSA. The STOP questionnaire is easy to use and appears to have a very high clinical utility to detect OSA. Based on our findings, further studies are warranted to validate the tool in patients with severe mental illness.

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Cardiovascular Disorders Associated with Obstructive Sleep Apnea

Cited by 46 publications

References 324 publications

Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Higher Risk for Obstructive Sleep Apnea in Chronic Treatment-Resistant Depression

Dietary and cardio-metabolic risk factors in patients with Obstructive Sleep Apnea: cross-sectional study

High Rates of Obstructive Sleep Apnea Symptoms Among Patients With Schizophrenia

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