Cardiovascular Effects of I.V. Induction in Children: Comparison Between Propofol and Thiopentone

Abstract

We have compared the haemodynamic responses to i.v. propofol 2.5 mg kg-1 with those to thiopentone 5.0 mg kg-1 in 41 healthy Chinese children at induction of anaesthesia. They were allocated to four groups according to their age and induction agent received: group 1 < 2 yr, propofol, n = 9; group II < 2 yr, thiopentone, n = 9; group III 2-12 yr, propofol, n = 12; group IV 2-12 yr, thiopentone, n = 11. Anaesthesia was maintained by spontaneous ventilation with 70% nitrous oxide and 0.5% halothane in oxygen. Arterial pressure and heart rate were monitored by automatic oscillotonometer. Stroke volume was measured by two-dimensional echocardiography and pulse Doppler. Measurements were made before induction and at 1-min intervals for 5 min after induction. The reduction in mean arterial pressure was significantly greater after propofol (28-31%) than after thiopentone (14-21%) (P = 0.001). The reduction in cardiac index (10-15%) after induction was not significantly different between the two agents (P = 0.122). Baroreflex mediated increases in heart rate and systemic vascular resistance were less after propofol than after thiopentone. The baroreceptor reflex was more attenuated in children aged less than 2 yr than in older children.

Effects of thiopental sodium, ketamine, and propofol on the onset time of rocuronium in children

“…However, the reduction in cardiac index is not significantly different between propofol and thiopental sodium groups [16]. In the current study, reduction of MAP was greater after the administration of propofol compared to that after the administration of thiopental sodium, although the different was not statistically significant.…”

“…When cardiovascular effects are compared between propofol and thiopental sodium, MAP has been found to be decreased greater after the administration of propofol than that after the administration of thiopental sodium [16]. However, the reduction in cardiac index is not significantly different between propofol and thiopental sodium groups [16].…”

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

“…However, it has drawbacks, such as a greater risk of cardiovascular effects, besides prolonged blockade 11,27,28 . Although one of the adverse effects of propofol is reduced cardiac index and systemic vascular resistance with consequent hypotension 29 , there were no signifi cant changes in the hemodynamic parameters of both groups in the present study that could have infl uenced the neuromuscular block.…”

Haemodynamic changes after induction of anaesthesia with sevoflurane vs. propofol

“…(22) Propofol is believed to cause a reduction in systolic and diastolic arterial pressures by lowering SVRI and afterload. (23) Some studies on people and animals showed that it had no influence on CI, (23)(24)(25) while in others it caused a reduction in CI. (26,27) Its haemodynamic effects depend on the speed of administration and on associated cardiovascular diseases.…”