Nasotracheal intubation is a skill greatly appreciated by anaesthetists and surgeons in head and neck specialities. The introduction of fibreoptic intubation has revolutionized the anaesthetic management of difficult airway and its increasing use in clinical anaesthesia has drawn attention to the circulatory responses during fibreoptic intubation. The aim of this study was to compare changes in Heart rate, Systolic and Diastolic blood pressures, SpO2 and EtCO2 levels, associated complications and time required to achieve successful nasotracheal intubation with fibreoptic and laryngoscopic technique. 100 patients of ASA grade I & II between 18-50 yrs of age undergoing elective surgeries requiring nasotracheal intubation were allocated into two groups. Group I was intubated in the conventional manner using a Macintosh laryngoscope and Group II was intubated using a fibreoptic bronchoscope. Vital parameters like heart rate, blood pressure (Systolic and diastolic), ECG, oxygen saturation, EtCO2 and N2O/Isoflurane% with O2 were continuously monitored and recorded preoperatively, immediately after induction, at intubation and every 1min for further 5 min. Intubation time was also recorded. Incidence of epistaxis and post-operative sore throat were noted. Nasotracheal intubation was accompanied by significant increases in blood pressure and heart rate compared to post induction values in both groups but there was no significant difference between the two groups. SpO2 and EtCO2 were maintained within normal range during both of intubation procedures, although the time required for intubation was longer in fibreoptic bronchoscope group. There was no significant difference in the incidence of epistaxis between the two groups. It was concluded that stress response to fibreoptic nasotracheal intubation in similar to nasotracheal intubation facilitated by Macintosh laryngoscope.