Cardiovascular Effects of Cannabinoids

Wang, Andy; Dey, Subo; Subhan, Sarah; Patel, Jay; Frishman, William H.; Aronow, Wilbert S.

doi:10.1097/crd.0000000000000566

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Cannabis impacts cardiovascular function primarily through autonomic nervous system modulation. Acute cannabis use induces sympathetic stimulation, elevating heart rate, blood pressure, and vascular resistance via cannabinoid receptor activation [40,41]. This stimulation triggers catecholamine release, including adrenaline and noradrenaline, affecting cardiac conduction pathways.…”

Section: A Sympathetic Stimulation and Autonomic Dysfunctionmentioning

confidence: 99%

“…THC, the main psychoactive compound in cannabis, has been linked to cardiovascular effects such as arrhythmias, acute coronary syndrome, and sudden cardiac death [41]. Cannabis and synthetic cannabinoids have been associated with adverse cardiovascular events like myocardial infarction, cardiomyopathy, arrhythmias, stroke, and cardiac arrest, potentially due to their impact on thrombosis, inflammation, and atherosclerosis [40].…”

Section: B Myocardial Ischemia and Coronary Artery Vasospasmmentioning

confidence: 99%

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Cannabinoids and Cardiac Rhythms: Unveiling the Relationship between Cannabis Use, ECG Changes, and Arrhythmias

Fahimi,

Beikmohammadi,

Rostami

2024

Preprint

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Understanding how cannabis affects our heart is like navigating through a maze of conflicting findings. While it's known for its diverse uses, from medicinal to industrial, cannabis also raises red flags regarding its impact on heart health. This review dives into the intricate relationship between cannabis use and cardiovascular well-being, particularly focusing on changes seen in electrocardiogram (ECG) readings, which serve as vital indicators of heart function and rhythm. When someone tokes up, their heart might race temporarily, but chronic cannabis use paints a darker picture, with potential risks of heart attacks and strokes looming on the horizon. The ECG alterations observed in cannabis users, such as irregular heartbeats and unusual wave patterns, hint at disruptions in the heart's normal workings. Furthermore, cannabis has been linked to prolonging the QT interval in the heart's electrical cycle, potentially setting the stage for dangerous arrhythmias. Amidst this mixed bag of effects, some studies even suggest that tiny amounts of THC, the main psychoactive component of cannabis, might lend a helping hand to the heart. However, caution flags are raised, especially for vulnerable groups. While researchers strive to unravel the mysteries of cannabis and the heart, limitations in current studies remind us that we're still far from having all the answers. Moving forward, future investigations should delve deeper into understanding how cannabis tinkers with our heart's inner workings, especially across different demographics. Armed with this knowledge, we can better tailor interventions to safeguard the heart health of cannabis users.

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Section: A Sympathetic Stimulation and Autonomic Dysfunctionmentioning

confidence: 99%

Section: B Myocardial Ischemia and Coronary Artery Vasospasmmentioning

confidence: 99%

Cannabinoids and Cardiac Rhythms: Unveiling the Relationship between Cannabis Use, ECG Changes, and Arrhythmias

Fahimi,

Beikmohammadi,

Rostami

2024

Preprint

View full text Add to dashboard Cite

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Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits

Hoch,

Volkow,

Friemel

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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The legalization of cannabis for medical and recreational purposes has progressed internationally. Cannabis and cannabinoids are advocated for a plethora of medical indications. An increasing number of medical and nonmedical users regularly consume large doses of delta-9-Tetrahydrocannabinol (THC), the main active component of cannabis. Aim: to summarize the evidence on (1) risks of recreational cannabis use and (2) effectiveness and safety of medicinal cannabis. Findings on recreational use: Cannabis is mostly used to experience its acute rewarding effects. Regular use of high THC products can produce addiction (cannabis use disorder or CUD). Acute consumption of high THC doses (including unintentionally) can cause time-limited mental, gastrointestinal, and cardiovascular problems and motor vehicle accidents. Chronic patterns of cannabis use have been associated with multiple adverse outcomes that are of particular concern among adolescents and young adults, such as, disrupted learning, impaired cognitive performance, reduced educational attainment and an increased risk of CUD, psychosis/schizophrenia, mood and anxiety disorders and suicidal behaviors. There is debate about the extent to which cannabis use is a cause of these adverse outcomes. Physical health risks (e.g., respiratory and cardiovascular, prematurity and restricted fetal growth, hyperemesis syndrome among others) have also been linked with repeated consumption of cannabis with a high THC content. Findings on medical cannabis use: Herbal cannabis, medicines from extracted or synthetized cannabinoids—often used as adjuvants to standard medicines—may produce small to modest benefits. This is primarily the case in treating chronic pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and refractory epilepsy (in the case of cannabidiol, CBD). The evidence is inconclusive on their value in treating mental disorders and other medical conditions. Safety: Cannabis-based medicine is generally well tolerated. There is a risk of mild to moderate adverse effects and CUD.

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Cardiovascular Effects of Cannabinoids

Cited by 2 publications

References 27 publications

Cannabinoids and Cardiac Rhythms: Unveiling the Relationship between Cannabis Use, ECG Changes, and Arrhythmias

Cannabinoids and Cardiac Rhythms: Unveiling the Relationship between Cannabis Use, ECG Changes, and Arrhythmias

Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits

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