Cardiovascular effects of arsenic: clinical and epidemiological findings

Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling

“…Arsenic exposure was linked to both carcinogenic and non-carcinogenic diseases. Several studies have associated high-level of arsenic exposure from drinking water with elevated risk of vascular diseases, including peripheral vascular disease, hypertension, ischemic heart disease and carotid atherosclerosis [6]. Epidemiological studies reported increased incidence of hypertension in arsenic-exposed populations [7][8][9].…”

Environmental Exposures and Cardiovascular Disease

“…Chronic arsenic exposure is associated with subclinical cardiovascular disease, including increased carotid intimal-medial thickness, which has been observed in several studies in LMIC including Mexico and Bangladesh 156,160,161 . Moreover, left ventricular ejection fraction is reduced in children chronically exposed to arsenic in Mexico 157 .…”

“…While elevated blood pressure and hypertension in response to arsenic exposure has been observed in multiple LIMC settings including India, Bangladesh, Mexico and China, this observation has not been consistent 152–158 . Additionally, Type 2 Diabetes Mellitus, elevated triglycerides, and elevated total cholesterol have also been observed in association with arsenic exposure 142,156,159 .…”

Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction

“…Epidemiology studies have shown that arsenic exposure is associated with increased risk of cardiovascular diseases, including hypertension and peripheral vascular diseases [5]. Although decreased NO bioavailability is one important factor in the arsenicderived development of these diseases, its detailed mechanism has yet to be defined.…”

“…Several epidemiological studies have shown that chronic (and perhaps acute) exposure to arsenite is associated with increased risk for a variety of human diseases, including cardiovascular diseases (CVD) like arteriosclerosis, hypertension, and blackfoot disease [5]. Although the molecular mechanism by Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/freeradbiomed which arsenite causes cardiovascular dysfunction has yet to be fully clarified, the immediate and strong binding of arsenite to the sulfhydryl groups of many important proteins in target cells, such as cardiac, smooth muscle, and endothelial cells (EC), is one of the proposed mechanisms [6,7].…”