Cardiovascular drug adverse reactions in hospitalized patients in cardiac care unit

Karimzadeh, Iman; Namazi, Soha; Shalviri, Gloria; Gholami, Kheirollah

doi:10.5897/ajpp10.413

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…CNS related ADRs were also prevalent in the study of Karimzedah et al 2011 20 and Singhal et al 21 The most frequent ADRs seen in the present study were headache and rashes due to ARB, statins, antianginals, beta-blockers. Singhal et al 21 and Karimzedah et al 20 reported headache as the most common ADR. Mohebbi et al 14 reported the skin hypersensitivity reactions as the most commonly occurring ADR.…”

Section: Discussionsupporting

confidence: 50%

Pattern and incidence of adverse drug reactions observed in cardiac clinic of tertiary hospital, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi

Singh

Dwivedi

Gupta

2015

Int J Basic Clin Pharmacol

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Section: Discussionsupporting

confidence: 50%

Pattern and incidence of adverse drug reactions observed in cardiac clinic of tertiary hospital, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi

Singh

Dwivedi

Gupta

2015

Int J Basic Clin Pharmacol

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“…The primary diagnosis at admission and the duration of CCU stay were reported to be risk factors for ADR development. (42) In the present study, the duration of hospital stay was significantly longer for the male patients than for the female patients. CCU stay was significantly longer for patients aged ≥ 60 years and male patients aged ≥ 60 years.…”

Section: Discussionmentioning

confidence: 58%

“…(16) One study reported that ADRs related to the central and peripheral nervous systems were more common in CCUs. (42) Cardiovascular drugs could result in fatal adverse reactions in CCU patients. The primary diagnosis at admission and the duration of CCU stay were reported to be risk factors for ADR development.…”

Section: Discussionmentioning

confidence: 99%

Age- and gender-related differences in drug utilisation and adverse drug reaction patterns among patients in a coronary care unit

Kunnoor¹,

Devi²,

Kamath³

et al. 2014

smedj

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INTRODUCTIONThis study aimed to examine age-and gender-related differences in the comorbidities, drug utilisation and adverse drug reaction (ADR) patterns of patients admitted to a coronary care unit (CCU). MeThODsThe present study was a retrospective cohort study. Two trained physicians independently reviewed the case records of CCU patients over a period of one year (Jan-Dec 2008). The demographic, clinical, and drug prescription data of the patients were analysed according to age group (18-59 years vs ≥ 60 years) and gender.ResUlTs A total of 574 patients were admitted to the CCU during the study period. Of these 574 patients, 65.2%were male, and 48.4% were ≥ 60 years old. No significant gender-based differences were found for the prescription of cardiovascular and non-cardiovascular drugs, and ADR patterns (p > 0.05). Male patients aged ≥ 60 years were found to have a higher rate of polypharmacy than those aged 18-59 years (p = 0.001). The duration of hospital stay was longer in male than female patients (p = 0.008), and the duration of CCU stay was longer for male patients aged ≥ 60 years than males aged 18-59 years (p = 0.013). Compared to patients aged 18-59 years, a greater number of patients aged ≥ 60 years were prescribed cardiovascular (p = 0.006) and non-cardiovascular drugs (p = 0.015). Patients aged ≥ 60 years also had a higher rate of polypharmacy (p = 0.001) and ADRs (p = 0.013), and a longer duration of CCU stay (p = 0.013). Renal (p = 0.047) and cutaneous (p = 0.003) ADRs were found to be more common in patients aged ≥ 60 years. CONClUsIONNo major gender-related differences were observed in the prescription, drug utilisation and ADR patterns of our study cohort. Higher drug utilisation, ADR rates, and longer duration of CCU stay were noted in patients aged ≥ 60 years.

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“…These results are compliance with the finding suggested by Karimzadeh et al (62.86%) and Khurshid et al (57%) which showed majority of reactions to be possible in nature. 29,38 However, a study conducted by Chan et al showed more of probable ADRs (41.4%). 31 This discrepancy in the present study could be due to different healthcare settings and types of ADRs reported.…”

Section: Discussionmentioning

confidence: 96%

Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Wadhwa¹,

Sheikh²,

Rao³

2018

IJOPP

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Context: Adverse drug reactions (ADRs) can result in a number of consequences, ranging from allergic reactions to permanent harm thereby causing morbidity and mortality leading to an increase in the health care costs. Aims: The main objective of the present study was to assess the prevalence of adverse drug reactions due to cardiovascular drugs in patients admitted to a secondary care hospital. Material and Methods: This was a prospective surveillance study which included adult patients of either gender who were hospitalized and prescribed with at least one cardiovascular drug. Patients were monitored from the day of admission till the day of discharge for the occurrence of ADRs due to cardiovascular drugs by attending clinical meetings, ward rounds, reviewing patients' medical records and electronic medical records. Results: A total of 309 patients were enrolled in the present study. Among them, 72 patients experienced 109 ADRs accounting for an incidence of 23.3%. Twelve (3.88%) patients were hospitalized due to ADRs (n=16) whereas 60 (19.41%) patients developed ADRs (n=93) during their hospital stay. Male preponderance was observed over female. Patients with age ≥ 60 years experienced 73 ADRs. The most common drug class implicated in ADRs was observed to be beta blockers (18; 16.5%) especially bisoprolol (16; 14.68%). Majority of patients experienced bradycardia (11; 10.09%) followed by hypotension (9; 8.26%). Cardiovascular system (30; 27.53%) was observed to be the most common system. Majority of ADRs were possible (80; 73.39%) in nature, mild (53%) in severity and not preventable (84.5%). Conclusion: Intensive approach towards monitoring and reporting of ADRs could help healthcare professionals in minimizing preventable ADRs.

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Cardiovascular drug adverse reactions in hospitalized patients in cardiac care unit

Cited by 8 publications

References 21 publications

Pattern and incidence of adverse drug reactions observed in cardiac clinic of tertiary hospital, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi

Pattern and incidence of adverse drug reactions observed in cardiac clinic of tertiary hospital, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi

Age- and gender-related differences in drug utilisation and adverse drug reaction patterns among patients in a coronary care unit

Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

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