Cardiovascular effects of radiation therapy

Armanious, Merna; Mohammadi, Homan; Khodor, Sara; Oliver, Daniel; Johnstone, Peter A.S.; Fradley, Michael G.

doi:10.1016/j.currproblcancer.2018.05.008

Cited by 50 publications

(26 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the use of radiotherapy is becoming increasingly frequent, and since the overall patient survival rate is high, the risks associated with radiotherapy must be carefully considered. Among these risks, cardiovascular diseases (CVDs) have always attracted much attention, since CVD is the leading cause of nonmalignant tumor-related deaths in cancer survivors [1].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Radiation-Induced Cardiotoxicity

Zhang

Yang

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

122

View full text Add to dashboard Cite

There is a distinct increase in the risk of heart disease in people exposed to ionizing radiation (IR). Radiation-induced heart disease (RIHD) is one of the adverse side effects when people are exposed to ionizing radiation. IR may come from various forms, such as diagnostic imaging, radiotherapy for cancer treatment, nuclear disasters, and accidents. However, RIHD was mainly observed after radiotherapy for chest malignant tumors, especially left breast cancer. Radiation therapy (RT) has become one of the main ways to treat all kinds of cancer, which is used to reduce the recurrence of cancer and improve the survival rate of patients. The potential cause of radiation-induced cardiotoxicity is unclear, but it may be relevant to oxidative stress. Oxidative stress, an accumulation of reactive oxygen species (ROS), disrupts intracellular homeostasis through chemical modification and damages proteins, lipids, and DNA; therefore, it results in a series of related pathophysiological changes. The purpose of this review was to summarise the studies of oxidative stress in radiotherapy-induced cardiotoxicity and provide prevention and treatment methods to reduce cardiac damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Radiation-Induced Cardiotoxicity

Zhang

Yang

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

122

View full text Add to dashboard Cite

show abstract

“…Meticulous follow up is important taking into account the late manifestation of some cardiovascular side effects manifesting after long periods after RT. Among the adverse effects of pulmonary irradiation, radiation induced cardiotoxicity deserves utmost concern as addressed by several authors [54][55][56][57][58][59][60][61][62][63][64][65][66]. These studies consistently underscored the importance of minimizing cardiac exposure as much as possible to avoid untowards morbidity and mortality.…”

Section: Irradiation Sequelae On the Cardiovascular System In Pulmonamentioning

confidence: 99%

A concise review of irradiation sequelae on the cardiovascular system in pulmonary malignancies

Sager¹,

Beyzadeoğlu²,

Dincoglan³

et al. 2020

J Surg Surgical Res

View full text Add to dashboard Cite

“…Many IR-associated normal tissue damages are acute toxicities, characterizing potentially reversible and self-limited; however, some types of damages develop late sequelae, which are highly irreversible and progressively worse (4)(5)(6). For example, though the incidence is rare, irradiated cancer patients who had IR dose sprinkling to the cardiovascular system may encounter radiation-associated cardiovascular dysfunctions (RACVDs) (7)(8)(9), including blood pressure reduction (10), carotid stenosis (11), pericardial disease (12), myocardial infarction (13), pericardial/myocardial fibrosis (14,15), valvular heart disease (16), arrhythmia (17), and subsequent heart failure (18)(19)(20). On clinical presentation, many RACVDs are late RT sequelae, developing a few years later after RT (21).…”

Section: Introductionmentioning

confidence: 99%

Emerging Challenges of Radiation-Associated Cardiovascular Dysfunction (RACVD) in Modern Radiation Oncology: Clinical Practice, Bench Investigation, and Multidisciplinary Care

Lee

Liu

Hung

et al. 2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Radiotherapy (RT) is a crucial treatment modality in managing cancer patients. However, irradiation dose sprinkling to tumor-adjacent normal tissues is unavoidable, generating treatment toxicities, such as radiation-associated cardiovascular dysfunction (RACVD), particularly for those patients with combined therapies or pre-existing adverse features/comorbidities. Radiation oncologists implement several efforts to decrease heart dose for reducing the risk of RACVD. Even applying the deep-inspiration breath-hold (DIBH) technique, the risk of RACVD is though reduced but still substantial. Besides, available clinical methods are limited for early detecting and managing RACVD. The present study reviewed emerging challenges of RACVD in modern radiation oncology, in terms of clinical practice, bench investigation, and multidisciplinary care. Several molecules are potential for serving as biomarkers and therapeutic targets. Of these, miRNAs, endogenous small non-coding RNAs that function in regulating gene expression, are of particular interest because low-dose irradiation, i.e., 200 mGy (one-tenth of conventional RT daily dose) induces early changes of pro-RACVD miRNA expression. Moreover, several miRNAs, e.g., miR-15b and miR21, involve in the development of RACVD, further demonstrating the potential bio-application in RACVD. Remarkably, many RACVDs are late RT sequelae, characterizing highly irreversible and progressively worse. Thus, multidisciplinary care from oncologists and cardiologists is crucial. Combined managements with commodities control (such as hypertension, hypercholesterolemia, and diabetes), smoking cessation, and close monitoring are recommended. Some agents show abilities for preventing and managing RACVD, such as statins and angiotensin-converting enzyme inhibitors (ACEIs); however, their real roles should be confirmed by further prospective trials.

show abstract

Cardiovascular effects of radiation therapy

Cited by 50 publications

References 69 publications

Oxidative Stress in Radiation-Induced Cardiotoxicity

Oxidative Stress in Radiation-Induced Cardiotoxicity

A concise review of irradiation sequelae on the cardiovascular system in pulmonary malignancies

Emerging Challenges of Radiation-Associated Cardiovascular Dysfunction (RACVD) in Modern Radiation Oncology: Clinical Practice, Bench Investigation, and Multidisciplinary Care

Contact Info

Product

Resources

About