Cardiovascular Effects of Isosorbide Dinitrate Infused Intravenously Into Anaesthetized Dogs

Kuromaru, Osamu; Sakai, Kazushige

doi:10.1111/j.1440-1681.1986.tb00947.x

Cited by 8 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that ISDN administration results in reduced systemic venous pressure, leading to a reduction of the myocardial work load and oxygen consumption [2,4,5,8,11]. ISDN is therefore a useful agent in the treatment of angina pectoris and congestive heart failure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Sustained Release Isosorbide Dinitrate (EV151) in Dogs with Experimentally-Induced Mitral Insufficiency

Nagasawa¹,

Takashima²,

Masuda³

et al. 2003

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. To investigate the hemodynamic effects on seven anesthetized dogs with experimentally-induced mitral insufficiency, isosorbide dinitrate (ISDN) in sustained release form (EV151) was administered at different dosages (0, 2, 8 and 16 mg/kg). The drug administration resulted in altered pulmonary arterial wedge pressure (preload), and cardiac output and total systemic resistance (afterload). Arterial pressure increased in the control group and in animals receiving 2 mg/kg, but decreased in animals 1-2 hr after receivi ng 8 and 16 mg/kg dosages. Cardiac output increased in animals receiving 2, 8 and 16 mg/kg dosages, with concomitant decreases in total systemic resistance. ISDN caused mild vasodilation at 2 mg/kg and severe vasodilation at 8 and 16 mg/kg. Future experiments on nonanesthetized dogs may be of benefit. KEY WORDS: canine, isosorbide dinitrate, mitral insufficiency.

show abstract

Section: Discussionmentioning

confidence: 99%

“…ISDN acts by lowering systemic venous pressure, leading to a reduction of the myocardial work-load and oxygen consumption [2,4,5,8,11].…”

mentioning

confidence: 99%

Effect of Sustained Release Isosorbide Dinitrate (EV151) in Dogs with Experimentally-Induced Mitral Insufficiency

Nagasawa¹,

Takashima²,

Masuda³

et al. 2003

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…This evidence may be important for the application of the drug in heart failure. Comparative changes in cardiovascular parameters, by the sustained IV route, were observed with nicorandil in anesthetized dogs [28][29][30].…”

Section: Cardiovascular Actionmentioning

confidence: 99%

“…Furthermore, the development of tolerance to nicorandil was examined in thoracotomized dogs [28][29][30]. The vasodilator effect of nicorandil administered locally into the coronary artery was not significantly affected by IV infusion of either nicorandil (10 ~g/kg/ rain), isosorbide dinitrate (10 or 30 ~g/kg/min), or nitroglycerin (1 or 3 ~g/kg/min).…”

Section: Tolerancementioning

confidence: 99%

Pharmacology and therapeutic effects of nicorandil

Kinoshita

Sakai²

1990

Cardiovasc Drug Ther

Self Cite

View full text Add to dashboard Cite

Nicorandil, a nicotinamide derivative, is an orally efficacious antianginal drug possessing a nitrate moiety in its chemical structure. This drug is an effective and well-tolerated treatment for various types of angina pectoris. Its general efficacy is similar to that of nitrates, with several unique effects on the cardiovascular system. Nicorandil causes sustained dilation of both the arterial resistance and conductive vessels, thus markedly dilating the coronary artery and increasing coronary blood flow. In addition, nicorandil, unlike nitroglycerin or isosorbide dinitrate, possesses little hemodynamic effect on heart rate, blood pressure, or cardiac contractility with clinical doses yielding antianginal effects. The mechanism causing coronary vasodilation has not been completely clarified but appears to be associated partly with increases in c-GMP, as well as the hyperpolarization of the smooth muscle membrane. Nicorandil, in single oral doses of 10-30 mg, has been shown to be effective in chronic stable angina, as assessed objectively by increases in exercise duration and/or the time to onset of ST-segment depression during treadmill exercise. In open studies and controlled efficacy evaluations, nicorandil in daily oral doses of 15-40 mg demonstrated significant effectiveness in the treatment of various types of angina pectoris. Headaches due to vasodilation may occur, and some side effects occurred in 5.1-34% of patients receiving nicorandil, but were generally minor in nature. There was no depressant effect on atrioventricular conduction, which occurs frequently in patients treated with calcium antagonists of the verapamil and diltiazem type. Nicorandil may be effective even in patients with rest and effort angina who do not respond to combination therapy with calcium antagonists and oral nitrates. Thus, nicorandil appears to be a valuable addition to the arsenal of antianginal drugs due to its low incidence of serious side effects.

show abstract

“…Isosorbide dinitrate (ISDN) causes venous vasodilation, and leads to a reduction in preload and cardiac oxygen consumption . Furthermore, ISDN causes a decrease in arterial pressure and reduction in afterload .…”

mentioning

confidence: 99%

Effects of a Sustained‐Release Form of Isosorbide Dinitrate on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation

Yamamoto

Suzuki

Hamabe

et al. 2013

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: The effects of isosorbide dinitrate (ISDN) have not been sufficiently investigated in conscious dogs with mitral valve regurgitation (MR).Objective: The objective was to investigate the effects of a sustained-release form of ISDN (sr-ISDN) on hemodynamics and the autonomic nervous system in dogs with MR.Animals: Six healthy Beagles weighing 11.2 AE 2.2 kg (2 years of age; 2 males and 4 females) were used. Methods: Experimental, crossover, and interventional study. Dogs with experimentally induced MR were administered placebo, 2, 5, and 10 mg/kg sr-ISDN PO on separate days with a 7-day washout period between randomized dosings. Left atrial pressure (LAP) had been recorded continuously from 30 minutes before administration of sr-ISDN to 12 hours after administration.Results: LAP was significantly decreased after administration in the 5 and 10 mg/kg groups. Significant decrease was observed at 3 and 4 hours after administration in the 5 mg/kg group. In the 10 mg/kg group, significant decrease was observed at 2, 3, 4, 5, 6, 7, 10, and 11 hours after administration. The lowest value was observed at 4 hours after administration in the 5 and 10 mg/kg groups (20.9 AE 4.2 to 15.9 AE 3.9 mmHg, P < .01, and 21.3 AE 4.0 to 13.6 AE 4.2 mmHg, P < .001).Conclusions and Clinical Importance: Sustained-release form of ISDN showed significant decrease of LAP in the 5 mg/kg and 10 mg/kg groups, and duration of effect was dose related.

show abstract

Cardiovascular Effects of Isosorbide Dinitrate Infused Intravenously Into Anaesthetized Dogs

Cited by 8 publications

References 16 publications

Effect of Sustained Release Isosorbide Dinitrate (EV151) in Dogs with Experimentally-Induced Mitral Insufficiency

Effect of Sustained Release Isosorbide Dinitrate (EV151) in Dogs with Experimentally-Induced Mitral Insufficiency

Pharmacology and therapeutic effects of nicorandil

Effects of a Sustained‐Release Form of Isosorbide Dinitrate on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation

Contact Info

Product

Resources

About