Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice

Pote, William; Tagwireyi, Dexter; Chinyanga, H. M.; Musara, Colin; Nyandoro, George; Chifamba, Jephat; Nkomozepi, Pilani

doi:10.1016/j.jep.2013.03.001

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Nonetheless, few studies have addressed the long-term consequences of the exposure to elevated corticosterone levels during postnatal life using animal models. The glucocorticoid-induced changes in both central and peripheral sites of cardiovascular control may be reflected in enhanced cardiovascular responses to acute stress seen in MatSep mice (Pote et al, 2013) and rats (Loria et al, 2010b). Meaney’s group has demonstrated that offspring exposed to less maternal care display elevated glucocorticoid responses to stress (Weaver et al, 2004).…”

Section: Mechanisms Contributing To Els-induced Cardiovascular Dysmentioning

confidence: 99%

Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents

Murphy

Cohn

Loria

2017

Neuroscience & Biobehavioral Reviews

103

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The Developmental Origins of Health and Disease (DOHaD) hypothesizes that environmental insults during childhood programs the individual to develop chronic disease in adulthood. Emerging epidemiological data strongly supports that early life stress (ELS) given by the exposure to adverse childhood experiences is regarded as an independent risk factor capable of predicting future risk of cardiovascular disease. Experimental animal models utilizing chronic behavioral stress during postnatal life, specifically maternal separation (MatSep) provides a suitable tool to elucidate molecular mechanisms by which ELS increases the risk to develop cardiovascular disease, including hypertension. The purpose of this review is to highlight current epidemiological studies linking ELS to the development of cardiovascular disease and to discuss the potential molecular mechanisms identified from animal studies. Overall, this review reveals the need for future investigations to further clarify the molecular mechanisms of ELS in order to develop more personalized therapeutics to mitigate the long-term consequences of chronic behavioral stress including cardiovascular and heart disease in adulthood.

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Section: Mechanisms Contributing To Els-induced Cardiovascular Dysmentioning

confidence: 99%

Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents

Murphy

Cohn

Loria

2017

Neuroscience & Biobehavioral Reviews

103

View full text Add to dashboard Cite

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“…Treatment with an aqueous ethanolic extract of Boophone disticha can signicantly reduce acute mixing stress-induced blood pressure response in adult BALB/c early maternally separated mice. 76 While the extracts from the bulbs and leaves from Pancratium illyricum L. did not show any antibacterial activity, they revealed the remarkable yeast growth inhibitory activity with endpoint IC 50 values ranging from 1.22 to 78 mg mL À1 . 77 Lycorine, identied as the major components of both extracts, turned out to be highly active in inhibiting the yeast growth with endpoint IC 50 values ranging from 0.89 to 28.5 mg mL À1 .…”

Section: Biological Activity and Biosynthesismentioning

confidence: 95%

Amaryllidaceae and Sceletium alkaloids

Jin

2016

Nat. Prod. Rep.

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“…Circulating endothelin-1 levels were significantly increased in rats following maternal separation ( 85 ). In a mouse model of maternal separation, acute mixing stress induced lower blood pressure and heart rate responses ( 87 ). Maternal separation in rats resulted in misprogramming of resistance artery smooth muscle, increased vasoconstriction and blood pressure ( 88 ), and blood–brain barrier dysfunction ( 84 , 95 ).…”

Section: Impact Of Ela On the Cardiovascular System In Rodentsmentioning

confidence: 99%

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

Tan,

Zhou,

Chen

et al. 2024

Front. Public Health

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Strong epidemiological evidence has shown that early life adversity (ELA) has a profound negative impact on health in adulthood, including an increased risk of cardiovascular disease, the leading cause of death worldwide. Here, we review cohort studies on the effects of ELA on cardiovascular outcomes and the possible underlying mechanisms. In addition, we summarize relevant studies in rodent models of ELA. This review reveals that the prevalence of ELA varies between regions, time periods, and sexes. ELA increases cardiovascular health risk behaviors, susceptibility to mental illnesses, and neuroendocrine and immune system dysfunction in humans. Rodent models of ELA have been developed and show similar cardiovascular outcomes to those in humans but cannot fully replicate all ELA subtypes. Therefore, combining cohort and rodent studies to further investigate the mechanisms underlying the association between ELA and cardiovascular diseases may be a feasible future research strategy.

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Cardiovascular effects of Boophone disticha aqueous ethanolic extract on early maternally separated BALB/C mice

Cited by 11 publications

References 35 publications

Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents

Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents

Amaryllidaceae and Sceletium alkaloids

Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review

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