Cardiovascular effects of berberine in patients with severe congestive heart failure

Neto, J.A. Marin; Maciel, Benedito Carlos; Secches, Antonio L.; Gallo, L

doi:10.1002/clc.4960110411

Cited by 107 publications

(55 citation statements)

References 14 publications

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“…Limited clinical trials suggest that berberine is quite safe in human (46). Further studies in animals and in patients are required to recognize the full potential of this important constituent of ancient medicine.…”

Section: Discussionmentioning

confidence: 99%

Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

et al. 2008

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Berberine, an isoquinoline alkaloid derived from a plant used traditionally in Chinese and Ayurvedic medicine, has been reported to exhibit chemopreventive and anti-inflammatory activities through unknown mechanism. Because of the critical role of the transcription factor nuclear factor-KB (NF-KB) in these processes, we investigated the effect of berberine on this pathway. We found that berberine suppressed NF-KB activation induced by various inflammatory agents and carcinogens. This alkaloid also suppressed constitutive NF-KB activation found in certain tumor cells. Suppression of NF-KB activation occurred through the inhibition of phosphorylation and degradation of IKBA by the inhibition of IKB kinase (IKK) activation, leading to suppression of phosphorylation and nuclear translocation of p65, and finally to inhibition of NF-KB reporter activity. Inhibition of IKK by berbeine was direct and could be reversed by reducing agents. Site-specific mutagenesis suggested the involvement of cysteine residue 179 in IKK.

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Section: Discussionmentioning

confidence: 99%

Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

et al. 2008

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“…7,8) Moreover, cardiotonic 9) and antiarrhythmic 10,11) activities have also been reported. Despite the considerable works done on berberic species in inflammation, cardiotonic and antiarrhythmic effects, its effects and roles in ischemic damage in the brain remains to be elucidated.…”

mentioning

confidence: 98%

Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia

Yoo

Hwang

Lim

et al. 2006

Biological & Pharmaceutical Bulletin

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Transient forebrain ischemia, produced by prolonged deprivation of blood flow to the brain, results in the insidious delayed degeneration of specific vulnerable neurons within the hippocampus.1,2) Among hippocampal neurons, pyramidal cells of the hippocampal CA1 region are most vulnerable to cerebral ischemia. 1,2) Death of the CA1 pyramidal cells following cerebral ischemia causes a variety of neurological dysfunction such as depression and memory deficits. 3,4) In traditional Eastern medicine, the extracts of various Berberidaceae (Berberis aquifolium, Berberis vulgaris and Berberis aristata) are used for rheumatic complaints and other types of chronic inflammation. 5,6) It has been reported that the functional components of the extracts were alkaloid components such as berberine, oxyacanthine, berbamine and palmatine.5) The anti-inflammatory and immunosuppressive activity of the Berberidaceae extract is well established. 7,8) Moreover, cardiotonic 9) and antiarrhythmic 10,11) activities have also been reported. Despite the considerable works done on berberic species in inflammation, cardiotonic and antiarrhythmic effects, its effects and roles in ischemic damage in the brain remains to be elucidated.It has been postulated that the neuronal hyperactivity due to an elevation of extracellular excitatory amino acids during ischemia leads to a massive increase in intracellular-free Ca 2ϩ , which may trigger the process of neuronal degeneration. [12][13][14] In the present study, therefore, we investigated the percentage of berberine by HPLC, which is active ingredient, and the neuroprotective effects of crude berberry extract (BE) against ischemic damage and the temporal and spatial alterations of N-methyl-D-aspartate receptor type 1 (NR1) and NR2A/B, the major excitatory amino acid receptors, immunoreactivities in the hippocampus induced by transient ischemia to examine anti-ischemic effects and their roles after transient forebrain ischemia in gerbils. MATERIALS AND METHODS Experimental Animals Male Mongolian gerbils (Meriones unguiculatus) obtained from the Experimental AnimalCenter, Hallym University, Chunchon, South Korea were used in this study. The animals were housed at constant temperature (23°C) at 60% relative humidity under a fixed 12 h light/dark cycle and had free access to food and water. Procedures involving animals and their care conformed with the our institution's guidelines, which are in compliance with current international laws and policies (NIH Guide for the Care and Use of Laboratory Animals, NIH Publication No. 85-23, 1985, revised 1996). All experiments were conducted to minimize the number of animals used and suffering caused.Plant Materials and Extraction Korean berberry (Berberis koreana) was collected in the area around Gyeonggi-do (South Korea) in September 2001. The plants were authenticated and the voucher specimen was deposited in the departmental herbarium of Kangwon National University. For the preparation of the ethanol extract of Berberis koreana, whole plants of theBerberis k...

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“…Among the many biological actions described for BER, antitumoral/antiproliferative [28][29][30], antioxidant [31], and antiarrhythmic [32] are the most relevant. The beneficial potential of BER includes cardioprotective effects [32][33][34], since it was able to reduce ventricular afterload and augment myocardial contractibility [33,34]. On the other hand, BER also increases Sirt3 activity which results in the activation of mitochondrial biogenesis pathways and increased mitochondrial capacity [35,36].…”

Section: Introductionmentioning

confidence: 99%

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts

Coelho

Martins

Couto

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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A B S T R A C TDoxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However, treatment with DOX is associated with cumulative cardiotoxicity inducing progressive cardiomyocyte death. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, regulates the activity of proteins involved in apoptosis, autophagy and metabolism. Our hypothesis is that pharmacological modulation by berberine (BER) pre-conditioning of Sirt3 protein levels decreases DOX-induced cardiotoxicity. Our results showed that DOX induces cell death in all experimental groups. Increase in Sirt3 content by transfection-mediated overexpression decreased DOX cytotoxicity, mostly by maintaining mitochondrial network integrity and reducing oxidative stress. p53 was upregulated by DOX, and appeared to be a direct target of Sirt3, suggesting that Sirt3-mediated protection against cell death could be related to this protein. BER pre-treatment increased Sirt3 and Sirt1 protein levels in the presence of DOX and inhibited DOX-induced caspase 9 and 3-like activation. Moreover, BER modulated autophagy in DOX-treated H9c2 cardiomyoblasts. Interestingly, mitochondrial biogenesis markers were upregulated in in BER/DOX-treated cells. Sirt3 over-expression contributes to decrease DOX cytotoxicity on H9c2 cardiomyoblasts, while BER can be used as a modulator of Sirtuin function and cell quality control pathways to decrease DOX toxicity.

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Cardiovascular effects of berberine in patients with severe congestive heart failure

Cited by 107 publications

References 14 publications

Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia

Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts

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