Cardiovascular Effects of Aging Interrelationships of Aortic, Left Ventricular, and Left Atrial Function

Kallaras, Konstantinos; Sparks, Elizabeth; Schuster, Dara; Osei, Kwame; Wooley, Charles F.; Boudoulas, Harisios

doi:10.1007/s00059-001-2259-1

Cited by 19 publications

(28 citation statements)

References 27 publications

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“…It is also known that aortic distensibility decreases, while PWV and LV mass increase with age (6). In the present study, however, the association between GHb, aortic distensibility and LV mass persists after adjustment for age.…”

Section: Discussioncontrasting

confidence: 68%

“…It is known that a decreased aortic distensibility and/or increased PWV (i.e. stiffer aorta) often are present in patients with atherosclerosis, arterial hypertension, diabetes mellitus and older age (6,11,12). Epidemiologic studies have shown that aortic stiffness is a prognostic indicator for cardiovascular morbidity and mortality in the general population, independent of other risk factors (13,14).…”

Section: Discussionmentioning

confidence: 99%

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Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance

et al. 2007

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Objective: An association between glycosylated hemoglobin (GHb) and cardiovascular mortality in nondiabetic individuals has recently been reported. Prompt detection of nondiabetic individuals with high-normal GHb and early cardiovascular involvement may be of value for preventive strategies. In this investigation, a possible relationship between GHb, aortic function and left ventricular (LV) mass in nondiabetic individuals has been studied. Methods: A total of 263 nondiabetic African-Americans, aged 22-63 (mean 42G8) years were studied. All individuals were first degree relatives of diabetic patients, had normal oral glucose tolerance test (2-h OGTT) and decreased peripheral action of insulin. LV diameters and mass (echocardiography); ascending and abdominal aortic distensibility (echocardiography, arterial pressure); pulse wave velocity (PWV; electrocardiography, Doppler); fasting glucose; GHb; insulin sensitivity index (S I ) and 2-h OGTT were measured. Multiple linear and logistic regression analyses were used to identify significant independent associations of fasting glucose; GHb; S I and 2-h OGTT with aortic function and LV mass. Results: In fully adjusted multivariate logistic regression analysis, GHb predicted lower values of aortic distensibility (odds ratio (OR) 1.67 95% CI (1.04-2.75), PZ0.04); higher PWV (OR 1.79 95% CI (1.09-2.93), PZ0.022); and higher values of LV mass (OR 1.56 95% CI (1.08-2.88), PZ0.029). Fasting glucose, S I , and 2 h OGTT were not associated with aortic function and LV mass. Conclusion: Higher GHb concentrations, even within 'normal' range, are independently associated with stiffer aorta and increased LV mass and thus may detect nondiabetic individuals at increased cardiovascular risk.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance

et al. 2007

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“…Previous studies from our group demonstrated that aortic function and LA work, as defined by an increase in LA kinetic energy, were directly related to age whereas the parameters of LV size and function were unaffected [70,71,72]. It is also well documented from many studies that the aorta becomes stiffer with age.…”

Section: Metabolic/endocrinologic Disorders and Diseasesmentioning

confidence: 71%

“…It will also result in an increase in reflected wave velocity and systolic hypertension, which may result in an increase in LV work and mass. Aging may also have direct detrimental effects on the entire cardiovascular system (modified from [71]). …”

Section: Metabolic/endocrinologic Disorders and Diseasesmentioning

confidence: 99%

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The Left Atrium: From the Research Laboratory to the Clinic

et al. 2014

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Studies of left atrial (LA) function, until the latter part of the 20th century, were mostly limited to experimental animal models and to studies related to clinical research in the cardiac catheterization laboratory. For this reason, LA function has received considerably less attention than left ventricular (LV) functions, even though evidence suggests that LA myopathy and failure may exist as an isolated entity, precede and/or coexist with LV myopathy. The introduction of echocardiography and Doppler echocardiography in clinical practice has contributed significantly to our understanding of LA function and its interrelationships with the LV, aorta, pulmonary artery and other parts of the cardiovascular system. In addition, LA with the secretion of atrial natriuretic peptides is playing an important role in cardiovascular and neurohumoral homeostasis. Today, it is well known that LA structural and functional abnormalities that are present in many diseases and disorders constitute a powerful prognostic indicator. As technology (echocardiography, magnetic resonance imaging, computed tomography and others) continues to evolve, it is expected that, in the near future, LA structure and function will be routinely used as LV function is used today.

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Durable and Flexible PET‐Based Bending Sensor Obtained by Immobilizing Carbon Nanotubes via Surface Micro‐Dissolution for Body Motion Monitoring

Yang

et al. 2021

Macro Materials & Eng

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Textile-based conductive materials that can retain their electrical conductivity during bending have been extensively investigated and applied in flexible electronics and wearable sensors; however, the fastness of the conductive components in textiles requires improvements. Herein, a facile and effective surface micro-dissolution method is developed to prepare carbon nanotubes (CNTs)-coated PET fabric by embedding CNTs onto the surface of PET fabric. The micro-dissolved layer of the macromolecule served as a physical adhesion agent to firmly immobilize the CNTs on the PET fabric. The CNTs-coated PET fabric exhibited an electrical conductivity of 98.1 Ω □ −1 , durability during washing (over 30 cycles) and abrasion cycles (over 500 cycles), and remained conductive in harsh environments (high temperature, high humidity, water, corrosive liquids, organic solvents). The sensor (CCPFS) assembled by the CNTs-coated PET fabric is flexible (over 500 bending cycles), highly sensitive (1.48 deg −1 ), responsive (100 ms), and showed a relaxation time of 200 ms. The CCPFS is used to monitor movements in human fingers, wrist, elbow, knee, expiration, breathing, and wrist pulses. This research provides a route to manufacture flexible sensors for next-generation intelligent wearable devices.

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Cardiovascular Effects of Aging Interrelationships of Aortic, Left Ventricular, and Left Atrial Function

Cited by 19 publications

References 27 publications

Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance

Association between glycosylated hemoglobin, left ventricular mass and aortic function in nondiabetic individuals with insulin resistance

The Left Atrium: From the Research Laboratory to the Clinic

Durable and Flexible PET‐Based Bending Sensor Obtained by Immobilizing Carbon Nanotubes via Surface Micro‐Dissolution for Body Motion Monitoring

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