Cardiovascular dysautonomia after seizures induced by maximal electroshock in Wistar rats

Damasceno, Dênis Derly; Ferreira, Anderson J.; Doretto, Maria Carolina; Almeida, Alvair P.

doi:10.1016/j.seizure.2012.07.015

Cited by 13 publications

(8 citation statements)

References 42 publications

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“…This result is in line with the clinical data (27,28). In consistence with the present results, Damasceno et al reported that epileptic seizure induced by both maximal electroshock and acoustic stimulation increased the incidence and duration of I/R-induced ventricular arrhythmias in isolated rat hearts (10,29). In contrast with this finding, Tavares et al reported in their in vivo study that pilocarpine-induced seizure activity did not affect the incidence of ventricular arrhythmias during ischemia and reperfusion periods (11).…”

Section: Discussionsupporting

confidence: 92%

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

2018

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Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in anesthetized rats for 30 min. The incidence and the number of ventricular arrhythmias were determined. Histopathological scoring was performed for tissue injury by using a microscope. Results: Seizure scores were not different among the groups (P > 0.05). The incidence and number of ventricular tachycardia (VT) episodes were significantly higher in the PTZ + ischemia group than in the ischemia group (P ˂ 0.05). More prominent myocardial damage was observed in the PTZ + ischemia group than in the other groups (histopathological scores: PTZ + ischemia; 2.5 ± 0.5 versus ischemia; 1.2 ± 0.4, P ˂ 0.05). Conclusion: PTZ-induced seizure in rats increased myocardial injury and the incidence and number of VT episodes in myocardial ischemia. These results reveal that seizure in epilepsy patients may increase ventricular arrhythmia and myocardial injury during heart attack.

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Section: Discussionsupporting

confidence: 92%

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

2018

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“…In a previous study, 12 we observed that convulsive seizures triggered by maximal electroshock (MES) induced profound abnormalities in cardiac rhythm and increased the incidence/ duration of ischemia-reperfusion arrhythmias in Wistar rats. Furthermore, Metcalf et al 13 suggested that status epilepticus produces tachycardic ischemia, following the activation of the sympathetic nervous system in rats, resulting in cardiac myofilament damage, arrhythmogenic alterations in cardiac electrical activity, and increased susceptibility to ventricular arrhythmias.…”

Section: Introductionmentioning

confidence: 99%

Cardiac dysfunction in rats prone to audiogenic epileptic seizures

Damasceno

Savergnini

Gomes

et al. 2013

Seizure

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“…Some animal[ 15 16 ] and human[ 17 18 ] studies have examined cardiac electrophysiological changes with ECS/ECT. Different studies examined different cardiac electrophysiological measures at different times with reference to the seizure, and none were designed in a way that allows comparisons with our study.…”

Section: Discussionmentioning

confidence: 99%

Effects of electrical stimulus composition on cardiac electrophysiology in a rodent model of electroconvulsive therapy

Singh

Sathyaprabha

Thirthalli

et al. 2018

Indian J Psychiatry

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Background:No electroconvulsive therapy (ECT) study on humans or in animal models has so far examined whether differently composed electrical stimuli exert different cardiac electrophysiological effects at constant electrical dose. The subject is important because cardiac electrophysiological changes may provide indirect information about ECT seizure quality as modulated by stimulus composition.Materials and Methods:Adult female Wistar rats (n = 20/group) received fixed, moderately suprathreshold (18 mC) electrical stimuli. This stimulus in each of eight groups was formed by varying pulse amplitude, pulse width, pulse frequency, and stimulus duration. The electrocardiogram was recorded, and time and frequency domain variables were examined in 30 s epochs in preictal (30 s before electroconvulsive shock [ECS]), early postictal (starting 15 s after stimulation), and late postictal (5 h after ECS) periods. Alpha for statistical significance was set at P < 0.01 to adjust for multiple hypothesis testing.Results:Cardiac electrophysiological indices in the eight groups did not differ significantly at baseline. At both early and late postictal time points, almost no analysis yielded statistically significant differences between groups for four time domain variables, including heart rate and standard deviation of R-R intervals, and for six frequency domain variables, including low-frequency power, high-frequency power, and total power.Conclusions:Cardiac electrophysiological measures may not be helpful to identify differences in seizure quality that are driven by differences in the composition of electrical stimuli at constant, moderately suprathreshold electrical dose. The generalization of this conclusion to threshold electrical doses and to human contexts requires a study.

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Cardiovascular dysautonomia after seizures induced by maximal electroshock in Wistar rats

Abstract: The present study supports a relationship betweem seizures, cardiac dysfunction and cardiac arrhythmias. This relationship may partially account for the occurrence of SUDEP.

Cited by 13 publications

References 42 publications

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

Cardiac dysfunction in rats prone to audiogenic epileptic seizures

Effects of electrical stimulus composition on cardiac electrophysiology in a rodent model of electroconvulsive therapy

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