Cardiovascular Disturbances in Poliomyelitis

Weinstein, Louis

doi:10.1161/01.cir.15.5.735

Cited by 25 publications

(5 citation statements)

References 46 publications

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“…Infection causes poliomyelitis disease, a paralytic disease but 99% of the disease has since been eradicated following the introduction of the polio vaccine [80]. Myocardial involvement after poliovirus infection is very rare, reported in studies in the 1950s with almost no case reports on myocarditis in poliomyelitis in recent years, possible due to successful efforts in eradication of poliomyelitis [81][82][83].…”

Section: Poliovirusmentioning

confidence: 99%

Viral Cardiomyopathy: A Review of Clinical Status and Meta-Analysis of Diagnosis and Clinical Management

Albakri¹

2019

2516-7138

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From an aetiological standpoint, viral cardiomyopathy represents an uncommon subtype of non-inflammatory dilated cardiomyopathy. The most common aetiologic agents are enteroviruses, adenoviruses and erythroviruses. Pathogenesis depends on the causative virus. Enteroviruses and adenoviruses infect and injure the cardiomyocyte through cytopathic effect and immune-mediated damage leading to cardiac remodelling, myocarditis and ultimately cardiomyopathy. Erythroviruses infect and injure the vascular endothelial cells resulting in macrovascular dysfunction. Typical clinical presentation is heart failure, arrhythmias and chest pains. Clinical diagnosis requires the presence of electrocardiographic abnormalities, markers of myocardial necrosis or evidence of functional/structural ventricular abnormalities accompanied by at least one physical sign or clinical symptom. However, endomyocardial biopsy remains the reference standard but increased risks of complications and the need for highly experienced operators limits its widespread use. The available clinical management strategies are standard heart failure medication for the management of cardiac dysfunction and antiarrhythmic drugs for those with ventricular arrhythmias. Patients with refractory symptoms greater than six months despite optimal medical therapy and with biopsy-proven virus negative myocardium may benefit from supplementary immunosuppressive therapy. However, largescale and long-term prospective randomized clinical trials are warranted to determine long-term benefits of immunosuppression.

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Section: Poliovirusmentioning

confidence: 99%

Viral Cardiomyopathy: A Review of Clinical Status and Meta-Analysis of Diagnosis and Clinical Management

Albakri¹

2019

2516-7138

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“…changes in poliomyelitis. Weinstein (1957) believes that such studies indicate greater frequency of myocarditis than is shown by anatomical studies, and considers that, while dysfunction of the nervous system and abnormal ventilation may account for minor E.C.G. changes, major and more persistent ones are related to myocarditis.…”

Section: Clinical Summaries and Pathologymentioning

confidence: 99%

“…Though a number of factors, including cardiac involvement, have been suggested in its pathogenesis, Weinstein (1957), along with others, believes that "destruction of the medulla is the keystone of this phenomenon." Case 3 supports this view, as C.N.S.…”

Section: Clinical Summaries and Pathologymentioning

confidence: 99%

“…Sudden death in poliomyelitis may have an association with myocarditis, as it was found in all of 14 subjects dying suddenly in a total of 28 fatalities (Shutkin, 1951). Weinstein (1957) points out that it is difficult to distinguish the origin of cardiovascular dysfunction among the competing factors arising from possible involvement of myocardium, lungs, and medulla. Among the welter of neurological and ventilatory disturbance in our five cases it would have been hard to say that clinical evidence of myocarditis existed.…”

Section: Clinical Summaries and Pathologymentioning

confidence: 99%

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Occurrence of Myocarditis in Paralytic Poliomyelitis

Galpine¹,

Wilson²

1959

BMJ

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“…Essentially, two hypotheses have been put forward [55]: 1. Essentially, two hypotheses have been put forward [55]: 1.…”

Section: Introductionmentioning

confidence: 99%

Notes on the pathogenesis of enterovirus infections

Eggers

1990

Med Microbiol Immunol

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Despite extensive investigations over the last decades, several aspects of the pathogenesis of enterovirus infections in humans and animals are only poorly understood, such as the molecular basis of virulence (in particular of neurovirulence), tissue tropisms (e.g. the precise site of initial virus replication in the human intestinal tract), and precipitating factors of paralytic disease ("disposition"). Studies on poliovirus myocarditis in man are reviewed. Unequivocal evidence on replication of poliovirus type 2 (strains MEF1 and Lansing) in newborn and suckling mice and on poliovirus myocarditis is presented. Our observations strengthen the thesis of similar pathogenic potentials of the enterovirus group.

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Cardiovascular Disturbances in Poliomyelitis

Cited by 25 publications

References 46 publications

Viral Cardiomyopathy: A Review of Clinical Status and Meta-Analysis of Diagnosis and Clinical Management

Viral Cardiomyopathy: A Review of Clinical Status and Meta-Analysis of Diagnosis and Clinical Management

Occurrence of Myocarditis in Paralytic Poliomyelitis

Notes on the pathogenesis of enterovirus infections

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