Cardiovascular effects of cocaine during operant cocaine self-administration

Ambrosio, Emilio; Tella, Srihari R.; Goldberg, Steven R.; Schindler, Charles W.; Erzouki, Hashim K.; Elmer, Gregory I.

doi:10.1016/s0014-2999(96)00574-2

Cited by 15 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cocaine‐reinforced behavior was studied according to a procedure described previously 28. Briefly stated, before surgical implantation of the i.v.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Neuroadaptive Changes in NMDAR1 Gene Expression after Extinction of Cocaine Self‐Administration

Crespo

Martínez

Ghasemzadeh

et al. 2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The aim of the present work was to study the time course effects in levels of mRNA encoding N‐methyl‐d‐aspartate receptor subunit 1 (NMDAR1) after long‐term cocaine self‐administration (1 mg/kg/ injection) and its extinction using a yoked‐box procedure. NMDAR1 content was measured by quantitative in situ hybridization histochemistry in prefrontal cortex, caudate‐putamen, nucleus accumbens, olfactory tubercle, and piriform cortex immediately after cessation of the last session of cocaine self‐administration (Day 0) and 1, 5, and 10 days after the extinction period. The results show that long‐term cocaine self‐administration and its extinction alter NMDAR1 gene expression in these forebrain regions, and that the changes depend upon the brain region examined and the type of cocaine administration (contingent, noncontingent, and saline). Compared to saline and noncontingent cocaine administration, contingent cocaine produced an up‐regulation in NMDAR1 gene expression on Day 0 in all the brain regions analyzed. NMDAR1 levels of contingent animals decreased progressively in the absence of cocaine, and the decrement persisted 10 days after the extinction of cocaine self‐administration behavior in all the forebrain areas, with the exception of olfactory tubercle. In contrast, noncontingent cocaine administration did not produce any change in NMDAR1 gene expression on Day 0, and extinction resulted in an increase of NMDAR1 mRNA content on Days 1 and 5 and returned to control (saline) values on Day 10. These results suggest that an interaction between environmental stimuli and the pharmacological action of cocaine during drug self‐administration and its extinction may represent an important factor in the regulation of cocaine effects on NMDAR1 gene expression.

show abstract

“…Cocaine‐reinforced behavior was studied according to a procedure described previously 28. Briefly stated, before surgical implantation of the i.v.…”

Section: Methodsmentioning

confidence: 99%

“…Cocaine-reinforced behavior was studied according to a procedure described previously. 28 Briefly stated, before surgical implantation of the i.v. catheter, animals were trained to lever-press for food reinforcement under a fixed ratio-five (FR5) schedule of reinforcement.…”

Section: Methodsmentioning

confidence: 99%

Neuroadaptive Changes in NMDAR1 Gene Expression after Extinction of Cocaine Self‐Administration

Crespo

Martínez

Ghasemzadeh

et al. 2002

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…Acute COC administration has been shown to increase blood pressure and heart rate (Ambrosio et al, 1996), and functional alterations in brainstem noradrenergic nuclei responsible for autonomic function has been noted (Beveridge et al, 2004). COC-induced vasoconstriction can ultimately lead to stroke, hemorrhages, blood clots, and/or cerebral ischemia in abusers (Büttner et al, 2003;Peterson et al, 1991), including populations considered young for vascular impairments (Levine et al, 1991).…”

Section: Psychostimulant Neurotoxicitymentioning

confidence: 99%

Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: Current status of dopamine system vulnerability in NeuroAIDS

Ferris

Mactutus

Booze

2008

Neuroscience & Biobehavioral Reviews

119

131

View full text Add to dashboard Cite

There are roughly 30 to 40 million HIV infected individuals in the world as of December 2007, and drug abuse directly contributes to one-third of all HIV-infections in the United States. Antiretroviral therapy has increased the lifespan of HIV-seropositives, but CNS function often remains diminished, effectively decreasing quality of life. A modest proportion may develop HIV-associated dementia, the severity and progression of which is increased with drug abuse. HIV and drugs of abuse in the CNS target subcortical brain structures and DA systems in particular. This toxicity is mediated by a number of neurotoxic mechanisms, including but not limited to, aberrant immune response and oxidative stress. Therefore, novel therapeutic strategies must be developed that can address a wide variety of disparate neurotoxic mechanisms and apoptotic cascades. This paper reviews the research pertaining to the where, what, and how of HIV and cocaine/methamphetamine toxicity in the CNS. Specifically, where these toxins most affect the brain, what aspects of the virus are neurotoxic, and how these toxins mediate neurotoxicity.

show abstract

“…This effect persisted for up to 1 week following the end of self-administration and most likely reflects tolerance to the cardiovascular effects of acute methamphetamine exposure that developed during the prolonged self-administration period. Tolerance to the cardiovascular effects of self-administered cocaine is also observed in the absence of anesthesia (Ambrosio et al, 1996, Tella et al, 1999) and this tolerance is likely reflected under anesthetic conditions as seen here.…”

Section: Discussionmentioning

confidence: 50%

Delayed emergence of methamphetamine’s enhanced cardiovascular effects in nonhuman primates during protracted methamphetamine abstinence

Vaupel

Schindler

Chefer

et al. 2016

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background Methamphetamine abuse is linked with brain abnormalities, but its peripheral effects constitute an integral aspect of long-term methamphetamine use. Methods Eight male rhesus monkeys with long histories of intravenous methamphetamine self-administration were evaluated 1 day, and 1, 4, 12, 26, and 52 weeks after their last methamphetamine self-administration session. On test days, isoflurane-anesthetized animals received a 0.35 mg/kg IV methamphetamine challenge. A control group consisted of 10 age and gender matched drug naïve monkeys. Cardiovascular responses to methamphetamine were followed for 2.5 h. Echocardiograms were acquired at 3 and 12 months of abstinence and in the control animals. Results No pre-methamphetamine baseline differences existed among 7 physiological measures across all conditions and controls. As expected, methamphetamine increased heart rate and blood pressure in controls. However, immediately following the self-administration period, the blood pressure response to methamphetamine challenge was reduced when compared to control monkeys. The peak and 150-min average heart rate increases, as well as peak blood pressure increases following methamphetamine were significantly elevated between weeks 12 to 26 of abstinence. These data indicate the development of tolerance followed by sensitization to methamphetamine cardiovascular effects. Echocardiography demonstrated decreased left ventricular ejection fraction and cardiac output at 3 months of abstinence. Importantly, both cardiovascular sensitization and cardiotoxicity appeared to be reversible as they returned toward control group levels after 1 year of abstinence. Conclusions Enhanced cardiovascular effects may occur after prolonged abstinence in addicts relapsing to methamphetamine and may underlie clinically reported acute cardiotoxic events.

show abstract

Cardiovascular effects of cocaine during operant cocaine self-administration

Cited by 15 publications

References 21 publications

Neuroadaptive Changes in NMDAR1 Gene Expression after Extinction of Cocaine Self‐Administration

Neuroadaptive Changes in NMDAR1 Gene Expression after Extinction of Cocaine Self‐Administration

Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: Current status of dopamine system vulnerability in NeuroAIDS

Delayed emergence of methamphetamine’s enhanced cardiovascular effects in nonhuman primates during protracted methamphetamine abstinence

Contact Info

Product

Resources

About