1978
DOI: 10.1097/00132586-197808000-00029
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Cardiovascular Effects of Meperidine-N20 Anesthesia Before and After Pancuronium

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Cited by 3 publications
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“…The hemodynamic effects of meperidine treatment for postoperative pain control have been studied well. [7][8][9][10] Those studies indicate that meperidine decreases vascular tone and may cause a slight decrease in blood pressure with a 2 to 2.5 mg/kg intravenous bolus. In our study the dose used for postoperative patient-controlled analgesia was one-twentieth of the above-mentioned dose in an hour.…”
Section: Discussionmentioning
confidence: 99%
“…The hemodynamic effects of meperidine treatment for postoperative pain control have been studied well. [7][8][9][10] Those studies indicate that meperidine decreases vascular tone and may cause a slight decrease in blood pressure with a 2 to 2.5 mg/kg intravenous bolus. In our study the dose used for postoperative patient-controlled analgesia was one-twentieth of the above-mentioned dose in an hour.…”
Section: Discussionmentioning
confidence: 99%
“…The concomitant sympathetic stimulation brings about an increase in systemic vascular resistance before but not after cardiopulmonary bypass during the morphine-based anaesthesia (8, 1 1, 28). Meperidine-N*O anaesthesia produces a severe increase of systemic vascular resistance together with a marked decrease in cardiac output and mean arterial pressure, the changes being attenuated if pancuronium is used for muscular paralysis (29). On the other hand, McCammon et al found no significant haemodynamic effects during N20-application in diazepam-anaesthesia (30), and they concluded that the harmful effects of N 2 0 detected during morphine-based anaesthesia were exaggerated by the morphine itself.…”
Section: Discussionmentioning
confidence: 99%
“…Later on, however, in animal studies cardiovascular depressant effects of meperidine were noted (8-1 l ) , and even potentiated on addition ofN,O (1 1). In man, N,O-meperidine anesthesia was shown to reduce blood pressure moderately but to depress cardiac output markedly ( 12).…”
mentioning
confidence: 99%