Cardiovascular effects of secretin infusion in man

Gunnes, P.; Waldum, H. L.; Rasmussen, K.; Østensen, H.; Burhol, P. G.

doi:10.3109/00365518309168843

Cited by 26 publications

(31 citation statements)

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“…However, the increase in cardiac output is not only observed after carbohydrate meals but also after ingestion of fat and protein where not much insulin is expected to be released. Secretin increases heart rate and cardiac output during digestion in dogs and humans (12,13), and the intestinal hormone oxyntomodulin, which is released during digestion, increases intrinsic heart rate in mice when administered peripherally (40). It is tempting to speculate, that as the ingested food is being processed and moves along in the gastrointestinal system, this progressively stimulates the release of various hormones and regulatory peptides, which then directly or indirectly induce the responses to digestion including the postprandial increase in cardiac output and heart rate.…”

Section: Role Of Histamine During Digestion In Pythonsmentioning

confidence: 99%

“…Little is known, however, about the regulation of this response. In addition to the autonomic nervous systems (8,15), the postprandial cardiovascular response is probably governed by the direct action of hormones such as endocrine regulatory peptides released from the gastrointestinal organs (3,7,12). In fact, patients with transplanted and fully denervated hearts exhibit a pronounced postprandial rise in cardiac output (19,44,45), suggesting that the cardiac stimulation is not reflex in nature, but, at least partially, mediated by humoral factor(s).…”

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confidence: 97%

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Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons

Skovgaard¹,

Møller²,

Gesser³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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The intrinsic heart rate of most vertebrates studied, including humans, is elevated during digestion, suggesting that a nonadrenergic-noncholinergic factor contributes to the postprandial tachycardia. The regulating factor, however, remains elusive and difficult to identify. Pythons can ingest very large meals, and digestion is associated with a marked rise in metabolism that is sustained for several days. The metabolic rise causes more than a doubling of heart rate and a fourfold rise in cardiac output. This makes the python an interesting model to investigate the postprandial tachycardia. We measured blood pressure and heart rate in fasting Python regius, and at 24 and 48 h after ingestion of a meal amounting to 25% of body wt. Digestion caused heart rate to increase from 25 to 56 min, whereas blood pressure was unchanged. The postprandial rise in heart rate was partially due to a doubling of intrinsic heart rate. The H(2)-antagonist did not affect heart rate of fasting snakes but decreased heart rate by 15-20 min at 24 h into digestion, whereas it had no effects at 48 h. Thus, the histaminergic tone on the heart rose from none to 30% at 24 h but vanished after 48 h. In anesthetized snakes, histamine caused a systemic vasodilatation and a marked increase in heart rate and cardiac output mediated through a direct effect on H(2)- receptors. Our study strongly indicates that histamine regulates heart rate during the initial phase of digestion in pythons. This study describes a novel regulation of the vertebrate heart.

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Section: Role Of Histamine During Digestion In Pythonsmentioning

confidence: 99%

mentioning

confidence: 97%

Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons

Skovgaard¹,

Møller²,

Gesser³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Furthermore, it could activate adenylate cyclase in the heart in the presence of guanosine 5′‐triphosphate (GTP), 35 even though its efficacy varies from species to species; it is active only in the rat but not in the guinea pig, rabbit, dog, and monkey 36 . Finally, secretin was also demonstrated to ( a ) increase stroke volume while decreasing the total systemic resistance in humans, 37 ( b ) stimulate the contractility rate of spontaneously beating right atrium in rats, 38 ( c ) potentiate the Ba 2+ currents in isolated adult rat ventricular myocytes, 39 and ( d ) modify the effect of L‐NAME on coronary permeability in both intact and diabetic rats 40 …”

Section: Introductionmentioning

confidence: 99%

Secretin: A Pleiotrophic Hormone

Chu

Yung

Chow

2006

Annals of the New York Academy of Sciences

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Secretin holds a unique place in the history of endocrinology and gastrointestinal physiology, as it is the first peptide designated as a hormone. During the last century since its first discovery, the hormonal effects of secretin in the gastrointestinal tract were extensively studied, and its principal role in the periphery was found to stimulate exocrine secretion from the pancreas. Recently, a functional role of secretin in the brain has also been substantiated, with evidence suggesting a possible role of secretin in embryonic brain development. Given that secretin and its receptors are widely expressed in multiple tissues, this peptide should therefore exhibit pleiotrophic functions throughout the body. The present article reviews the current knowledge on the central and peripheral effects of secretin as well as its therapeutic uses.

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“…It is noticeable though that postprandial increases in CO is observed not only after carbohydrate meals but also after meals of fat and protein (Waaler and Eriksen 1992) where one would not expect much insulin to be released. It is further of considerable interest to note that the hormone secretin was shown some years ago to increase CO in dogs (Gunnes et al 1985) as well as in humans (Gunnes et al 1983). Secretin was shown to have both a chronotropic eVect and an ionotropic eVect.…”

Section: Discussionmentioning

confidence: 97%

Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts

et al. 2006

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Consumption of a meal is followed by an increase in cardiac output (CO) which appears to be closely related to the concomitant increase in blood flow to the gastrointestinal organs. To gain information on the mechanism behind this increase in CO we have previously used Doppler ultrasound technique to record circulatory responses to a standardized meal in five patients with recently transplanted and thus denervated hearts. We obtained the surprising result that they reacted to the consumption of a meal with a greater increase in CO than did five matched normal controls. The patients also presented above-normal levels of heart rate (HR) and CO at rest. The same five patients have now been tested 18 months later to re-examine their remarkable cardiac response to ingestion of a meal. The hearts of two patients showed some signs of reinnervation, whereas the hearts of the other three were apparently still fully denervated. However, all five patients once again evolved a marked cardiac response to ingestion of a meal. Postprandial CO reached significantly higher levels in the patients than in the controls. The persistence of such a pronounced postprandial augmentation of CO in transplanted and largely denervated hearts strengthens the assumption that the heart is induced to increase its postprandial performance through the action of a humoral agent of some sort, possibly one of the hormones from the duodenal-pancreatic region.

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Cardiovascular effects of secretin infusion in man

Cited by 26 publications

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Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons

Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons

Secretin: A Pleiotrophic Hormone

Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts

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Cardiovascular effects of secretin infusion in man

Cited by 26 publications

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Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythons

Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythons

Secretin: A Pleiotrophic Hormone

Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts

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Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons

Histamine induces postprandial tachycardia through a direct effect on cardiac H₂-receptors in pythons